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COVID-19 has been a public health emergency of international concern since early 2020. Reliable forecasting is critical to diminish the impact of this disease. To date, a large number of different forecasting models have been proposed,…

Machine Learning · Computer Science 2021-10-04 Yun Zhao , Yuqing Wang , Junfeng Liu , Haotian Xia , Zhenni Xu , Qinghang Hong , Zhiyang Zhou , Linda Petzold

This paper deals with the problem of estimating variables in nonlinear models for the spread of disease and its application to the COVID-19 epidemic. First unconstrained methods are revisited and they are shown to correspond to the…

Optimization and Control · Mathematics 2020-08-20 Mauricio C. de Oliveira

Forecasts of hospitalisations of infectious diseases play an important role for allocating healthcare resources during epidemics and pandemics. Large-scale analysis of model forecasts during the COVID-19 pandemic has shown that the model…

Populations and Evolution · Quantitative Biology 2025-05-20 Grégoire Béchade , Torbjörn Lundh , Philip Gerlee

Uncertainty quantification is essential in decision-making, especially when joint distributions of random variables are involved. While conformal prediction provides distribution-free prediction sets with valid coverage guarantees, it…

Machine Learning · Computer Science 2025-01-03 Rui Luo , Zhixin Zhou

The US COVID-19 Forecast Hub, a repository of COVID-19 forecasts from over 50 independent research groups, is used by the Centers for Disease Control and Prevention (CDC) for their official COVID-19 communications. As such, the Forecast Hub…

Applications · Statistics 2025-02-20 Saad Mohammad Abrar , Naman Awasthi , Daniel Smolyak , Vanessa Frias-Martinez

Predicting the endemic/epidemic transition during the temporal evolution of a contagious disease. Methods: Defining indicators for detecting the transition endemic/epidemic, with four scalars to be compared, calculated from the daily…

Analysis of PDEs · Mathematics 2023-10-02 Jacques Demongeot , Pierre Magal , Kayode Oshnubi

Hospitalisations from COVID-19 with Omicron sub-lineages have put a sustained pressure on the English healthcare system. Understanding the expected healthcare demand enables more effective and timely planning from public health. We collect…

Forecasting has become a natural benchmark for reasoning under uncertainty. Yet existing evaluations of large language models remain limited to judgmental tasks in simple formats, such as binary or multiple-choice questions. In practice,…

Machine Learning · Computer Science 2026-04-20 Jeremy Qin , Maksym Andriushchenko

Pandemic control measures like lock-down, restrictions on restaurants and gatherings, social-distancing have shown to be effective in curtailing the spread of COVID-19. However, their sustained enforcement has negative economic effects. To…

The continuously growing number of COVID-19 cases pressures healthcare services worldwide. Accurate short-term forecasting is thus vital to support country-level policy making. The strategies adopted by countries to combat the pandemic…

Methodology · Statistics 2021-04-07 Thiago de Paula Oliveira , Rafael de Andrade Moral

With the outbreak of the COVID-19 pandemic, various studies have focused on predicting the trajectory and risk factors of the virus and its variants. Building on previous work that addressed this problem using genetic and epidemiological…

Applications · Statistics 2023-12-25 Catherine Li , Daniel Lazarev

Modeling the spread of COVID-19 is crucial for informing public health policy. All models for COVID-19 epidemiology rely on parameters describing the dynamics of the infection process. The meanings of epidemiological parameters like R_0,…

Other Quantitative Biology · Quantitative Biology 2020-07-13 Yinon M. Bar-On , Ron Sender , Avi I. Flamholz , Rob Phillips , Ron Milo

The ongoing COVID-19 pandemic calls for a multi-faceted public health response comprising complementary interventions to control the spread of the disease while vaccines and therapies are developed. Many of these interventions need to be…

Applications · Statistics 2020-08-24 Andres Colubri , Kailash Yadav , Abhishek Jha , Pardis C. Sabeti

The advent of the COVID-19 pandemic has instigated unprecedented changes in many countries around the globe, putting a significant burden on the health sectors, affecting the macro economic conditions, and altering social interactions…

Physics and Society · Physics 2020-07-23 Dmitry Gordeev , Philipp Singer , Marios Michailidis , Mathias Müller , SriSatish Ambati

Time-to-event forecasts are essential when decisions depend on event timing. This article develops a framework for evaluating such forecasts when the event has not yet occurred or is not predicted within the forecast horizon. We introduce a…

Statistics Theory · Mathematics 2026-03-17 Robert J. Taggart , Nicholas Loveday , Simon Louis

Forecasting the short-term spread of an ongoing disease outbreak is a formidable challenge due to the complexity of contributing factors, some of which can be characterized through interlinked, multi-modality variables such as…

Machine Learning · Computer Science 2024-04-11 Hongru Du , Jianan Zhao , Yang Zhao , Shaochong Xu , Xihong Lin , Yiran Chen , Lauren M. Gardner , Hao Frank Yang

The estimation of unknown parameters in simulations, also known as calibration, is crucial for practical management of epidemics and prediction of pandemic risk. A simple yet widely used approach is to estimate the parameters by minimizing…

Methodology · Statistics 2023-06-26 Chih-Li Sung , Ying Hung

Forecasts of multivariate probability distributions are required for a variety of applications. Scoring rules enable the evaluation of forecast accuracy, and comparison between forecasting methods. We propose a theoretical framework for…

Statistics Theory · Mathematics 2026-01-30 Xiaochun Meng , James W. Taylor , Souhaib Ben Taieb , Siran Li

Epidemic forecasts are only as good as the accuracy of epidemic measurements. Is epidemic data, particularly COVID-19 epidemic data, clean and devoid of noise? Common sense implies the negative answer. While we cannot evaluate the…

Populations and Evolution · Quantitative Biology 2023-04-25 Long MA , Piet Van Mieghem , Maksim Kitsak

The emergence of an epidemic evokes the need to monitor its spread and assess and validate any mitigation measures enacted by governments and administrative bodies in real time. We present here a method to observe and quantify this spread…

Populations and Evolution · Quantitative Biology 2024-11-06 Justin Trujillo , Valerica Raicu