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Raman spectroscopy is widely applied to detect different chemical compounds in organic matter and create label-free high-resolution maps on the level of separate cells. The main advantage of this technique is the possibility to study…

Applied Physics · Physics 2025-01-15 Petr Shvets , Aleksandr Goikhman

Raman microscopy is a powerful method combining non-invasiveness with no special sample preparation. Because of this remarkable simplicity, it has been widely exploited in many fields, ranging from life and materials sciences, to…

Raman spectroscopy is one of the key techniques in the study of vibrational modes and molecular structures. In Coherent Anti-Stokes Raman Scattering (CARS) spectroscopy, a molecular vibrational spectrum is resolved via the third-order…

Optics · Physics 2010-12-02 Ori Katz , Jonathan M. Levitt , Eran Grinvald , Yaron Silberberg

Raman spectroscopy reveals chemically specific information and provides label-free insight into the molecular world. However, the signals are intrinsically weak and call for enhancement techniques. Here, we demonstrate Purcell enhancement…

Hydrogen detection is of great importance in chemical and energy industries. Optical fiber hydrogen sensors show flexibility and compactness and have the potential for distributed analysis. However, traditional fiber sensors encounter a…

Optics · Physics 2019-05-16 F. Yang , Y. Zhao , Y. Qi , Y. Z. Tan , H. L. Ho , W. Jin

Raman spectroscopy has been widely applied to the chemical analysis of food quality and, in particular, of chocolate. We perform Raman analysis of bloom formation in white and dark chocolates. We show evidence of sugar and fat bloom and…

Soft Condensed Matter · Physics 2016-12-05 Siyu He , Dmitri V. Voronine

Raman scattering spectroscopy is widely used as an analytical technique in various fields, but its measurement process tends to be slow due to the low scattering cross-section. In the last decade, various broadband coherent Raman scattering…

Optics · Physics 2025-05-06 Takuma Nakamura , Kazuki Hashimoto , Takuro Ideguchi

Strain engineering in semiconductor transistor devices has become vital in the semiconductor industry due to the ever increasing need for performance enhancement at the nanoscale. Raman spectroscopy is a non-invasive measurement technique…

Optics · Physics 2021-06-17 V. Prabhakara , T. Nuytten , H. Bender , W. Vandervorst , S. Bals , J. Verbeeck

Optical spectroscopy and imaging of microscopic samples have opened up a wide range of applications throughout the physical, chemical, and biological sciences. High chemical specificity may be achieved by directly interrogating the…

Raman spectroscopy can be used to identify molecules such as DNA by the characteristic scattering of light from a laser. It is sensitive at very low concentrations and can accurately quantify the amount of a given molecule in a sample. The…

Applications · Statistics 2026-02-03 Matthew Moores , Kirsten Gracie , Jake Carson , Karen Faulds , Duncan Graham , Mark Girolami

Spectro-microscopy is an experimental technique which can be used to observe spatial variations in chemical state and changes in chemical state over time or under experimental conditions. As a result it has broad applications across areas…

Medical Physics · Physics 2026-02-05 Maike Meier , Lorenzo Lazzarino , Boris Shustin , Hussam Al Daas , Paul Quinn

Optical spectroscopy is an important and widely used technique, for instance, to characterize new materials and to identify unknown compounds. Spectra are typically reported as a function of the wavelength of light, yet the information…

Optics · Physics 2026-05-06 Erik F. Woering , Richard Hildner

Ultrafast lasers have become one of the most powerful tools in coherent nonlinear optical spectroscopy. Short pulses enable direct observation of fast molecular dynamics, whereas broad spectral bandwidth offers ways of controlling nonlinear…

Chemical Physics · Physics 2015-05-13 X. G. Xu , S. O. Konorov , J. W. Hepburn , V. Milner

Nonlinear optical microscopy allows rapid high-resolution microscopy with image contrast generated from intrinsic properties of the sample. Established modalities such as multiphoton excited fluorescence and second/third-harmonic generation…

Raman spectroscopy in combination with machine learning has significant promise for applications in clinical settings as a rapid, sensitive, and label-free identification method. These approaches perform well in classifying data that…

Machine Learning · Computer Science 2021-11-12 Yaroslav Balytskyi , Justin Bendesky , Tristan Paul , Guy Hagen , Kelly McNear

Vibrational micro-spectroscopy is a powerful optical tool, providing a non-invasive label-free chemically specific imaging for many chemical and biomedical applications. However, hyperspectral image produced by Raman micro-spectroscopy…

Computational Physics · Physics 2019-03-12 E. G. Lobanova , S. V. Lobanov

We show that combining vibrational spectroscopy with signal processing can result in a scheme for ultrasensitive detection of molecules. We consider the vibrational spectrum as a signal on the energy axis and apply a matched filter on that…

Computational Physics · Physics 2018-12-10 Tay Yong Boon , Ian Tay Rongde , Loy Liang Yi , Aw Ke Fun , Ong Zhi Li , Sergei Manzhos

Raman spectroscopy is a promising tool for microbial identification, yet its implementation in microbiology and clinical workflow is still restricted due to the accompanying additional preparation required to focus on microbial signals.…

Quantitative Methods · Quantitative Biology 2026-03-19 Jeong Hee Kim , Jia Dong , Marissa Morales , Loza Tadesse

In chemical processing and bioprocessing, conventional online sensors are limited to measure only basic process variables like pressure and temperature, pH, dissolved O and CO$_2$ and viable cell density (VCD). The concentration of other…

Quantitative Methods · Quantitative Biology 2020-05-07 Semion Rozov

We demonstrate a novel technique of coherent Raman spectroscopy with a femtosecond laser. We apply to a molecular sample a sequence of pairs of ultrashort excitation and probe pulses, with a linearly increasing time delay between the two…