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Modeling and drawing inference on the joint associations between single nucleotide polymorphisms and a disease has sparked interest in genome-wide associations studies. In the motivating Boston Lung Cancer Survival Cohort (BLCSC) data, the…

Methodology · Statistics 2021-11-18 Lu Xia , Bin Nan , Yi Li

In regression problems where there is no known true underlying model, conformal prediction methods enable prediction intervals to be constructed without any assumptions on the distribution of the underlying data, except that the training…

Methodology · Statistics 2023-01-31 Wenyu Chen , Kelli-Jean Chun , Rina Foygel Barber

This paper presents an algorithm for the preprocessing of observation data aimed at improving the robustness of orbit determination tools. Two objectives are fulfilled: obtain a refined solution to the initial orbit determination problem…

Numerical Analysis · Mathematics 2023-11-07 Alberto Fossà , Roberto Armellin , Emmanuel Delande , Matteo Losacco , Francesco Sanfedino

We consider the estimation of average treatment effects in observational studies and propose a new framework of robust causal inference with unobserved confounders. Our approach is based on distributionally robust optimization and proceeds…

Methodology · Statistics 2023-02-06 Dimitris Bertsimas , Kosuke Imai , Michael Lingzhi Li

We suggest how to construct joint confidence distributions for several parameters and apply these ideas to an autoregressive process of general order. The implied non informative prior for the parameters, i.e. the ratio between the…

Methodology · Statistics 2025-03-11 Rolf Larsson

Instrumental variable (IV) and proximal causal learning (Proxy) methods are central frameworks for causal inference in the presence of unobserved confounding. Despite substantial methodological advances, existing approaches rarely provide…

Machine Learning · Statistics 2026-03-03 Yuqi Zhang , Krikamol Muandet , Dino Sejdinovic , Edwin Fong , Siu Lun Chau

This work presents a novel simulation-based approach for constructing confidence regions in parametric models, which is particularly suited for generative models and situations where limited data and conventional asymptotic approximations…

Methodology · Statistics 2026-01-22 Elena Bortolato , Laura Ventura

The problem we concentrate on is as follows: given (1) a convex compact set $X$ in ${\mathbb{R}}^n$, an affine mapping $x\mapsto A(x)$, a parametric family $\{p_{\mu}(\cdot)\}$ of probability densities and (2) $N$ i.i.d. observations of the…

Statistics Theory · Mathematics 2009-08-24 Anatoli B. Juditsky , Arkadi S. Nemirovski

We study the problem of using i.i.d. samples from an unknown multivariate probability distribution $p$ to estimate the mutual information of $p$. This problem has recently received attention in two settings: (1) where $p$ is assumed to be…

Statistics Theory · Mathematics 2017-02-28 Shashank Singh , Barnabás Pøczos

This paper studies the problem of {\em learning} the probability distribution $P_X$ of a discrete random variable $X$ using indirect and sequential samples. At each time step, we choose one of the possible $K$ functions, $g_1, \ldots, g_K$…

Machine Learning · Computer Science 2018-08-17 Samarth Gupta , Gauri Joshi , Osman Yağan

The density deconvolution problem involves recovering a target density g from a sample that has been corrupted by noise. From the perspective of Le Cam's local asymptotic normality theory, we show that non-parametric density deconvolution…

Statistics Theory · Mathematics 2015-07-06 Stefan Wager

This paper develops inferential methods for a very general class of ill-posed models in econometrics encompassing the nonparametric instrumental variable regression, various functional regressions, and the density deconvolution. We focus on…

Statistics Theory · Mathematics 2020-12-22 Andrii Babii

The high energy physics unfolding problem is an important statistical inverse problem in data analysis at the Large Hadron Collider (LHC) at CERN. The goal of unfolding is to make nonparametric inferences about a particle spectrum from…

Applications · Statistics 2017-06-09 Mikael Kuusela , Philip B. Stark

Consider the observation of n iid realizations of an experiment with d>1 possible outcomes, which corresponds to a single observation of a multinomial distribution M(n,p) where p is an unknown discrete distribution on {1,...,d}. In many…

Computation · Statistics 2010-06-15 Djalil Chafai , Didier Concordet

From a systems biology perspective the majority of cancer models, although interesting and providing a qualitative explanation of some problems, have a major disadvantage in that they usually miss a genuine connection with experimental…

Statistics Theory · Mathematics 2023-05-25 Zuzanna Szymańska , Jakub Skrzeczkowski , Błażej Miasojedow , Piotr Gwiazda

We consider drawing statistical inferences based on data subject to non-Gaussian measurement error. Unlike most existing methods developed under the assumption of Gaussian measurement error, the proposed strategy exploits hypercomplex…

Methodology · Statistics 2025-05-06 Nicholas W. Woolsey , Xianzheng Huang

We provide a selected overview of methodology and theory for estimation and inference on the edge weights in high-dimensional directed and undirected Gaussian graphical models. For undirected graphical models, two main explicit…

Statistics Theory · Mathematics 2018-01-26 Jana Jankova , Sara van de Geer

Many applications of classification methods not only require high accuracy but also reliable estimation of predictive uncertainty. However, while many current classification frameworks, in particular deep neural networks, achieve high…

Machine Learning · Computer Science 2020-02-28 Jonathan Wenger , Hedvig Kjellström , Rudolph Triebel

We propose employing a high-dimensional generalized method of moments (GMM) estimator, regularized for dimension reduction and subsequently debiased to correct for shrinkage bias (referred to as a debiased-regularized estimator), for…

Econometrics · Economics 2025-07-03 Victor Chernozhukov , Chen Huang , Weining Wang

This paper revisits a fundamental problem in statistical inference from a non-asymptotic theoretical viewpoint $\unicode{x2013}$ the construction of confidence sets. We establish a finite-sample bound for the estimator, characterizing its…

Statistics Theory · Mathematics 2023-01-03 Lang Liu , Zaid Harchaoui
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