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Electron cryo-tomography (cryo-ET) enables 3D imaging of complex, radiation-sensitive structures with molecular detail. However, image contrast from the interference of scattered electrons is nonlinear with atomic density and multiple…

Transport of fast electron in overdense plasmas is of key importance in high energy density physics. However, it is challenging to diagnose the fast electron transport in experiments. In this article, we study coherent transition radiation…

Cryo-electron microscopy (cryo-EM) has become a major experimental technique to determine the structures of large protein complexes and molecular assemblies, as evidenced by the 2017 Nobel Prize. Although cryo-EM has been drastically…

Biomolecules · Quantitative Biology 2021-06-01 Dong Si , Andrew Nakamura , Runbang Tang , Haowen Guan , Jie Hou , Ammaar Firozi , Renzhi Cao , Kyle Hippe , Minglei Zhao

Inferior soft-tissue contrast resolution is a major limitation of current CT scanners. The aim of the study is to improve the contrast resolution of CT scanners using dual-energy acquisition. Based on dual-energy material decomposition, the…

Medical Physics · Physics 2016-11-15 Wei Zhao , Lu Wan , Bo Zhang , Qiude Zhang , Tianye Niu

We explore methods for robust estimation of the 21 cm signal from the Epoch of Reionisation (EoR). A Kernel Density Estimator (KDE) is introduced for measuring the spatial temperature fluctuation power spectrum from the EoR. The KDE…

Enhancing cryogenic electron microscopy (cryo-EM) 3D density maps at intermediate resolution (4-8 {\AA}) is crucial in protein structure determination. Recent advances in deep learning have led to the development of automated approaches for…

Computer Vision and Pattern Recognition · Computer Science 2025-05-16 Chenwei Zhang , Khanh Dao Duc

Ultrafast electron diffraction (UED) instruments typically operate at kHz or lower repetition rates and rely on indirect detection of electrons. However, these experiments encounter limitations because they are required to use electron…

Chemical Physics · Physics 2024-08-06 Fernando Rodriguez Diaz , Mark Mero , Kasra Amini

We propose a method to probe the local density of states (LDOS) of atomic systems that provides both spatial and energy resolution. The method combines atomic and tunneling techniques to supply a simple, yet quantitative and operational,…

Mesoscale and Nanoscale Physics · Physics 2018-11-22 Daniel Gruss , Chih-Chun Chien , Julio Barreiro , Massimiliano Di Ventra , Michael Zwolak

In future nuclear fusion reactors high heat load events, such as edge-localised modes (ELMs), can potentially damage divertor materials and release impurities into the main plasma, limiting plasma performance. The most difficult to handle…

Plasma Physics · Physics 2016-11-24 S. Elmore , S. Y. Allan , G. Fishpool , A. Kirk , A. J. Thornton , N. R. Walkden , J. R. Harrison

Cryogenic characterization of transition-edge sensor (TES) bolometers is a time- and labor-intensive process. As new experiments deploy larger and larger arrays of TES bolometers, the testing process will become more of a bottleneck. Thus…

Instrumentation and Methods for Astrophysics · Physics 2024-08-16 K. R. Ferguson , A. N. Bender , N. Whitehorn , T. W. Cecil

Transmission electron microscopy (TEM) is a potent technique for the determination of three-dimensional atomic scale structure of samples in structural biology and materials science. In structural biology, three-dimensional structures of…

Despite decades of research, the ultimate goal of nanotechnology--top-down manipulation of individual atoms--has been directly achieved with only one technique: scanning probe microscopy. In this Review, we demonstrate that scanning…

Nanoscale materials usually can trap light and strongly interact with it leading to many photonic device applications. The light-matter interactions are commonly probed by optical spectroscopy, which, however, have some limitations such as…

Mesoscale and Nanoscale Physics · Physics 2022-08-24 Jinlong Du , Jin-hui Chen , Yuehui Li , Ruochen Shi , Mei Wu , Yun-Feng Xiao , Peng Gao

Cryogenic calorimetric detectors are a powerful tool in the search for rare events such as neutrinoless double beta decay ($0\nu\beta \beta$), due to their excellent energy resolution and low intrinsic background. The performance of these…

Instrumentation and Detectors · Physics 2026-05-22 Enzo Brandani , Yael Zayats , Vladyslav Berest , Tong Zhu , Yury Kolomensky

Electron-photon temporal correlations in electron energy loss (EELS) and cathodoluminescence (CL) spectroscopies have recently been used to measure the relative quantum efficiency of materials. This combined spectroscopy, named…

Electronic devices are engineered at increasingly smaller length scales; new metrologies to understand nanoscale thermodynamics are needed. Temperature and pressure are fundamental thermodynamic quantities whose nanoscale measurement is…

Mesoscale and Nanoscale Physics · Physics 2025-10-24 Yueyun Chen , Xin Yi Ling , Jared Lodico , Tristan P. O`Neill , B. C. Regan , Matthew Mecklenburg

Predictive and real-time inference capability for the upstream separatrix electron density, $n_\text{e, sep}$, is essential for design and control of core-edge integrated plasma scenarios. In this study, both supervised and semi-supervised…

Plasma Physics · Physics 2023-01-18 A. Kit , A. Jaervinen , S. Wiesen , Y. Poels , L. Frassinetti

Purpose: Electron density is the most important tissue property influencing photon and ion dose distributions in radiotherapy patients. Dual-energy computed tomography (DECT) enables the determination of electron density by combining the…

Medical Physics · Physics 2017-06-29 Christian Möhler , Patrick Wohlfahrt , Christian Richter , Steffen Greilich

Diamond operated as a cryogenic calorimeter is an excellent target for direct detection of low-mass dark matter candidates. Following the realization of the first low-threshold cryogenic detector that uses diamond as absorber for…

At Argonne National Laboratory, we are developing hard X-ray (2 to 20 keV) Transition Edge Sensor (TES) arrays for beamline science. The significantly improved energy resolution provided by superconducting detectors compared to…

Instrumentation and Detectors · Physics 2021-06-02 T. Guruswamy , L. Gades , A. Miceli , U. Patel , O. Quaranta