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This study systematically compared data-driven and model-based strategies for metabolite quantification in magnetic resonance spectroscopy (MRS), focusing on resilience to out-of-distribution (OoD) effects and the balance between accuracy,…

Signal Processing · Electrical Eng. & Systems 2025-12-01 Julian P. Merkofer , Antonia Kaiser , Anouk Schrantee , Oliver J. Gurney-Champion , Ruud J. G. van Sloun

In preclinical investigations, e.g. in in vitro, in vivo and in silico studies, the pharmacokinetic, pharmacodynamic and toxicological characteristics of a drug are evaluated before advancing to first-in-man trial. Usually, each study is…

Data assimilation (DA) is integrated with machine learning in order to perform entirely data-driven online state estimation. To achieve this, recurrent neural networks (RNNs) are implemented as surrogate models to replace key components of…

In recent years, deep learning (DL) techniques have provided state-of-the-art performance on different medical imaging tasks. However, the availability of good quality annotated medical data is very challenging due to involved time…

Machine Learning · Computer Science 2020-12-29 Muhammad Ahtazaz Ahsan , Adnan Qayyum , Junaid Qadir , Adeel Razi

Owe to the recent advancements in Artificial Intelligence especially deep learning, many data-driven decision support systems have been implemented to facilitate medical doctors in delivering personalized care. We focus on the deep…

Machine Learning · Computer Science 2019-07-24 Siqi Liu , Kee Yuan Ngiam , Mengling Feng

Reinforcement learning (RL) is an important field of research in machine learning that is increasingly being applied to complex optimization problems in physics. In parallel, concepts from physics have contributed to important advances in…

Machine Learning · Computer Science 2023-05-11 Argenis Arriojas , Jacob Adamczyk , Stas Tiomkin , Rahul V. Kulkarni

Conventional radiotherapy dose calculation algorithms are often computationally slow and non-differentiable, creating bottlenecks for online adaptive radiotherapy (ART) and limiting end-to-end automatic planning. Deep learning provides…

People with type 1 diabetes (T1D) lack the ability to produce the insulin their bodies need. As a result, they must continually make decisions about how much insulin to self-administer to adequately control their blood glucose levels.…

Machine Learning · Computer Science 2020-09-22 Ian Fox , Joyce Lee , Rodica Pop-Busui , Jenna Wiens

Optimal decision making with limited or no information in stochastic environments where multiple agents interact is a challenging topic in the realm of artificial intelligence. Reinforcement learning (RL) is a popular approach for arriving…

Machine Learning · Computer Science 2019-01-08 Roi Ceren

To overcome the curses of dimensionality and modeling of Dynamic Programming (DP) methods to solve Markov Decision Process (MDP) problems, Reinforcement Learning (RL) methods are adopted in practice. Contrary to traditional RL algorithms…

Machine Learning · Computer Science 2021-08-24 Arghyadip Roy , Vivek Borkar , Abhay Karandikar , Prasanna Chaporkar

This paper considers the problem of multi-target detection for massive multiple input multiple output (MMIMO) cognitive radar (CR). The concept of CR is based on the perception-action cycle that senses and intelligently adapts to the…

Signal Processing · Electrical Eng. & Systems 2021-03-03 Aya Mostafa Ahmed , Alaa Alameer Ahmad , Stefano Fortunati , Aydin Sezgin , Maria S. Greco , Fulvio Gini

Respondent-driven sampling (RDS) is widely used to study hidden or hard-to-reach populations by incentivizing study participants to recruit their social connections. The success and efficiency of RDS can depend critically on the nature of…

Methodology · Statistics 2025-01-06 Justin Weltz , Angela Yoon , Yichi Zhang , Alexander Volfovsky , Eric Laber

At the boundary between the known and the unknown, an agent inevitably confronts the dilemma of whether to explore or to exploit. Epistemic uncertainty reflects such boundaries, representing systematic uncertainty due to limited knowledge.…

Machine Learning · Computer Science 2026-03-03 Jianfei Ma , Wee Sun Lee

Embodied agents, such as robots and virtual characters, must continuously select actions to execute tasks effectively, solving complex sequential decision-making problems. Given the difficulty of designing such controllers manually,…

Robotics · Computer Science 2026-05-18 Pedro Santana

Phase I oncology trials aim to identify a safe dose - often the maximum tolerated dose (MTD) - for subsequent studies. Conventional designs focus on population-level toxicity modeling, with recent attention on leveraging pharmacokinetic…

Applications · Statistics 2026-01-13 Kyong Ju Lee , Yuan Ji

Modern neural networks have proven to be powerful function approximators, providing state-of-the-art performance in a multitude of applications. They however fall short in their ability to quantify confidence in their predictions - this is…

Machine Learning · Statistics 2020-06-29 Alex J. Chan , Ahmed M. Alaa , Zhaozhi Qian , Mihaela van der Schaar

Triplet loss, one of the deep metric learning (DML) methods, is to learn the embeddings where examples from the same class are closer than examples from different classes. Motivated by DML, we propose an effective BP-Triplet Loss for…

Computer Vision and Pattern Recognition · Computer Science 2022-02-22 Shanshan Wang , Lei Zhang , Pichao Wang

Deep learning-based diagnostic performance increases with more annotated data, but large-scale manual annotations are expensive and labour-intensive. Experts evaluate diagnostic images during clinical routine, and write their findings in…

Image and Video Processing · Electrical Eng. & Systems 2024-07-01 Joeran S. Bosma , Anindo Saha , Matin Hosseinzadeh , Ilse Slootweg , Maarten de Rooij , Henkjan Huisman

Typical reinforcement learning (RL) methods show limited applicability for real-world industrial control problems because industrial systems involve various constraints and simultaneously require continuous and discrete control. To overcome…

Artificial Intelligence · Computer Science 2021-05-20 Hyungjun Park , Daiki Min , Jong-hyun Ryu , Dong Gu Choi

This work considers the problem of personalized dose guidance using Bayesian optimization that learns the optimum drug dose tailored to each individual, thus improving therapeutic outcomes. Safe learning using interior point method ensures…

Optimization and Control · Mathematics 2022-11-01 Dinesh Krishnamoorthy , Francis J. Doyle
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