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We present two Bayesian procedures to infer the interactions and external currents in an assembly of stochastic integrate-and-fire neurons from the recording of their spiking activity. The first procedure is based on the exact calculation…

Machine Learning · Statistics 2011-02-28 Remi Monasson , Simona Cocco

Neural circuits contain heterogeneous groups of neurons that differ in type, location, connectivity, and basic response properties. However, traditional methods for dimensionality reduction and clustering are ill-suited to recovering the…

Machine Learning · Statistics 2016-10-27 Scott W. Linderman , Ryan P. Adams , Jonathan W. Pillow

Bayesian sociality models provide a scalable and flexible alternative for network analysis, capturing degree heterogeneity through actor-specific parameters while mitigating the identifiability challenges of latent space models. This paper…

Methodology · Statistics 2025-03-20 Juan Sosa , Carlo Martínez

Hawkes process provides an effective statistical framework for analyzing the time-dependent interaction of neuronal spiking activities. Although utilized in many real applications, the classic Hawkes process is incapable of modelling…

Machine Learning · Statistics 2021-02-23 Feng Zhou , Yixuan Zhang , Jun Zhu

Recent technological advances have made it possible to simultaneously measure multiple protein activities at the single cell level. With such data collected under different stimulatory or inhibitory conditions, it is possible to infer the…

Applications · Statistics 2011-08-04 Ruiyan Luo , Hongyu Zhao

Background: Current neuronal monitoring techniques, such as calcium imaging and multi-electrode arrays, enable recordings of spiking activity from hundreds of neurons simultaneously. Of primary importance in systems neuroscience is the…

Neurons and Cognition · Quantitative Biology 2014-11-11 Yazan N. Billeh , Michael T. Schaub , Costas A. Anastassiou , Mauricio Barahona , Christof Koch

The analysis of data from multiple experiments, such as observations of several individuals, is commonly approached using mixed-effects models, which account for variation between individuals through hierarchical representations. This makes…

Computation · Statistics 2026-03-05 Henrik Häggström , Sebastian Persson , Marija Cvijovic , Umberto Picchini

Bayesian neural networks (BNNs) have recently regained a significant amount of attention in the deep learning community due to the development of scalable approximate Bayesian inference techniques. There are several advantages of using a…

Machine Learning · Statistics 2023-05-02 Aliaksandr Hubin , Geir Storvik

The analysis of EEG/MEG functional connectivity has become an important tool in neural research. Especially the high time resolution of EEG/MEG enables important insight into the functioning of the human brain. To date, functional…

Signal Processing · Electrical Eng. & Systems 2023-03-07 Lorenz Esch , Jinlong Dong , Matti Hämäläinen , Daniel Baumgarten , Jens Haueisen , Johannes Vorwerk

A pervasive challenge in neuroscience is testing whether neuronal connectivity changes over time due to specific causes, such as stimuli, events, or clinical interventions. Recent hardware innovations and falling data storage costs enable…

Neurons and Cognition · Quantitative Biology 2024-01-05 Johan Medrano , Karl J. Friston , Peter Zeidman

We present a Bayesian approach for modeling multivariate, dependent functional data. To account for the three dominant structural features in the data--functional, time dependent, and multivariate components--we extend hierarchical dynamic…

Methodology · Statistics 2019-07-02 Daniel R. Kowal , David S. Matteson , David Ruppert

Analyzing and understanding the structure of complex relational data is important in many applications including analysis of the connectivity in the human brain. Such networks can have prominent patterns on different scales, calling for a…

Machine Learning · Statistics 2013-11-22 Mikkel N. Schmidt , Tue Herlau , Morten Mørup

In many applications, smooth processes generate data that is recorded under a variety of observation regimes, such as dense, sparse or fragmented observations that are often contaminated with error. The statistical goal of registering and…

Applications · Statistics 2019-12-12 James Matuk , Karthik Bharath , Oksana Chkrebtii , Sebastian Kurtek

In modern applications such as ECG monitoring, neuroimaging, wearable sensing, and industrial equipment diagnostics, complex and continuously structured data are ubiquitous, presenting both challenges and opportunities for functional data…

Machine Learning · Computer Science 2026-03-03 Xiaoxian Zhu , Yingmeng Li , Shuangge Ma , Mengyun Wu

A central issue in neural recording is that of distinguishing the activities of many neurons. Here, we develop a framework, based on Fisher information, to quantify how separable a neuron's activity is from the activities of nearby neurons.…

A vast majority of spiking neural networks (SNNs) are trained based on inductive biases that are not necessarily a good fit for several critical tasks that require low-latency and power efficiency. Inferring brain behavior based on the…

Neural and Evolutionary Computing · Computer Science 2023-04-20 Xi Chen , Siwei Mai , Konstantinos Michmizos

In the literature on deep neural networks, there is considerable interest in developing activation functions that can enhance neural network performance. In recent years, there has been renewed scientific interest in proposing activation…

Machine Learning · Computer Science 2023-04-20 Mohamed Fakhfakh , Lotfi Chaari

Most functional magnetic resonance imaging studies rely on estimates of hierarchically organized functional brain networks whose segregation and integration reflect the cognitive and behavioral changes in humans. However, most existing…

Neurons and Cognition · Quantitative Biology 2026-04-17 Lingbin Bian , Nizhuan Wang , Leonardo Novelli , Jonathan Keith , Adeel Razi

An increasing body of evidence suggests that the trial-to-trial variability of spiking activity in the brain is not mere noise, but rather the reflection of a sampling-based encoding scheme for probabilistic computing. Since the precise…

We apply an information theoretic treatment of action potential time series measured with microelectrode arrays to estimate the connectivity of mammalian neuronal cell assemblies grown {\it in vitro}. We infer connectivity between two…

Neurons and Cognition · Quantitative Biology 2007-05-23 Luis M. A. Bettencourt , Greg J. Stephens , Michael I. Ham , Guenter W. Gross