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Since the beginning of 2020, the coronavirus disease 2019 (COVID-19) has spread rapidly in the city of Wuhan, P.R. China, and subsequently, across the world. The swift spread of the virus is largely attributed to its stealth transmissions…

Applications · Statistics 2020-04-06 Grace Yi , Wenqing He , Dennis Kon-Jin Lin , Chun-Ming Yu

Population-wide screening is a powerful tool for controlling infectious diseases. Group testing enables such screening despite limited resources. Viral concentration of pooled samples are often positively correlated, either because…

Applications · Statistics 2025-04-01 Jiayue Wan , Yujia Zhang , Peter I. Frazier

We analyze the effect of using a screening CT-scan for evaluation of potential COVID-19 infections in order to isolate and perform contact tracing based upon a viral pneumonia diagnosis. RT-PCR is then used for continued isolation based…

Populations and Evolution · Quantitative Biology 2020-06-04 Chen Shen , Ron Mark , Nolan J. Kagetsu , Anton S. Becker , Yaneer Bar-Yam

We have a large number of samples and we want to find the infected ones using as few number of tests as possible. We can use group testing which tells about a small group of people whether at least one of them is infected. Group testing is…

Quantitative Methods · Quantitative Biology 2020-05-07 Endre Csóka

In this paper, we propose algorithms that leverage a known community structure to make group testing more efficient. We consider a population organized in connected communities: each individual participates in one or more communities, and…

Information Theory · Computer Science 2021-03-18 Pavlos Nikolopoulos , Sundara Rajan Srinivasavaradhan , Tao Guo , Christina Fragouli , Suhas Diggavi

The development of fast and accurate screening tools, which could facilitate testing and prevent more costly clinical tests, is key to the current pandemic of COVID-19. In this context, some initial work shows promise in detecting…

Group testing allows saving chemical reagents, analysis time, and costs, by testing pools of samples instead of individual samples. We introduce a class of group testing protocols with small dilution, suited to operate even at high…

Physics and Society · Physics 2022-03-09 Marco Chiani , Gianluigi Liva , Enrico Paolini

Pooling specimens, a well-accepted sampling strategy in biomedical research, can be applied to reduce the cost of studying biomarkers. Even if the cost of a single assay is not a major restriction in evaluating biomarkers, pooling can be a…

Applications · Statistics 2012-03-01 Enrique F. Schisterman , Albert Vexler , Aijun Ye , Neil J. Perkins

COVID-19 is a virus with high transmission rate that demands rapid identification of the infected patients to reduce the spread of the disease. The current gold-standard test, Reverse-Transcription Polymerase Chain Reaction (RT-PCR), has a…

In epidemic or pandemic situations, resources for testing the infection status of individuals may be scarce. Although group testing can help to significantly increase testing capabilities, the (repeated) testing of entire populations can…

Populations and Evolution · Quantitative Biology 2021-10-29 Günther Koliander , Georg Pichler

The exponential increase in COVID-19 patients is overwhelming healthcare systems across the world. With limited testing kits, it is impossible for every patient with respiratory illness to be tested using conventional techniques (RT-PCR).…

Image and Video Processing · Electrical Eng. & Systems 2020-04-22 Arpan Mangal , Surya Kalia , Harish Rajgopal , Krithika Rangarajan , Vinay Namboodiri , Subhashis Banerjee , Chetan Arora

COVID-19 pandemic has reshaped our world in a timescale much shorter than what we can understand. Particularities of SARS-CoV-2, such as its persistence in surfaces and the lack of a curative treatment or vaccine against COVID-19, have…

The COVID-19 pandemic is one of the most challenging healthcare crises during the 21st century. As the virus continues to spread on a global scale, the majority of efforts have been on the development of vaccines and the mass immunization…

Machine Learning · Computer Science 2021-09-07 Meysam Effati , Yu-Chen Sun , Hani E. Naguib , Goldie Nejat

A deterministic model with testing of infected individuals has been proposed to investigate the potential consequences of the impact of testing strategy. The model exhibits global dynamics concerning the disease-free and a unique endemic…

Populations and Evolution · Quantitative Biology 2023-05-24 Sarita Bugalia , Jai Prakash Tripathi

We propose a monitoring strategy for efficient and robust estimation of disease prevalence and case numbers within closed and enumerated populations such as schools, workplaces, or retirement communities. The proposed design relies largely…

Methodology · Statistics 2024-04-22 Robert H. Lyles , Yuzi Zhang , Lin Ge , Lance A. Waller

Coronavirus Disease 2019 (COVID-19) has spread globally and become a health crisis faced by humanity since first reported. Radiology imaging technologies such as computer tomography (CT) and chest X-ray imaging (CXR) are effective tools for…

Image and Video Processing · Electrical Eng. & Systems 2022-07-05 Hongyan Xu , Dadong Wang , Arcot Sowmya

The rapid and seemingly endless expansion of COVID-19 can be traced back to the inefficiency and shortage of testing kits that offer accurate results in a timely manner. An emerging popular technique, which adopts improvements made in…

Image and Video Processing · Electrical Eng. & Systems 2021-05-21 Shehan Perera , Srikar Adhikari , Alper Yilmaz

Testing for infection with SARS-CoV-2 is an important intervention in reducing onwards transmission of COVID-19, particularly when combined with the isolation and contact-tracing of positive cases. Many countries with the capacity to do so…

Populations and Evolution · Quantitative Biology 2022-07-19 Miguel E. P. Silva , Martyn Fyles , Li Pi , Jasmina Panovska-Griffiths , Caroline Jay , Thomas House , Elizabeth Fearon

Group testing can help maintain a widespread testing program using fewer resources amid a pandemic. In group testing, we are given $n$ samples, one per individual. These samples are arranged into $m < n$ pooled samples, where each pool is…

Information Theory · Computer Science 2022-01-20 Ritesh Goenka , Shu-Jie Cao , Chau-Wai Wong , Ajit Rajwade , Dror Baron

Group testing is a screening strategy that involves dividing a population into several disjointed groups of subjects. In its simplest implementation, each group is tested with a single test in the first phase, while in the second phase only…

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