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The Image Biomarker Standardisation Initiative (IBSI) aims to improve reproducibility of radiomics studies by standardising the computational process of extracting image biomarkers (features) from images. We have previously established…

Image and Video Processing · Electrical Eng. & Systems 2024-02-08 Adrien Depeursinge , Vincent Andrearczyk , Philip Whybra , Joost van Griethuysen , Henning Müller , Roger Schaer , Martin Vallières , Alex Zwanenburg

The image biomarker standardisation initiative (IBSI) is an independent international collaboration which works towards standardising the extraction of image biomarkers from acquired imaging for the purpose of high-throughput quantitative…

Computer Vision and Pattern Recognition · Computer Science 2020-03-11 Alex Zwanenburg , Stefan Leger , Martin Vallières , Steffen Löck

In this study we investigated the repeatability and reproducibility of radiomic features extracted from MRI images and provide a workflow to identify robust features. 2D and 3D T$_2$-weighted images of a pelvic phantom were acquired on…

Radiomics analysis has emerged as a promising approach for extracting quantitative features from medical images to aid in cancer diagnosis and treatment. However, radiomics research currently lacks standardization, and radiomics features…

Radiomics is a term which refers to the analysis of the large amount of quantitative tumor features extracted from medical images to find useful predictive, diagnostic or prognostic information. Many recent studies have proved that…

Computer Vision and Pattern Recognition · Computer Science 2018-03-14 Hongliu Cao , Simon Bernard , Laurent Heutte , Robert Sabourin

In this study we assessed the repeatability of the values of radiomics features for small prostate tumors using test-retest Multiparametric Magnetic Resonance Imaging (mpMRI) images. The premise of radiomics is that quantitative image…

Computer Vision and Pattern Recognition · Computer Science 2018-11-16 Michael Schwier , Joost van Griethuysen , Mark G Vangel , Steve Pieper , Sharon Peled , Clare M Tempany , Hugo JWL Aerts , Ron Kikinis , Fiona M Fennessy , Andrey Fedorov

Background: The aim of this study was to assess the robustness of cardiac SPECT radiomics features against changes in imaging settings including acquisition and reconstruction settings. Methods: Four scanners were used to acquire SPECT…

Radiomics-based AI models show promise for breast cancer diagnosis but often lack interpretability, limiting clinical adoption. This study addresses the gap between radiomic features (RF) and the standardized BI-RADS lexicon by proposing a…

BACKGROUND: Radiomics provides quantitative features of pulmonary nodules (PNs) which could aid lung cancer diagnosis, but medical image acquisition variability is an obstacle to clinical application. Acquisition effects may differ between…

In high-quality radiotherapy delivery, precise segmentation of targets and healthy structures is essential. This study proposes Radiomics features as a superior measure for assessing the segmentation ability of physicians and…

Image and Video Processing · Electrical Eng. & Systems 2023-11-01 Yoichi Watanabe , Rukhsora Akramova

Radiomics enables quantitative medical image analysis by converting imaging data into structured, high-dimensional feature representations for predictive modeling. Despite methodological developments and encouraging retrospective results,…

Image and Video Processing · Electrical Eng. & Systems 2026-02-03 Fnu Neha , Deepak kumar Shukla

In the context of brain tumor characterization, we focused on two key questions: (a) stability of radiomics features to variability in multiregional segmentation masks obtained with fully-automatic deep segmentation methods and (b)…

Image and Video Processing · Electrical Eng. & Systems 2024-06-12 Maria Nadeem , Asma Shaheen , Muhammad F. A. Chaudhary , Hassan Mohy-ud-Din

Most papers caution against using predictive models for disease stratification based on unselected radiomic features, as these features are affected by contouring variability. Instead, they advocate for the use of the Intraclass Correlation…

We develop and validate a novel spherical radiomics framework for predicting key molecular biomarkers using multiparametric MRI. Conventional Cartesian radiomics extract tumor features on orthogonal grids, which do not fully capture the…

Medical Physics · Physics 2025-10-22 Haotian Feng , Ke Sheng

Background: The high dimensionality of radiomic feature sets, the variability in radiomic feature types and potentially high computational requirements all underscore the need for an effective method to identify the smallest set of…

MR-derived radiomic features have demonstrated substantial predictive utility in modeling different prognostic factors of glioblastomas and other brain cancers. However, the biological relationship underpinning these predictive models has…

Manual delineation of volumes of interest (VOIs) by experts is considered the gold-standard method in radiomics analysis. However, it suffers from inter- and intra-operator variability. A quantitative assessment of the impact of variations…

Image and Video Processing · Electrical Eng. & Systems 2023-09-06 Sepideh Hatamikia , Geevarghese George , Florian Schwarzhans , Amirreza Mahbod , Ramona Woitek

Artificial intelligence (AI) holds strong potential for medical diagnostics, yet its clinical adoption is limited by a lack of interpretability and generalizability. This study introduces the Pathobiological Dictionary for Liver Cancer…

Radiomics-based machine learning models show promise for clinical decision support but are vulnerable to distribution shifts caused by variations in imaging protocols, positioning, and segmentation. This study systematically investigates…

Machine Learning · Computer Science 2025-10-30 Sarmad Ahmad Khan , Simon Bernatz , Zahra Moslehi , Florian Buettner

Objectives: Glioblastomas are the most aggressive brain and central nervous system (CNS) tumors with poor prognosis in adults. The purpose of this study is to develop a machine-learning based classification method using radio-mic features…

Medical Physics · Physics 2019-11-25 Ge Cui , Jiwoong Jeong , Bob Press , Yang Lei , Hui-Kuo Shu , Tian Liu , Walter Curran , Hui Mao , Xiaofeng Yang
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