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Unrolled neural networks have recently achieved state-of-the-art accelerated MRI reconstruction. These networks unroll iterative optimization algorithms by alternating between physics-based consistency and neural-network based…

Image and Video Processing · Electrical Eng. & Systems 2022-07-19 Batu Ozturkler , Arda Sahiner , Tolga Ergen , Arjun D Desai , Christopher M Sandino , Shreyas Vasanawala , John M Pauly , Morteza Mardani , Mert Pilanci

In cryo-electron microscopy (EM), molecular structures are determined from large numbers of projection images of individual particles. To harness the full power of this single-molecule information, we use the Bayesian inference of EM…

Biomolecules · Quantitative Biology 2018-01-17 Pilar Cossio , David Rohr , Fabio Baruffa , Markus Rampp , Volker Lindenstruth , Gerhard Hummer

Cryogenic Electron Tomography (CryoET) combined with sub-volume averaging (SVA) is the only imaging modality capable of resolving protein structures inside cells at molecular resolution. Particle picking, the task of localizing and…

Computer Vision and Pattern Recognition · Computer Science 2026-01-14 Linhan Wang , Jianwen Dou , Wang Li , Shengkun Wang , Zhiwu Xie , Chang-Tien Lu , Yinlin Chen

Automated and semi-automated techniques in biomedical electron microscopy (EM) enable the acquisition of large datasets at a high rate. Segmentation methods are therefore essential to analyze and interpret these large volumes of data, which…

Computer Vision and Pattern Recognition · Computer Science 2023-08-08 Anusha Aswath , Ahmad Alsahaf , Ben N. G. Giepmans , George Azzopardi

Comprehensive, synapse-resolution imaging of the brain will be crucial for understanding neuronal computations and function. In connectomics, this has been the sole purview of volume electron microscopy (EM), which entails an excruciatingly…

Image and Video Processing · Electrical Eng. & Systems 2023-03-03 Yicong Li , Yaron Meirovitch , Aaron T. Kuan , Jasper S. Phelps , Alexandra Pacureanu , Wei-Chung Allen Lee , Nir Shavit , Lu Mi

Quantitative microstructural characterization is fundamental to materials science, where electron micrograph (EM) provides indispensable high-resolution insights. However, progress in deep learning-based EM characterization has been…

Computer Vision and Pattern Recognition · Computer Science 2025-08-25 Nan wang , Zhiyi Xia , Yiming Li , Shi Tang , Zuxin Fan , Xi Fang , Haoyi Tao , Xiaochen Cai , Guolin Ke , Linfeng Zhang , Yanhui Hong

Cryo-electron microscopy (cryo-EM) is unique among tools in structural biology in its ability to image large, dynamic protein complexes. Key to this ability is image processing algorithms for heterogeneous cryo-EM reconstruction, including…

Quantitative Methods · Quantitative Biology 2022-11-28 Karsten Kreis , Tim Dockhorn , Zihao Li , Ellen Zhong

Automated sample preparation and electron microscopy enables acquisition of very large image data sets. These technical advances are of special importance to the field of neuroanatomy, as 3D reconstructions of neuronal processes at the nm…

We consider the multi-target detection problem of recovering a set of signals that appear multiple times at unknown locations in a noisy measurement. In the low noise regime, one can estimate the signals by first detecting occurrences, then…

Information Theory · Computer Science 2020-01-08 Tamir Bendory , Nicolas Boumal , William Leeb , Eitan Levin , Amit Singer

We presented a new 3D refinement method for Cryo-EM single particle analysis which can improve the resolution of final electron density map in this paper. We proposed to enforce both sparsity and smoothness to improve the regularity of…

Image and Video Processing · Electrical Eng. & Systems 2020-03-12 Zhenwei Luo

In the tasks of image aesthetic quality evaluation, it is difficult to reach both the high score area and low score area due to the normal distribution of aesthetic datasets. To reduce the error in labeling and solve the problem of normal…

Computer Vision and Pattern Recognition · Computer Science 2022-01-11 Xin Jin , Hao Lou , Huang Heng , Xiaodong Li , Shuai Cui , Xiaokun Zhang , Xiqiao Li

We target the problem of estimating the center of mass of noisy 2-D images. We assume that the noise dominates the image, and thus many standard approaches are vulnerable to estimation errors. Our approach uses a surrogate function to the…

Image and Video Processing · Electrical Eng. & Systems 2021-03-04 Ayelet Heimowitz , Nir Sharon , Amit Singer

From AlexNet to Inception, autoencoders to diffusion models, the development of novel and powerful deep learning models and learning algorithms has proceeded at breakneck speeds. In part, we believe that rapid iteration of model…

Computational Engineering, Finance, and Science · Computer Science 2022-11-17 Shehtab Zaman , Ethan Ferguson , Cecile Pereira , Denis Akhiyarov , Mauricio Araya-Polo , Kenneth Chiu

Currently, the telehealth monitoring field has gained huge attention due to its noteworthy use in day-to-day life. This advancement has led to an increase in the data collection of electrophysiological signals. Due to this advancement,…

Signal Processing · Electrical Eng. & Systems 2023-03-29 Raghavendra Badiger , M. Prabhakar

Deformable medical image registration is a fundamental task in medical image analysis with applications in disease diagnosis, treatment planning, and image-guided interventions. Despite significant advances in deep learning based…

Machine Learning · Computer Science 2026-02-10 Muhammad Zafar Iqbal , Ghazanfar Farooq Siddiqui , Anwar Ul Haq , Imran Razzak

Computed Tomography (CT) image reconstruction is crucial for accurate diagnosis and deep learning approaches have demonstrated significant potential in improving reconstruction quality. However, the choice of loss function profoundly…

Image and Video Processing · Electrical Eng. & Systems 2024-03-19 Yipeng Sun , Yixing Huang , Linda-Sophie Schneider , Mareike Thies , Mingxuan Gu , Siyuan Mei , Siming Bayer , Andreas Maier

Particle picking is a crucial first step in the computational pipeline of single-particle cryo-electron microscopy (cryo-EM). Selecting particles from the micrographs is difficult especially for small particles with low contrast. As…

Computer Vision and Pattern Recognition · Computer Science 2018-08-06 Ayelet Heimowitz , Joakim Andén , Amit Singer

Particle picking is currently a critical step in the cryo-electron microscopy single particle reconstruction pipeline. Contaminations in the acquired micrographs severely degrade the performance of particle pickers, resulting is many…

Computer Vision and Pattern Recognition · Computer Science 2022-01-19 Amitay Eldar , Ido Amos , Yoel Shkolnisky

Micro-expression has emerged as a promising modality in affective computing due to its high objectivity in emotion detection. Despite the higher recognition accuracy provided by the deep learning models, there are still significant scope…

Computer Vision and Pattern Recognition · Computer Science 2022-01-25 Viswanatha Reddy Gajjala , Sai Prasanna Teja Reddy , Snehasis Mukherjee , Shiv Ram Dubey

The inability to acquire clean high-resolution (HR) electron microscopy (EM) images over a large brain tissue volume hampers many neuroscience studies. To address this challenge, we propose a deep-learning-based image super-resolution (SR)…

Computer Vision and Pattern Recognition · Computer Science 2024-01-29 Mohammad Khateri , Morteza Ghahremani , Alejandra Sierra , Jussi Tohka