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Zeroth-order optimization (ZO) has been a powerful framework for solving black-box problems, which estimates gradients using zeroth-order data to update variables iteratively. The practical applicability of ZO critically depends on the…

Optimization and Control · Mathematics 2026-03-03 Ruiyang Jin , Yuke Zhou , Yujie Tang , Jie Song , Siyang Gao

Molecule optimization is an important problem in chemical discovery and has been approached using many techniques, including generative modeling, reinforcement learning, genetic algorithms, and much more. Recent work has also applied…

Biomolecules · Quantitative Biology 2022-10-31 Elvin Lo , Pin-Yu Chen

Zeroth-order (ZO) optimization provides a gradient-free alternative to first-order (FO) methods by estimating gradients via finite differences of function evaluations, and has recently emerged as a memory-efficient paradigm for fine-tuning…

Machine Learning · Computer Science 2026-02-24 Yicheng Lang , Changsheng Wang , Yihua Zhang , Mingyi Hong , Zheng Zhang , Wotao Yin , Sijia Liu

Zeroth-order (ZO) optimization, learning from finite differences of function evaluations without backpropagation, has recently regained attention in deep learning due to its memory efficiency and applicability to gray- or black-box…

Zeroth-order (ZO) optimization has become a popular technique for solving machine learning (ML) problems when first-order (FO) information is difficult or impossible to obtain. However, the scalability of ZO optimization remains an open…

We consider the problem of minimizing a high-dimensional objective function, which may include a regularization term, using (possibly noisy) evaluations of the function. Such optimization is also called derivative-free, zeroth-order, or…

Optimization and Control · Mathematics 2023-03-20 HanQin Cai , Daniel Mckenzie , Wotao Yin , Zhenliang Zhang

In this work, we focus on the study of stochastic zeroth-order (ZO) optimization which does not require first-order gradient information and uses only function evaluations. The problem of ZO optimization has emerged in many recent machine…

Machine Learning · Statistics 2020-12-22 Pranay Sharma , Kaidi Xu , Sijia Liu , Pin-Yu Chen , Xue Lin , Pramod K. Varshney

Zeroth-order (ZO) optimization is popular in real-world applications that accessing the gradient information is expensive or unavailable. Recently, adaptive ZO methods that normalize gradient estimators by the empirical standard deviation…

Optimization and Control · Mathematics 2026-02-03 Haishan Ye , Luo Luo

Zeroth-order (ZO) optimization has long been favored for its biological plausibility and its capacity to handle non-differentiable objectives, yet its computational complexity has historically limited its application in deep neural…

Machine Learning · Computer Science 2026-02-12 Sansheng Cao , Zhengyu Ma , Yonghong Tian

Zeroth-order (ZO) optimization is one key technique for machine learning problems where gradient calculation is expensive or impossible. Several variance reduced ZO proximal algorithms have been proposed to speed up ZO optimization for…

Optimization and Control · Mathematics 2024-10-04 Bin Gu , Xiyuan Wei , Hualin Zhang , Yi Chang , Heng Huang

Zeroth-order (ZO) optimization with ordinal feedback has emerged as a fundamental problem in modern machine learning systems, particularly in human-in-the-loop settings such as reinforcement learning from human feedback, preference…

Optimization and Control · Mathematics 2025-12-23 Haishan Ye

Zeroth-order optimization (ZOO) is an important framework for stochastic optimization when gradients are unavailable or expensive to compute. A potential limitation of existing ZOO methods is the bias inherent in most gradient estimators…

Machine Learning · Computer Science 2025-10-24 Shaocong Ma , Heng Huang

Zeroth-Order (ZO) optimization has emerged as a promising solution for fine-tuning LLMs under strict memory constraints, as it avoids the prohibitive memory cost of storing activations for backpropagation. However, existing ZO methods…

Machine Learning · Computer Science 2026-05-25 Wei Lin , Yining Jiang , Qingyu Song , Qiao Xiang , Hong Xu

Zeroth-order (ZO) optimization enables memory-efficient training of neural networks by estimating gradients via forward passes only, eliminating the need for backpropagation. However, the stochastic nature of gradient estimation…

Machine Learning · Computer Science 2026-03-24 Chen Zhang , Yuxin Cheng , Chenchen Ding , Shuqi Wang , Jingreng Lei , Runsheng Yu , Yik-Chung WU , Ngai Wong

Fine-tuning Large Language Models (LLMs) has proven effective for a variety of downstream tasks. However, as LLMs grow in size, the memory demands for backpropagation become increasingly prohibitive. Zeroth-order (ZO) optimization methods…

Machine Learning · Computer Science 2025-07-25 Ziming Yu , Pan Zhou , Sike Wang , Jia Li , Mi Tian , Hua Huang

Zeroth-order optimizers have recently emerged as a practical approach for fine-tuning large language models (LLMs), significantly reducing GPU memory consumption compared to traditional first-order methods. Yet, existing zeroth-order…

Machine Learning · Computer Science 2025-10-02 Kairun Zhang , Haoyu Li , Yanjun Zhao , Yifan Sun , Huan Zhang

As application demands for zeroth-order (gradient-free) optimization accelerate, the need for variance reduced and faster converging approaches is also intensifying. This paper addresses these challenges by presenting: a) a comprehensive…

Machine Learning · Computer Science 2018-06-08 Sijia Liu , Bhavya Kailkhura , Pin-Yu Chen , Paishun Ting , Shiyu Chang , Lisa Amini

$\ell_0$ constrained optimization is prevalent in machine learning, particularly for high-dimensional problems, because it is a fundamental approach to achieve sparse learning. Hard-thresholding gradient descent is a dominant technique to…

Machine Learning · Computer Science 2024-03-19 William de Vazelhes , Hualin Zhang , Huimin Wu , Xiao-Tong Yuan , Bin Gu

Large language models have demonstrated exceptional capabilities across diverse tasks, but their fine-tuning demands significant memory, posing challenges for resource-constrained environments. Zeroth-order (ZO) optimization provides a…

Machine Learning · Computer Science 2025-02-18 Zhen Zhang , Yifan Yang , Kai Zhen , Nathan Susanj , Athanasios Mouchtaris , Siegfried Kunzmann , Zheng Zhang

Zeroth-order optimization addresses problems where gradient information is inaccessible or impractical to compute. While most existing methods rely on first-order approximations, incorporating second-order (curvature) information can, in…

Machine Learning · Computer Science 2025-07-09 Dongyoon Kim , Sungjae Lee , Wonjin Lee , Kwang In Kim
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