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Identification of disease subtypes and corresponding biomarkers can substantially improve clinical diagnosis and treatment selection. Discovering these subtypes in noisy, high dimensional biomedical data is often impossible for humans and…

Quantitative Methods · Quantitative Biology 2020-05-18 Marc-Andre Schulz , Matt Chapman-Rounds , Manisha Verma , Danilo Bzdok , Konstantinos Georgatzis

We present a new way to summarize and select mixture models via the hierarchical clustering tree (dendrogram) constructed from an overfitted latent mixing measure. Our proposed method bridges agglomerative hierarchical clustering and…

Methodology · Statistics 2024-03-11 Dat Do , Linh Do , Scott A. McKinley , Jonathan Terhorst , XuanLong Nguyen

Drug synergy prediction is a critical task in the development of effective combination therapies for complex diseases, including cancer. Although existing methods have shown promising results, they often operate as black-box predictors that…

Machine Learning · Computer Science 2025-11-05 Yi Luo , Haochen Zhao , Xiao Liang , Yiwei Liu , Yuye Zhang , Xinyu Li , Jianxin Wang

Magnetic resonance imaging (MRI) is indispensable for diagnosing and planning treatment in various medical conditions due to its ability to produce multi-series images that reveal different tissue characteristics. However, integrating these…

Image and Video Processing · Electrical Eng. & Systems 2024-12-11 Churan Wang , Fei Gao , Lijun Yan , Siwen Wang , Yizhou Yu , Yizhou Wang

Finite mixture of skew distributions have emerged as an effective tool in modelling heterogeneous data with asymmetric features. With various proposals appearing rapidly in the recent years, which are similar but not identical, the…

Methodology · Statistics 2013-05-29 Sharon X. Lee , Geoffrey J. McLachlan

The proliferation of high-dimensional data from sources such as social media, sensor networks, and online platforms has created new challenges for clustering algorithms. Multi-view clustering, which integrates complementary information from…

Machine Learning · Computer Science 2026-01-23 Chakib Fettal , Lazhar Labiod , Mohamed Nadif

Do expert-defined or diagnostically-labeled data groups align with clusters inferred through statistical modeling? If not, where do discrepancies between predefined labels and model-based groupings occur and why? In this work, we introduce…

Methodology · Statistics 2026-03-18 Patricia Puchhammer , Ines Wilms , Peter Filzmoser

Multi-view clustering leverages consistent and complementary information across multiple views to provide more comprehensive insights than single-view analysis. However, the heterogeneity and redundancy of multi-view data pose significant…

Optimization and Control · Mathematics 2025-08-12 Xiangru Xing , Yan Li , Xin Wang , Huangyue Chen , Xianchao Xiu

Biclustering techniques have been widely used to identify homogeneous subgroups within large data matrices, such as subsets of genes similarly expressed across subsets of patients. Mining a max-sum sub-matrix is a related but distinct…

Machine Learning · Statistics 2017-09-26 Vincent Branders , Pierre Schaus , Pierre Dupont

We propose a mixture of latent trait models with common slope parameters (MCLT) for model-based clustering of high-dimensional binary data, a data type for which few established methods exist. Recent work on clustering of binary data, based…

Methodology · Statistics 2017-10-09 Yang Tang , Ryan P. Browne , Paul D. McNicholas

Feature selection methods are widely used to address the high computational overheads and curse of dimensionality in classifying high-dimensional data. Most conventional feature selection methods focus on handling homogeneous features,…

Machine Learning · Computer Science 2021-11-17 Xuyang Yan , Mrinmoy Sarkar , Biniam Gebru , Shabnam Nazmi , Abdollah Homaifar

Clustering is a class of unsupervised learning methods that has been extensively applied and studied in computer vision. Little work has been done to adapt it to the end-to-end training of visual features on large scale datasets. In this…

Computer Vision and Pattern Recognition · Computer Science 2019-03-19 Mathilde Caron , Piotr Bojanowski , Armand Joulin , Matthijs Douze

Recently, several clustering algorithms have been used to solve variety of problems from different discipline. This dissertation aims to address different challenging tasks in computer vision and pattern recognition by casting the problems…

Computer Vision and Pattern Recognition · Computer Science 2018-02-08 Yonatan Tariku Tesfaye

Clustering algorithms are pivotal in data analysis, enabling the organization of data into meaningful groups. However, individual clustering methods often exhibit inherent limitations and biases, preventing the development of a universal…

Neural and Evolutionary Computing · Computer Science 2024-12-13 H. Jahani , F. Zamio

Research on cluster analysis for categorical data continues to develop, with new clustering algorithms being proposed. However, in this context, the determination of the number of clusters is rarely addressed. In this paper, we propose a…

Methodology · Statistics 2014-09-29 Cláudia Silvestre , Margarida G. M. S. Cardoso , Mário A. T. Figueiredo

One of the promising methods for the treatment of complex diseases such as cancer is combinational therapy. Due to the combinatorial complexity, machine learning models can be useful in this field, where significant improvements have…

Machine Learning · Computer Science 2020-01-08 Işıksu Ekşioğlu , Mehmet Tan

Computational drug repositioning aims to discover new uses of drugs that have been marketed. However, the existing models suffer from the following limitations. Firstly, in the real world, only a minority of diseases have definite treatment…

Computational Engineering, Finance, and Science · Computer Science 2023-01-18 Xinxing Yang , Genke Yang , Jian Chu

Medical image analysis using supervised deep learning methods remains problematic because of the reliance of deep learning methods on large amounts of labelled training data. Although medical imaging data repositories continue to expand…

Computer Vision and Pattern Recognition · Computer Science 2019-06-11 Euijoon Ahn , Ashnil Kumar , Dagan Feng , Michael Fulham , Jinman Kim

We introduce and address a novel distributed clustering problem where each participant has a private dataset containing only a subset of all available features, and some features are included in multiple datasets. This scenario occurs in…

Data Structures and Algorithms · Computer Science 2025-10-14 Alessio Maritan , Luca Schenato

Real-world applications may be affected by outlying values. In the model-based clustering literature, several methodologies have been proposed to detect units that deviate from the majority of the data (rowwise outliers) and trim them from…