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Artificial Intelligence (AI) has continued to achieve tremendous success in recent times. However, the decision logic of these frameworks is often not transparent, making it difficult for stakeholders to understand, interpret or explain…

Machine Learning · Computer Science 2025-01-20 Fuseini Mumuni , Alhassan Mumuni

There has been a recent resurgence in the area of explainable artificial intelligence as researchers and practitioners seek to make their algorithms more understandable. Much of this research is focused on explicitly explaining decisions or…

Artificial Intelligence · Computer Science 2018-08-16 Tim Miller

The recent spike in certified Artificial Intelligence (AI) tools for healthcare has renewed the debate around adoption of this technology. One thread of such debate concerns Explainable AI and its promise to render AI devices more…

Human-Computer Interaction · Computer Science 2022-07-01 Giovanni Cinà , Tabea Röber , Rob Goedhart , Ilker Birbil

Artificial Intelligence/Machine Learning techniques have been widely used in software engineering to improve developer productivity, the quality of software systems, and decision-making. However, such AI/ML models for software engineering…

Software Engineering · Computer Science 2020-12-04 Chakkrit Tantithamthavorn , Jirayus Jiarpakdee , John Grundy

Human reasoning can distill principles from observed patterns and generalize them to explain and solve novel problems. The most powerful artificial intelligence systems lack explainability and symbolic reasoning ability, and have therefore…

Machine Learning · Computer Science 2021-11-17 Paul J. Blazek , Kesavan Venkatesh , Milo M. Lin

There is a growing concern about typically opaque decision-making with high-performance machine learning algorithms. Providing an explanation of the reasoning process in domain-specific terms can be crucial for adoption in risk-sensitive…

Computer Vision and Pattern Recognition · Computer Science 2022-11-28 Aditya Chattopadhyay , Stewart Slocum , Benjamin D. Haeffele , Rene Vidal , Donald Geman

While deep learning models have demonstrated remarkable success in numerous domains, their black-box nature remains a significant limitation, especially in critical fields such as medical image analysis and inference. Existing…

Machine Learning · Computer Science 2025-05-13 David Zucker

Deep learning has become a powerful tool in computational biology, revolutionising the analysis and interpretation of biological data over time. In our article review, we delve into various aspects of deep learning in computational biology.…

The task here is to predict the toxicological activity of chemical compounds based on the Tox21 dataset, a benchmark in computational toxicology. After a domain-specific overview of chemical toxicity, we discuss current computational…

Machine Learning · Computer Science 2025-10-28 Eduard Popescu , Adrian Groza , Andreea Cernat

Since Artificial Intelligence (AI) software uses techniques like deep lookahead search and stochastic optimization of huge neural networks to fit mammoth datasets, it often results in complex behavior that is difficult for people to…

Artificial Intelligence · Computer Science 2018-10-16 Daniel S. Weld , Gagan Bansal

The integration of artificial intelligence (AI) into medicine is remarkable, offering advanced diagnostic and therapeutic possibilities. However, the inherent opacity of complex AI models presents significant challenges to their clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Binbin Wen , Yihang Wu , Tareef Daqqaq , Ahmad Chaddad

Text-based representations of chemicals and proteins can be thought of as unstructured languages codified by humans to describe domain-specific knowledge. Advances in natural language processing (NLP) methodologies in the processing of…

Biomolecules · Quantitative Biology 2020-02-17 Hakime Öztürk , Arzucan Özgür , Philippe Schwaller , Teodoro Laino , Elif Ozkirimli

Knowledge-augmented learning enables the combination of knowledge-based and data-driven approaches. For anomaly detection and diagnosis, understandability is typically an important factor, especially in high-risk areas. Therefore,…

Machine Learning · Computer Science 2024-12-03 Martin Atzmueller , Tim Bohne , Patricia Windler

Deep Learning is a state-of-the-art technique to make inference on extensive or complex data. As a black box model due to their multilayer nonlinear structure, Deep Neural Networks are often criticized to be non-transparent and their…

Artificial Intelligence · Computer Science 2019-11-28 Vanessa Buhrmester , David Münch , Michael Arens

Deep Learning (DL) algorithms hold great promise for applications in the field of computational biophysics. In fact, the vast amount of available molecular structures, as well as their notable complexity, constitutes an ideal context in…

Soft Condensed Matter · Physics 2019-01-07 Marco Giulini , Raffaello Potestio

Artificial Intelligence (AI) has become an integral part of domains such as security, finance, healthcare, medicine, and criminal justice. Explaining the decisions of AI systems in human terms is a key challenge--due to the high complexity…

Artificial Intelligence · Computer Science 2019-11-25 Sheikh Rabiul Islam , William Eberle , Sheikh K. Ghafoor

Deep neural networks (DNNs) have become a proven and indispensable machine learning tool. As a black-box model, it remains difficult to diagnose what aspects of the model's input drive the decisions of a DNN. In countless real-world…

Machine Learning · Computer Science 2021-09-14 Gabrielle Ras , Ning Xie , Marcel van Gerven , Derek Doran

In the rapidly growing literature on explanation algorithms, it often remains unclear what precisely these algorithms are for and how they should be used. In this position paper, we argue for a novel and pragmatic perspective: Explainable…

Machine Learning · Computer Science 2025-06-17 Sebastian Bordt , Eric Raidl , Ulrike von Luxburg

Advancements in high-throughput technologies have led to a shift from traditional hypothesis-driven methodologies to data-driven approaches. Multi-omics refers to the integrative analysis of data derived from multiple 'omes', such as…

Genomics · Quantitative Biology 2024-10-17 Ahmad Hussein , Mukesh Prasad , Ali Braytee

Although current deep models for face tasks surpass human performance on some benchmarks, we do not understand how they work. Thus, we cannot predict how it will react to novel inputs, resulting in catastrophic failures and unwanted biases…

Computer Vision and Pattern Recognition · Computer Science 2023-09-27 Thrupthi Ann John , Vineeth N Balasubramanian , C. V. Jawahar
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