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Advances in single-cell sequencing have enabled high-resolution profiling of diverse molecular modalities, while integrating unpaired multi-omics single-cell data remains challenging. Existing approaches either rely on pair information or…

Quantitative Methods · Quantitative Biology 2026-01-21 Jianle Sun , Chaoqi Liang , Ran Wei , Peng Zheng , Lei Bai , Wanli Ouyang , Hongliang Yan , Peng Ye

Distance metric learning (DML) approaches learn a transformation to a representation space where distance is in correspondence with a predefined notion of similarity. While such models offer a number of compelling benefits, it has been…

Machine Learning · Statistics 2016-03-03 Oren Rippel , Manohar Paluri , Piotr Dollar , Lubomir Bourdev

Deep Metric Learning (DML) provides a crucial tool for visual similarity and zero-shot applications by learning generalizing embedding spaces, although recent work in DML has shown strong performance saturation across training objectives.…

Computer Vision and Pattern Recognition · Computer Science 2021-06-08 Karsten Roth , Timo Milbich , Björn Ommer , Joseph Paul Cohen , Marzyeh Ghassemi

Multimodal Large Language Models (MLLMs) have demonstrated strong cross-modal reasoning capabilities, yet their potential for vision-only tasks remains underexplored. We investigate MLLMs as training-free similarity estimators for…

Computer Vision and Pattern Recognition · Computer Science 2026-04-16 Bahey Tharwat , Giorgos Kordopatis-Zilos , Pavel Suma , Ian Reid , Giorgos Tolias

In this paper, we propose SimMLM, a simple yet powerful framework for multimodal learning with missing modalities. Unlike existing approaches that rely on sophisticated network architectures or complex data imputation techniques, SimMLM…

Computer Vision and Pattern Recognition · Computer Science 2025-08-07 Sijie Li , Chen Chen , Jungong Han

Large Language Models (LLMs), benefiting from the auto-regressive modelling approach performed on massive unannotated texts corpora, demonstrates powerful perceptual and reasoning capabilities. However, as for extending auto-regressive…

Computer Vision and Pattern Recognition · Computer Science 2024-09-24 Tianshuo Peng , Zuchao Li , Lefei Zhang , Hai Zhao , Ping Wang , Bo Du

This paper explores the intersection of Discrete Choice Modeling (DCM) and machine learning, focusing on the integration of image data into DCM's utility functions and its impact on model interpretability. We investigate the consequences of…

Computer Vision and Pattern Recognition · Computer Science 2023-12-25 Brian Sifringer , Alexandre Alahi

Dictionary leaning (DL) and dimensionality reduction (DR) are powerful tools to analyze high-dimensional noisy signals. This paper presents a proposal of a novel Riemannian joint dimensionality reduction and dictionary learning (R-JDRDL) on…

Computer Vision and Pattern Recognition · Computer Science 2019-02-13 Hiroyuki Kasai , Bamdev Mishra

Large language models (LLMs) have become an important semantic infrastructure for modern recommender systems. A prevailing paradigm integrates LLM-derived semantic embeddings with collaborative representations via representation alignment,…

Information Retrieval · Computer Science 2026-04-27 Maolin Wang , Dongze Wu , Jianing Zhou , Hongyu Chen , Beining Bao , Yu Jiang , Chenbin Zhang , Chang Wang , Jian Liu , Lei Sha

Multimodal representation learning has been largely driven by contrastive models such as CLIP, which learn a shared embedding space by aligning paired image-text samples. While effective for general-purpose representation learning, such…

Machine Learning · Computer Science 2026-05-12 Yang Qiao , Yuntong Hu , Bowen Zhu , Hasibul Haque , Liang Zhao

Molecular property prediction constitutes a cornerstone of drug discovery and materials science, necessitating models capable of disentangling complex structure-property relationships across diverse molecular modalities. Existing approaches…

Machine Learning · Computer Science 2026-03-24 Long Xu , Junping Guo , Jianbo Zhao , Jianbo Lu , Yuzhong Peng

Magnetic Resonance Imaging (MRI) represents an important diagnostic modality; however, its inherently slow acquisition process poses challenges in obtaining fully-sampled $k$-space data under motion. In the absence of fully-sampled…

Image and Video Processing · Electrical Eng. & Systems 2024-12-23 George Yiasemis , Nikita Moriakov , Clara I. Sánchez , Jan-Jakob Sonke , Jonas Teuwen

Recent advances in large language models (LLMs) and biomedical foundation models (BioFMs) have achieved strong results in biological text reasoning, molecular modeling, and single-cell analysis, yet they remain siloed in disjoint embedding…

Quantitative Methods · Quantitative Biology 2025-10-03 Ching-Huei Tsou , Michal Ozery-Flato , Ella Barkan , Diwakar Mahajan , Ben Shapira

The discovery of causal relationships from high-dimensional data is a major open problem in bioinformatics. Machine learning and feature attribution models have shown great promise in this context but lack causal interpretation. Here, we…

Machine Learning · Computer Science 2023-04-26 Payam Dibaeinia , Saurabh Sinha

Machine learning (ML) models have significantly impacted various domains in our everyday lives. While large language models (LLMs) offer intuitive interfaces and versatility, task-specific ML models remain valuable for their efficiency and…

Human-Computer Interaction · Computer Science 2024-12-04 Wataru Kawabe , Yusuke Sugano

Cross-modal retrieval between food images and recipe texts is an important task with applications in nutritional management, dietary logging, and cooking assistance. Existing methods predominantly rely on dual-encoder architectures with…

Computer Vision and Pattern Recognition · Computer Science 2026-04-20 Keisuke Gomi , Keiji Yanai

Current multilingual vision-language models either require a large number of additional parameters for each supported language, or suffer performance degradation as languages are added. In this paper, we propose a Scalable Multilingual…

Computer Vision and Pattern Recognition · Computer Science 2020-08-31 Andrea Burns , Donghyun Kim , Derry Wijaya , Kate Saenko , Bryan A. Plummer

Vision-Language Models (VLMs) excel at understanding single images, aided by high-quality instruction datasets. However, multi-image reasoning remains underexplored in the open-source community due to two key challenges: (1) scaling…

Computer Vision and Pattern Recognition · Computer Science 2025-02-18 Andrew Li , Rahul Thapa , Rahul Chalamala , Qingyang Wu , Kezhen Chen , James Zou

This paper demonstrates that spatial information can be used to learn interpretable representations in medical images using Self-Supervised Learning (SSL). Our proposed method, ISImed, is based on the observation that medical images exhibit…

Computer Vision and Pattern Recognition · Computer Science 2024-10-23 Nabil Jabareen , Dongsheng Yuan , Sören Lukassen

Supervised Machine Learning (SML) algorithms, such as Gradient Boosting, Random Forest, and Neural Networks, have become popular in recent years due to their superior predictive performance over traditional statistical methods. However,…

Machine Learning · Statistics 2020-07-30 Linwei Hu , Jie Chen , Vijayan N. Nair , Agus Sudjianto
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