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We demonstrate the application of mixture density networks (MDNs) in the context of automated radiation therapy treatment planning. It is shown that an MDN can produce good predictions of dose distributions as well as reflect uncertain…

Medical Physics · Physics 2021-07-06 Viktor Nilsson , Hanna Gruselius , Tianfang Zhang , Geert De Kerf , Michaël Claessens

Proton computed tomography (pCT) is a novel medical imaging modality for mapping the distribution of proton relative stopping power (RSP) in medical objects of interest. Compared to conventional X-ray computed tomography, where range…

The need to recognise long-term dependencies in sequential data such as video streams has made Long Short-Term Memory (LSTM) networks a prominent Artificial Intelligence model for many emerging applications. However, the high computational…

Signal Processing · Electrical Eng. & Systems 2019-10-31 Alexandros Kouris , Stylianos I. Venieris , Michail Rizakis , Christos-Savvas Bouganis

Objective. Proton beams enable localized dose delivery. Accurate range estimation is essential, but planning still relies on X-ray CT, which introduces uncertainty in stopping power and range. Proton CT measures water equivalent thickness…

Medical Physics · Physics 2025-09-15 Atiq Ur Rahman , Chun-Chieh Wang , Shu-Wei Wu , Tsi-Chian Chao , I-Chun Cho

The use of low numerical precision is a fundamental optimization included in modern accelerators for Deep Neural Networks (DNNs). The number of bits of the numerical representation is set to the minimum precision that is able to retain…

Signal Processing · Electrical Eng. & Systems 2019-11-12 Franyell Silfa , Jose-Maria Arnau , Antonio Gonzàlez

Purpose: To demonstrate a proton imaging system based on well-established fast scintillator technology to achieve high performance with low cost and complexity, with the potential of a straightforward translation into clinical use. Methods:…

The purpose of this study is to determine whether organ sparing and target coverage can be simultaneously maintained for pencil beam scanning (PBS) proton therapy treatment of thoracic tumors in the presence of motion, stopping power…

Purpose: Intensity-modulated proton therapy (IMPT) offers precise tumor coverage while sparing organs at risk (OARs) in head and neck (H&N) cancer. However, its sensitivity to anatomical changes requires frequent adaptation through online…

This study develops and validates a patient-specific Monte Carlo (MC) dosimetry framework for propagation-based phase-contrast breast CT (BCT) at the Imaging and Medical Beamline (IMBL), ANSTO Australian Synchrotron, for accurate mean…

Diagnosis of cardiovascular diseases usually relies on the widely used standard 12-Lead (S12) ECG system. However, such a system could be bulky, too resource-intensive, and too specialized for personalized home-based monitoring. In…

Signal Processing · Electrical Eng. & Systems 2023-08-15 Rahul LR , Albert Shaiju , Soumya Jana

Long Short-Term Memory (LSTM) is a prominent recurrent neural network for extracting dependencies from sequential data such as time-series and multi-view data, having achieved impressive results for different visual recognition tasks. A…

Computer Vision and Pattern Recognition · Computer Science 2020-06-03 Alireza Sepas-Moghaddam , Ali Etemad , Fernando Pereira , Paulo Lobato Correia

With the advancement of treatment modalities in radiation therapy for cancer patients, outcomes have improved, but at the cost of increased treatment plan complexity and planning time. The accurate prediction of dose distributions would…

Medical Physics · Physics 2018-12-03 Dan Nguyen , Troy Long , Xun Jia , Weiguo Lu , Xuejun Gu , Zohaib Iqbal , Steve Jiang

Monte Carlo (MC) simulations provide gold-standard accuracy for carbon ion therapy dose calculations but are computationally intensive. Analytical pencil beam algorithms offer speed but reduced accuracy in heterogeneous tissues. We…

The Long Short-Term Memory (LSTM) layer is an important advancement in the field of neural networks and machine learning, allowing for effective training and impressive inference performance. LSTM-based neural networks have been…

Neural and Evolutionary Computing · Computer Science 2019-01-04 Daniel Kent , Fathi M. Salem

We compute, from first principles, the absolute dose or fluence distribution per incident proton charge in a known heterogeneous terrain exposed to known proton beams. The algorithm is equally amenable to scattered or scanned beams. All…

Medical Physics · Physics 2016-10-05 Bernard Gottschalk

The distribution of absorbed dose in radionuclide therapy with Lu$^{177}$ can be approximated by convolving an image of the time-integrated activity distribution with a dose voxel kernel representing different tissue types. This fast but…

Machine Learning · Statistics 2026-03-25 Luciano Melodia

Recurrent Neural Networks and in particular Long Short-Term Memory (LSTM) networks have demonstrated state-of-the-art accuracy in several emerging Artificial Intelligence tasks. However, the models are becoming increasingly demanding in…

Computer Vision and Pattern Recognition · Computer Science 2018-01-10 Michalis Rizakis , Stylianos I. Venieris , Alexandros Kouris , Christos-Savvas Bouganis

Recurrent neural networks (RNNs) have led to breakthroughs in natural language processing and speech recognition, wherein hundreds of millions of people use such tools on a daily basis through smartphones, email servers and other avenues.…

Disordered Systems and Neural Networks · Physics 2020-12-02 Sun-Ting Tsai , En-Jui Kuo , Pratyush Tiwary

Verification of patient specific proton stopping powers obtained in the patient treatment position can be used to reduce the distal margins needed in particle beam planning. Proton radiography can be used as a pre-treatment instrument to…

Travel time tomography for the velocity structure of a medium is a highly non-linear and non-unique inverse problem. Monte Carlo methods are becoming increasingly common choices to provide probabilistic solutions to tomographic problems but…

Computational Physics · Physics 2020-05-08 Stephanie Earp , Andrew Curtis
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