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In the present paper, progression of non-alcoholic fatty liver disease (NAFLD) process is modeled by Continuous time Markov chains (CTMC) with 4 states .The transition intensities among the states are estimated using maximum likelihood…

Applications · Statistics 2021-11-18 Iman Mohammed Attia Abd-Elkhalik Abo-Elreesh

In this paper we present a novel method for estimating the parameters of a parametric diffusion processes. Our approach is based on a closed-form Maximum Likelihood estimator for an approximating Continuous Time Markov Chain (CTMC) of the…

Methodology · Statistics 2021-08-31 J. L. Kirkby , Dang Nguyen , Duy Nguyen , Nhu Nguyen

The paper has two objectives: proving that the rate of convergence in distribution for mean-field models in CLT regime is $N^{-1/2}$, and obtaining explicit expressions for the infinitesimal generators of two types of measure-valued Markov…

Probability · Mathematics 2025-02-05 Xavier Erny

Computing smoothing distributions, the distributions of one or more states conditional on past, present, and future observations is a recurring problem when operating on general hidden Markov models. The aim of this paper is to provide a…

Probability · Mathematics 2012-02-15 Randal Douc , Aurélien Garivier , Eric Moulines , Jimmy Olsson

Graph dynamical systems (GDS) model dynamic processes on a (static) graph. Stochastic GDS has been used for network-based epidemics models such as the contact process and the reversible contact process. In this paper, we consider stochastic…

Applications · Statistics 2023-03-16 Seyyed A. Fatemi , June Zhang

Sampling all possible transition paths between two 3D states of a molecular system has various applications ranging from catalyst design to drug discovery. Current approaches to sample transition paths use Markov chain Monte Carlo and rely…

Quantitative Methods · Quantitative Biology 2024-05-29 Michael Plainer , Hannes Stärk , Charlotte Bunne , Stephan Günnemann

Many biological and medical questions can be modeled using time-to-event data in finite-state Markov chains, with the phase-type distribution describing intervals between events. We solve the inverse problem: given a phase-type…

Dynamical Systems · Mathematics 2024-11-19 Ovidiu Radulescu , Dima Grigoriev , Matthias Seiss , Maria Douaihy , Mounia Lagha , Edouard Bertrand

Branching processes are a class of continuous-time Markov chains (CTMCs) with ubiquitous applications. A general difficulty in statistical inference under partially observed CTMC models arises in computing transition probabilities when the…

Computation · Statistics 2015-03-10 Jason Xu , Vladimir N. Minin

Learning a transport model that maps a source distribution to a target distribution is a canonical problem in machine learning, but scientific applications increasingly require models that can generalize to source and target distributions…

Machine Learning · Computer Science 2026-03-06 Nic Fishman , Gokul Gowri , Paolo L. B. Fischer , Marinka Zitnik , Omar Abudayyeh , Jonathan Gootenberg

We introduce a general framework for deriving effective dynamics from arbitrary time-dependent generators, based on a systematic operator cumulant expansion. Unlike traditional approaches, which typically assume periodic or adiabatic…

Mathematical Physics · Physics 2025-10-02 Leon Bello , Tal Rubin , Wentao Fan , Nathaniel Fisch , Hakan Türeci

Generalized mode-coupling theory (GMCT) constitutes a systematically correctable, first-principles theory to study the dynamics of supercooled liquids and the glass transition. It is a hierarchical framework that, through the incorporation…

Statistical Mechanics · Physics 2021-02-03 Chengjie Luo , Liesbeth M. C. Janssen

A Markov chain update scheme using a machine-learned flow-based generative model is proposed for Monte Carlo sampling in lattice field theories. The generative model may be optimized (trained) to produce samples from a distribution…

High Energy Physics - Lattice · Physics 2019-09-10 M. S. Albergo , G. Kanwar , P. E. Shanahan

Diffusion approximations are widely used in the analysis of service systems, providing tractable insights into complex models. While heavy-traffic limit theorems justify these approximations asymptotically, they do not quantify the error…

Probability · Mathematics 2025-03-18 Anton Braverman , Ziv Scully

Continuous diffusion models have demonstrated remarkable performance in data generation across various domains, yet their efficiency remains constrained by two critical limitations: (1) the local adjacency structure of the forward Markov…

Machine Learning · Statistics 2025-05-29 Xunpeng Huang , Yingyu Lin , Nikki Lijing Kuang , Hanze Dong , Difan Zou , Yian Ma , Tong Zhang

We describe a random matrix approach that can provide generic and readily soluble mean-field descriptions of the phase diagram for a variety of systems ranging from QCD to high-T_c materials. Instead of working from specific models, phase…

High Energy Physics - Phenomenology · Physics 2015-05-28 Benoit Vanderheyden , A D Jackson

Stochastic Event Timing is a fundamental issue in developing both analytic and simulation models for stochastic systems. Generalized Erlang distributions are quite useful for generating those random events in a quite general way by…

Systems and Control · Electrical Eng. & Systems 2019-12-02 Carlos-Andrey Maia

We extend the Langevin Monte Carlo (LMC) algorithm to compactly supported measures via a projection step, akin to projected Stochastic Gradient Descent (SGD). We show that (projected) LMC allows to sample in polynomial time from a…

Probability · Mathematics 2016-08-08 Sébastien Bubeck , Ronen Eldan , Joseph Lehec

Due to their dynamic properties such as irregular sampling rate and high-frequency sampling, Continuous Time Series (CTS) are found in many applications. Since CTS with irregular sampling rate are difficult to model with standard Recurrent…

Machine Learning · Computer Science 2025-03-13 C. Coelho , M. Fernanda P. Costa , L. L. Ferrás

Many real-world phenomena can be modelled as dynamical processes on networks, a prominent example being the spread of infectious diseases such as COVID-19. Mean-field approximations are a widely used tool to analyse such dynamical processes…

Probability · Mathematics 2025-08-25 Jonathan A. Ward , Gábor Timár , Péter L. Simon

Phase-type distribution has been an important probabilistic tool in the analysis of complex stochastic system evolution. It was introduced by Neuts \cite{Neuts1975} in 1975. The model describes the lifetime distribution of a finite-state…

Methodology · Statistics 2016-11-14 B. A. Surya