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Sequential neuronal activity underlies a wide range of processes in the brain. Neuroscientific evidence for neuronal sequences has been reported in domains as diverse as perception, motor control, speech, spatial navigation and memory.…

Adaptation and Self-Organizing Systems · Physics 2020-04-03 Sascha Frölich , Dimitrije Marković , Stefan J. Kiebel

Structural and functional neuroimaging modalities provide complementary windows into brain organization: structural imaging characterizes neural tissue anatomy and microstructure, while functional imaging captures dynamic patterns of neural…

Methodology · Statistics 2026-03-24 Sakul Mahat , Sharmistha Guha , Jessica Bernard

Brain responses related to working memory originate from distinct brain areas and oscillate at different frequencies. EEG signals with high temporal correlation can effectively capture these responses. Therefore, estimating the functional…

Machine Learning · Computer Science 2024-05-01 Harshini Gangapuram , Vidya Manian

Multi-Electrode Arrays (MEAs) have been widely used to record neuronal activities, which could be used in the diagnosis of gene defects and drug effects. In this paper, we address the problem of classifying in vitro MEA recordings of mouse…

Neurons and Cognition · Quantitative Biology 2019-06-07 Yun Zhao , Elmer Guzman , Morgane Audouard , Zhuowei Cheng , PaulK. Hansma , Kenneth S. Kosik , Linda Petzold

Understanding how neurons coordinate their activity is a fundamental question in neuroscience, with implications for learning, memory, and neurological disorders. Calcium imaging has emerged as a powerful method to observe large-scale…

Methodology · Statistics 2026-03-03 Laura D'Angelo , Francesco Denti , Antonio Canale , Michele Guindani

In this paper, we develop a graphical modeling framework for the inference of networks across multiple sample groups and data types. In medical studies, this setting arises whenever a set of subjects, which may be heterogeneous due to…

Network inference has been extensively studied in several fields, such as systems biology and social sciences. Learning network topology and internal dynamics is essential to understand mechanisms of complex systems. In particular, sparse…

Machine Learning · Statistics 2022-06-13 Yasen Wang , Junyang Jin , Jorge Goncalves

Our interest is in multiplex network data with multiple network samples observed across the same set of nodes. Examples originate from a variety of fields, including brain connectivity, international trade networks, and social networks,…

Methodology · Statistics 2026-04-21 Yuren Zhou , Yuqi Gu , David B. Dunson

Networks - collections of interacting elements or nodes - abound in the natural and manmade worlds. For many networks, complex spatiotemporal dynamics stem from patterns of physical interactions unknown to us. To infer these interactions,…

Quantitative Methods · Quantitative Biology 2015-05-13 Mark A. Kramer , Uri T. Eden , Sydney S. Cash , Eric D. Kolaczyk

Objective: Sparse Bayesian learning provides an effective scheme to solve the high-dimensional problem in brain signal decoding. However, traditional assumptions regarding data distributions such as Gaussian and binomial are potentially…

Signal Processing · Electrical Eng. & Systems 2025-08-19 Yuanhao Li , Badong Chen , Wenjun Bai , Yasuharu Koike , Okito Yamashita

Recently, there has been increased interest in fusing multimodal imaging to better understand brain organization. Specifically, accounting for knowledge of anatomical pathways connecting brain regions should lead to desirable outcomes such…

Applications · Statistics 2018-03-02 Ixavier A. Higgins , Suprateek Kundu , Ying Guo

Models of neural networks have proven their utility in the development of learning algorithms in computer science and in the theoretical study of brain dynamics in computational neuroscience. We propose in this paper a spatial neural…

Neural and Evolutionary Computing · Computer Science 2014-05-06 Lucas Antiqueira , Liang Zhao

Fluorescence Microcopy Calcium Imaging is a fundamental tool to in-vivo record and analyze large scale neuronal activities simultaneously at a single cell resolution. Automatic and precise detection of behaviorally relevant neuron activity…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Ran Li , Pan Xiao , Kaushik Dutta , Youdong Guo

Understanding the functioning of a neural system in terms of its underlying circuitry is an important problem in neuroscience. Recent developments in electrophysiology and imaging allow one to simultaneously record activities of hundreds of…

Databases · Computer Science 2008-03-11 Debprakash Patnaik , P. S. Sastry , K. P. Unnikrishnan

In this article, we propose an adapted sequential Monte Carlo approximate Bayesian computation (SMC-ABC) algorithm for network inference in coupled stochastic differential equations (SDEs) used for multivariate time series modeling. Our…

Methodology · Statistics 2025-08-27 Susanne Ditlevsen , Massimiliano Tamborrino , Irene Tubikanec

One of the main current issues in Neurobiology concerns the understanding of interrelated spiking activity among multineuronal ensembles and differences between stimulus-driven and spontaneous activity in neurophysiological experiments.…

Neurons and Cognition · Quantitative Biology 2017-10-13 Ludmila Brochini , Antonio Galves , Pierre Hodara , Guilherme Ost , Christophe Pouzat

Network inference has been attracting increasing attention in several fields, notably systems biology, control engineering and biomedicine. To develop a therapy, it is essential to understand the connectivity of biochemical units and the…

Systems and Control · Electrical Eng. & Systems 2024-12-20 Junyang Jin , Ye Yuan , Jorge Goncalves

We propose a scalable semiparametric Bayesian model to capture dependencies among multiple neurons by detecting their co-firing (possibly with some lag time) patterns over time. After discretizing time so there is at most one spike at each…

Applications · Statistics 2015-06-22 Babak Shahbaba , Bo Zhou , Shiwei Lan , Hernando Ombao , David Moorman , Sam Behseta

Neuro-inspired models and systems have great potential for applications in unconventional computing. Often, the mechanisms of biological neurons are modeled or mimicked in simulated or physical systems in an attempt to harness some of the…

Neural and Evolutionary Computing · Computer Science 2021-10-18 Jørgen Jensen Farner , Håkon Weydahl , Ruben Jahren , Ola Huse Ramstad , Stefano Nichele , Kristine Heiney

Multivariate functional data arise in a wide range of applications. One fundamental task is to understand the causal relationships among these functional objects of interest, which has not yet been fully explored. In this article, we…

Methodology · Statistics 2022-10-25 Fangting Zhou , Kejun He , Kunbo Wang , Yanxun Xu , Yang Ni