English
Related papers

Related papers: Machine-Learning Driven Drug Repurposing for COVID…

200 papers

With the fast development of COVID-19 into a global pandemic, scientists around the globe are desperately searching for effective antiviral therapeutic agents. Bridging systems biology and drug discovery, we propose a deep learning…

Quantitative Methods · Quantitative Biology 2020-11-24 Jannis Born , Matteo Manica , Joris Cadow , Greta Markert , Nil Adell Mill , Modestas Filipavicius , María Rodríguez Martínez

COVID-19 is a devastating respiratory and inflammatory illness caused by a new coronavirus that is rapidly spreading throughout the human population. Over the past 6 months, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the…

The novel coronavirus disease, named COVID-19, emerged in China in December 2019, and has rapidly spread around the world. It is clearly urgent to fight COVID-19 at global scale. The development of methods for identifying drug uses based on…

Quantitative Methods · Quantitative Biology 2021-10-06 Lu Han , G. C. Shan , B. F. Chu , H. Y. Wang , Z. J. Wang , S. Q. Gao , W. X. Zhou

Researchers across the globe are seeking to rapidly repurpose existing drugs or discover new drugs to counter the the novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). One promising…

The SARS-CoV-2 pandemic has created a global race for a cure. One approach focuses on designing a novel variant of the human angiotensin-converting enzyme 2 (ACE2) that binds more tightly to the SARS-CoV-2 spike protein and diverts it from…

The Coronavirus Disease 2019 (COVID-19) pandemic has infected over 10 million people globally with a relatively high mortality rate. There are many therapeutics undergoing clinical trials, but there is no effective vaccine or therapy for…

Molecular Networks · Quantitative Biology 2020-07-01 Fuhai Li , Andrew P. Michelson , Randi Foraker , Ming Zhan , Philip R. O. Payne

There remains an urgent need to identify existing drugs that might be suitable for treating patients suffering from COVID-19 infection. Drugs rarely act at a single molecular target, with off target effects often being responsible for…

Biomolecules · Quantitative Biology 2020-09-03 Sakshi Piplani , Puneet Singh , Nikolai Petrovsky , David A. Winkler

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the strain of coronavirus that causes coronavirus disease 2019 (COVID-19), the respiratory illness responsible for the COVID-19 pandemic. Currently there is no known vaccine or…

Biomolecules · Quantitative Biology 2020-06-29 Emilio Angelina , Sebastian Andujar , Oscar Parravicini , Daniel Enriz , Nelida Peruchena

Effective property prediction methods can help accelerate the search for COVID-19 antivirals either through accurate in-silico screens or by effectively guiding on-going at-scale experimental efforts. However, existing prediction tools have…

Quantitative Methods · Quantitative Biology 2020-05-08 Wengong Jin , Regina Barzilay , Tommi Jaakkola

Early detection of COVID-19 is an ongoing area of research that can help with triage, monitoring and general health assessment of potential patients and may reduce operational strain on hospitals that cope with the coronavirus pandemic.…

Machine Learning · Computer Science 2022-01-11 Omid Rohanian , Samaneh Kouchaki , Andrew Soltan , Jenny Yang , Morteza Rohanian , Yang Yang , David Clifton

Researchers worldwide are seeking to repurpose existing drugs or discover new drugs to counter the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A promising source of candidates for such studies is…

Computation and Language · Computer Science 2021-01-13 Zhi Hong , J. Gregory Pauloski , Logan Ward , Kyle Chard , Ben Blaiszik , Ian Foster

Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic in over 200 countries and territories, which has resulted in a great public health concern across the international community. Analysis of X-ray imaging data can play a…

Image and Video Processing · Electrical Eng. & Systems 2021-04-02 Lucy Nwosu , Xiangfang Li , Lijun Qian , Seungchan Kim , Xishuang Dong

Novel coronavirus (COVID-19) outbreak, has raised a calamitous situation all over the world and has become one of the most acute and severe ailments in the past hundred years. The prevalence rate of COVID-19 is rapidly rising every day…

Image and Video Processing · Electrical Eng. & Systems 2022-09-09 Md. Milon Islam , Fakhri Karray , Reda Alhajj , Jia Zeng

Drug repurposing (or repositioning) is the process of finding new therapeutic uses for drugs already approved by drug regulatory authorities (e.g., the Food and Drug Administration (FDA) and Therapeutic Goods Administration (TGA)) for other…

Artificial Intelligence · Computer Science 2023-06-27 Chaarvi Bansal , Rohitash Chandra , Vinti Agarwal , P. R. Deepa

In the past several months, COVID-19 has spread over the globe and caused severe damage to the people and the society. In the context of this severe situation, an effective drug discovery method to generate potential drugs is extremely…

Machine Learning · Computer Science 2021-04-26 Tianyue Cheng , Tianchi Fan , Landi Wang

The COVID-19 (coronavirus) is an ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus was first identified in mid-December 2019 in the Hubei province of Wuhan, China and by now has spread…

Image and Video Processing · Electrical Eng. & Systems 2022-01-26 Aditya Saxena , Shamsheer Pal Singh

The clinical spectrum of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the strain of coronavirus that caused the COVID-19 pandemic, is broad, extending from asymptomatic infection to severe immunopulmonary reactions that, if…

Quantitative Methods · Quantitative Biology 2022-07-18 Aaron Wang , Feng Li , Samantha Chiang , Jennifer Fulcher , Otto Yang , David Wong , Fang Wei

COVID-19, the disease caused by the SARS-CoV-2 virus, has been declared a pandemic by the World Health Organization, which has reported over 18 million confirmed cases as of August 5, 2020. In this review, we present an overview of recent…

Computers and Society · Computer Science 2021-01-12 Joseph Bullock , Alexandra Luccioni , Katherine Hoffmann Pham , Cynthia Sin Nga Lam , Miguel Luengo-Oroz

The COVID-19 pandemic has galvanized the machine learning community to create new solutions that can help in the fight against the virus. The body of literature related to applications of machine learning and artificial intelligence to…

Machine Learning · Computer Science 2021-01-21 Firuz Kamalov , Aswani Cherukuri , Hana Sulieman , Fadi Thabtah , Akbar Hossain

Coronavirus, or COVID-19, is a hazardous disease that has endangered the health of many people around the world by directly affecting the lungs. COVID-19 is a medium-sized, coated virus with a single-stranded RNA, and also has one of the…