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Deep learning models designed for visual classification tasks on natural images have become prevalent in medical image analysis. However, medical images differ from typical natural images in many ways, such as significantly higher…

Machine Learning · Computer Science 2019-08-21 Yiqiu Shen , Nan Wu , Jason Phang , Jungkyu Park , Gene Kim , Linda Moy , Kyunghyun Cho , Krzysztof J. Geras

Early cancer detection remains one of the most critical challenges in modern healthcare, where delayed diagnosis significantly reduces survival outcomes. Recent advancements in artificial intelligence, particularly deep learning, have…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Emmanuella Avwerosuoghene Oghenekaro

The opaque nature of deep learning models remains a significant barrier to their clinical adoption in medical imaging. This paper presents a multimodal explainability framework that bridges the gap between convolutional neural network (CNN)…

Computer Vision and Pattern Recognition · Computer Science 2026-05-08 Paul Valery Nguezet , Elie Tagne Fute , Yusuf Brima , Benoit Martin Azanguezet , Marcellin Atemkeng

We present a clustering-based explainability technique for digital pathology models based on convolutional neural networks. Unlike commonly used methods based on saliency maps, such as occlusion, GradCAM, or relevance propagation, which…

Computer Vision and Pattern Recognition · Computer Science 2026-05-28 Adam Bajger , Jan Obdržálek , Vojtěch Kůr , Rudolf Nenutil , Petr Holub , Vít Musil , Tomáš Brázdil

Breast cancer is one of the main causes of death worldwide. Histopathological cellularity assessment of residual tumors in post-surgical tissues is used to analyze a tumor's response to a therapy. Correct cellularity assessment increases…

Image and Video Processing · Electrical Eng. & Systems 2019-09-04 Alexander Rakhlin , Aleksei Tiulpin , Alexey A. Shvets , Alexandr A. Kalinin , Vladimir I. Iglovikov , Sergey Nikolenko

Accurate and reliable histopathological image classification is essential for breast cancer diagnosis. However, many deep learning models remain sensitive to magnification variability and lack interpretability. To address these challenges,…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Enam Ahmed Taufika , Md Ahasanul Arafatha , Abhijit Kumar Ghoshb , Md. Tanzim Rezab , Md Ashad Alamc

Biopsies are the gold standard for breast cancer diagnosis. This task can be improved by the use of Computer Aided Diagnosis (CAD) systems, reducing the time of diagnosis and reducing the inter and intra-observer variability. The advances…

Computer Vision and Pattern Recognition · Computer Science 2019-05-30 Jonathan de Matos , Alceu de S. Britto , Luiz E. S. de Oliveira , Alessandro L. Koerich

Explainable AI (XAI) in medical histopathology is essential for enhancing the interpretability and clinical trustworthiness of deep learning models in cancer diagnosis. However, the black-box nature of these models often limits their…

Image and Video Processing · Electrical Eng. & Systems 2025-05-06 Raktim Kumar Mondol , Ewan K. A. Millar , Peter H. Graham , Lois Browne , Arcot Sowmya , Erik Meijering

In routine colorectal cancer management, histologic samples stained with hematoxylin and eosin are commonly used. Nonetheless, their potential for defining objective biomarkers for patient stratification and treatment selection is still…

Quantitative Methods · Quantitative Biology 2024-09-26 Fabi Prezja , Leevi Annala , Sampsa Kiiskinen , Suvi Lahtinen , Timo Ojala , Pekka Ruusuvuori , Teijo Kuopio

A definitive diagnosis of a brain tumour is essential for enhancing treatment success and patient survival. However, it is difficult to manually evaluate multiple magnetic resonance imaging (MRI) images generated in a clinic. Therefore,…

Neural and Evolutionary Computing · Computer Science 2022-04-27 Amin Abdollahi Dehkordi , Mina Hashemi , Mehdi Neshat , Seyedali Mirjalili , Ali Safaa Sadiq

Deep learning has the potential to revolutionize medical practice by automating and performing important tasks like detecting and delineating the size and locations of cancers in medical images. However, most deep learning models rely on…

Image and Video Processing · Electrical Eng. & Systems 2023-11-28 Eirik A. Østmo , Kristoffer K. Wickstrøm , Keyur Radiya , Michael C. Kampffmeyer , Robert Jenssen

Deep learning, as a promising new area of machine learning, has attracted a rapidly increasing attention in the field of medical imaging. Compared to the conventional machine learning methods, deep learning requires no hand-tuned feature…

Quantitative Methods · Quantitative Biology 2016-11-29 He Yang , Hengyong Yu , Ge Wang

Breast Cancer is a major cause of death worldwide among women. Hematoxylin and Eosin (H&E) stained breast tissue samples from biopsies are observed under microscopes for the primary diagnosis of breast cancer. In this paper, we propose a…

Computer Vision and Pattern Recognition · Computer Science 2018-07-26 Aditya Golatkar , Deepak Anand , Amit Sethi

Medical imaging is an essential tool in many areas of medical applications, used for both diagnosis and treatment. However, reading medical images and making diagnosis or treatment recommendations require specially trained medical…

Computer Vision and Pattern Recognition · Computer Science 2019-03-13 Wentao Zhu

Efficient and precise classification of histological cell nuclei is of utmost importance due to its potential applications in the field of medical image analysis. It would facilitate the medical practitioners to better understand and…

Computer Vision and Pattern Recognition · Computer Science 2019-11-19 S H Shabbeer Basha , Soumen Ghosh , Kancharagunta Kishan Babu , Shiv Ram Dubey , Viswanath Pulabaigari , Snehasis Mukherjee

Convolutional neural networks (CNNs) define the current state-of-the-art for image recognition. With their emerging popularity, especially for critical applications like medical image analysis or self-driving cars, confirmability is…

Computer Vision and Pattern Recognition · Computer Science 2018-01-08 Keyang Zhou , Bernhard Kainz

Cancer diagnosis, prognosis, and therapeutic response prediction are heavily influenced by the relationship between the histopathological structures and the function of the tissue. Recent approaches acknowledging the structure-function…

Histopathology is a reflection of the molecular changes and provides prognostic phenotypes representing the disease progression. In this study, we introduced feature scores generated from hematoxylin and eosin histology images based on deep…

Quantitative Methods · Quantitative Biology 2020-07-28 Okyaz Eminaga , Mahmood Abbas , Yuri Tolkach , Rosalie Nolley , Christian Kunder , Axel Semjonow , Martin Boegemann

Convolutional Neural Networks have shown promising effectiveness in identifying different types of cancer from radiographs. However, the opaque nature of CNNs makes it difficult to fully understand the way they operate, limiting their…

Image and Video Processing · Electrical Eng. & Systems 2026-03-16 Michael Okonoda , Eder Martinez , Abhilekha Dalal , Lior Shamir

Automated classification of histopathological whole-slide images (WSI) of breast tissue requires analysis at very high resolutions with a large contextual area. In this paper, we present context-aware stacked convolutional neural networks…

Computer Vision and Pattern Recognition · Computer Science 2017-05-11 Babak Ehteshami Bejnordi , Guido Zuidhof , Maschenka Balkenhol , Meyke Hermsen , Peter Bult , Bram van Ginneken , Nico Karssemeijer , Geert Litjens , Jeroen van der Laak