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Model-based clustering integrated with variable selection is a powerful tool for uncovering latent structures within complex data. However, its effectiveness is often hindered by challenges such as identifying relevant variables that define…

We study the clustering problem for mixtures of bounded covariance distributions, under a fine-grained separation assumption. Specifically, given samples from a $k$-component mixture distribution $D = \sum_{i =1}^k w_i P_i$, where each $w_i…

Machine Learning · Computer Science 2023-12-20 Ilias Diakonikolas , Daniel M. Kane , Jasper C. H. Lee , Thanasis Pittas

Clustering is one of the fundamental tasks in computer vision and pattern recognition. Recently, deep clustering methods (algorithms based on deep learning) have attracted wide attention with their impressive performance. Most of these…

Computer Vision and Pattern Recognition · Computer Science 2021-06-14 Yanhai Gan , Xinghui Dong , Huiyu Zhou , Feng Gao , Junyu Dong

The clustering of bounded data presents unique challenges in statistical analysis due to the constraints imposed on the data values. This paper introduces a novel method for model-based clustering specifically designed for bounded data.…

Methodology · Statistics 2025-05-16 Luca Scrucca

In this paper, we study the modeling and the classification of functional data presenting regime changes over time. We propose a new model-based functional mixture discriminant analysis approach based on a specific hidden process regression…

Methodology · Statistics 2013-12-30 Faicel Chamroukhi , Hervé Glotin , Allou Samé

Development of new medications is a very lengthy and costly process. Finding novel indications for existing drugs, or drug repositioning, can serve as a useful strategy to shorten the development cycle. In this study, we present an approach…

Genomics · Quantitative Biology 2017-12-13 Kai Zhao , Hon-Cheong So

This article presents a novel pretopology-based algorithm designed to address the challenges of clustering mixed data without the need for dimensionality reduction. Leveraging Disjunctive Normal Form, our approach formulates customizable…

Machine Learning · Computer Science 2025-12-04 Loup-Noe Levy , Guillaume Guerard , Sonia Djebali , Soufian Ben Amor

We consider high-dimensional regression over subgroups of observations. Our work is motivated by biomedical problems, where disease subtypes, for example, may differ with respect to underlying regression models, but sample sizes at the…

Until recently obtaining data on populations of networks was typically rare. However, with the advancement of automatic monitoring devices and the growing social and scientific interest in networks, such data has become more widely…

Methodology · Statistics 2020-01-22 Mirko Signorelli , Ernst Wit

Development of interpretable machine learning models for clinical healthcare applications has the potential of changing the way we understand, treat, and ultimately cure, diseases and disorders in many areas of medicine. These models can…

Machine Learning · Computer Science 2019-08-06 Qingzhu Gao , Humberto Gonzalez , Parvez Ahammad

We present neural mixture distributional regression (NMDR), a holistic framework to estimate complex finite mixtures of distributional regressions defined by flexible additive predictors. Our framework is able to handle a large number of…

Computation · Statistics 2020-10-15 David Rügamer , Florian Pfisterer , Bernd Bischl

Neural network-based clustering has recently gained popularity, and in particular a constrained clustering formulation has been proposed to perform transfer learning and image category discovery using deep learning. The core idea is to…

Computer Vision and Pattern Recognition · Computer Science 2018-06-29 Yen-Chang Hsu , Zhaoyang Lv , Joel Schlosser , Phillip Odom , Zsolt Kira

Case-based Reasoning (CBR) on high-dimensional and heterogeneous data is a trending yet challenging and computationally expensive task in the real world. A promising approach is to obtain low-dimensional hash codes representing cases and…

Information Retrieval · Computer Science 2022-06-30 Qi Zhang , Liang Hu , Chongyang Shi , Ke Liu , Longbing Cao

We introduce a novel profile-based patient clustering model designed for clinical data in healthcare. By utilizing a method grounded on constrained low-rank approximation, our model takes advantage of patients' clinical data and digital…

Machine Learning · Computer Science 2023-08-24 Dongjin Choi , Andy Xiang , Ozgur Ozturk , Deep Shrestha , Barry Drake , Hamid Haidarian , Faizan Javed , Haesun Park

This paper presents a new, parallel implementation of clustering and demonstrates its utility in greatly speeding up the process of identifying homologous proteins. Clustering is a technique to reduce the number of comparison needed to find…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-08-29 Stuart Byma , Akash Dhasade , Adrian Altenhoff , Christophe Dessimoz , James R. Larus

Due to the complexity of cancer, clustering algorithms have been used to disentangle the observed heterogeneity and identify cancer subtypes that can be treated specifically. While kernel based clustering approaches allow the use of more…

Machine Learning · Statistics 2018-11-21 Nora K. Speicher , Nico Pfeifer

Single-cell datasets often lack individual cell labels, making it challenging to identify cells associated with disease. To address this, we introduce Mixture Modeling for Multiple Instance Learning (MMIL), an expectation maximization…

Quantitative Methods · Quantitative Biology 2024-06-13 Erin Craig , Timothy Keyes , Jolanda Sarno , Maxim Zaslavsky , Garry Nolan , Kara Davis , Trevor Hastie , Robert Tibshirani

Selecting hyperparameters for unsupervised learning problems is challenging in general due to the lack of ground truth for validation. Despite the prevalence of this issue in statistics and machine learning, especially in clustering…

Machine Learning · Statistics 2020-02-04 Xinjie Fan , Yuguang Yue , Purnamrita Sarkar , Y. X. Rachel Wang

Understanding treatment effect heterogeneity is vital for scientific and policy research. However, identifying and evaluating heterogeneous treatment effects pose significant challenges due to the typically unknown subgroup structure.…

Methodology · Statistics 2024-11-05 Kwangho Kim , Jisu Kim , Larry A. Wasserman , Edward H. Kennedy

Model-based clustering approaches concern the paradigm of exploratory data analysis relying on the finite mixture model to automatically find a latent structure governing observed data. They are one of the most popular and successful…

Methodology · Statistics 2014-04-29 Faicel Chamroukhi