English
Related papers

Related papers: Probabilistic Optically-Selective Single-molecule …

200 papers

In the strong lensing regime non-parametric lens models struggle to achieve sufficient angular resolution for a meaningful derivation of the central cluster mass distribution. The problem lies mainly with cluster members which perturb…

Cosmology and Nongalactic Astrophysics · Physics 2015-06-15 Irene Sendra , Jose M. Diego , Tom Broadhurst , Ruth Lazkoz

We report a mass reconstruction of A1689 using Particle Based Lensing (PBL), a new technique for Strong+Weak lensing that allows a variable resolution depending on the data density and the signal-to-noise. Using PBL we also calculate the…

Cosmology and Nongalactic Astrophysics · Physics 2012-01-19 Sanghamitra Deb , Andrea Morandi , Kristian Pedersen , Signe Riemer-Sorensen , David M. Goldberg , Hakon Dahle

CONTEXT: Many massive stars have nearby companions whose presence hamper their characterization through spectroscopy. AIMS: We want to obtain spatially resolved spectroscopy of close massive visual binaries to derive their spectral types.…

Solar and Stellar Astrophysics · Physics 2018-08-01 J. Maíz Apellániz , R. H. Barbá , S. Simón-Díaz , A. Sota , E. Trigueros Páez , J. A. Caballero , E. J. Alfaro

Image superresolution methods process an input image sequence of a scene to obtain a still image with increased resolution. Classical approaches to this problem involve complex iterative minimization procedures, typically with high…

Computer Vision and Pattern Recognition · Computer Science 2007-05-23 Carlos Miravet , Francisco B. Rodriguez

Recent developments in image acquisition literature have miniaturized the confocal laser endomicroscopes to improve usability and flexibility of the apparatus in actual clinical settings. However, miniaturized devices collect less light and…

Image and Video Processing · Electrical Eng. & Systems 2019-07-24 Saeed Izadi , Darren Sutton , Ghassan Hamarneh

We present a weakly supervised deep learning method to perform instance segmentation of cells present in microscopy images. Annotation of biomedical images in the lab can be scarce, incomplete, and inaccurate. This is of concern when…

Computer Vision and Pattern Recognition · Computer Science 2019-08-28 Fidel A. Guerrero-Peña , Pedro D. Marrero Fernandez , Tsang Ing Ren , Alexandre Cunha

Fluorescence lifetime imaging microscopy (FLIM) is a powerful quantitative technique that provides metabolic and molecular contrast, offering strong translational potential for label-free, real-time diagnostics. However, its clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-12-19 Paloma Casteleiro Costa , Parnian Ghapandar Kashani , Xuhui Liu , Alexander Chen , Ary Portes , Julien Bec , Laura Marcu , Aydogan Ozcan

Strongly lensed supernovae (glSNe) provide a powerful, independent method to measure the Hubble constant, $H_{0}$, through time delays between their multiple images. The accuracy of this measurement depends critically on both the precision…

Cosmology and Nongalactic Astrophysics · Physics 2025-11-05 Yushan Xie , Huanyuan Shan , Yiping Shu , Nan Li , Ji Yao , Ran Li , Xiaoyue Cao , Zizhao He , Yin Li , Eric Jullo , Jean-Paul Kneib , Guoliang Li

Magnetic Particle Imaging (MPI) is an emerging imaging modality that maps the spatial distribution of magnetic nanoparticles. The x-space reconstruction in MPI results in highly blurry images, where the resolution depends on both system…

Medical Physics · Physics 2020-01-31 Onur Yorulmaz , Omer Burak Demirel , Yavuz Muslu , Tolga Çukur , Emine U Saritas , A Enis Çetin

Deconvolution is the most commonly used image processing method to remove the blur caused by the point-spread-function (PSF) in optical imaging systems. While this method has been successful in deblurring, it suffers from several…

Image and Video Processing · Electrical Eng. & Systems 2019-10-10 Huangxuan Zhao , Ziwen Ke , Ningbo Chen , Ke Li , Lidai Wang , Xiaojing Gong , Wei Zheng , Liang Song , Zhicheng Liu , Dong Liang , Chengbo Liu

Motivated by the limitations encountered with the commonly used direct reconstruction techniques of producing mass maps, we have developed a multi-resolution maximum-likelihood reconstruction method for producing two dimensional mass maps…

Astrophysics · Physics 2009-11-13 H. Khiabanian , I. P. Dell'Antonio

Spectral clustering is one of the fundamental unsupervised learning methods widely used in data analysis. Sparse spectral clustering (SSC) imposes sparsity to the spectral clustering and it improves the interpretability of the model. This…

Machine Learning · Statistics 2020-11-03 Zhongruo Wang , Bingyuan Liu , Shixiang Chen , Shiqian Ma , Lingzhou Xue , Hongyu Zhao

Mammalian cells have about 30,000-fold more protein molecules than mRNA molecules. This larger number of molecules and the associated larger dynamic range have major implications in the development of proteomics technologies. We examine…

Quantitative Methods · Quantitative Biology 2023-03-14 Michael J. MacCoss , Javier Alfaro , Meni Wanunu , Danielle A. Faivre , Nikolai Slavov

Confocal microscopy has long been a cornerstone technique for visualizing complex interactions and processes within cellular structures. However, achieving super-resolution imaging of multiple organelles and their interactions…

Optics · Physics 2025-08-19 Qinglin Chen , Luwei Wang , Jia Li , Dan Shao , Xiaoyu Weng , Liwei Liu , Dayong Jin , Junle Qu

Single-molecule spectroscopy (SMS) is an exceptionally sensitive technique, but its inherently limited photon budget produces noisy data that can readily lead to subjective analyses, fitting errors, and reduced statistical power, obscuring…

Biological Physics · Physics 2026-03-19 Michael Lovemore , Joshua Botha , Bertus van Heerden , Tjaart Kruger

Diagnostics capable of interrogating dynamics in harsh environments such as plasma have remained essentially unchanged in recent decades. Developments in advanced microscopy techniques will improve our understanding of the physics involved…

Image super-resolution using self-optimizing mask via fractional-order gradient interpolation and reconstruction aims to recover detailed information from low-resolution images and reconstruct them into high-resolution images. Due to the…

Computer Vision and Pattern Recognition · Computer Science 2017-03-21 Qi Yang , Yanzhu Zhang , Tiebiao Zhao , YangQuan Chen

Recent technological advances in cutting-edge ultrasensitive fluorescence microscopy have allowed single-molecule imaging experiments in living cells across all three domains of life to become commonplace. Single-molecule live-cell data is…

Biomolecules · Quantitative Biology 2015-04-15 Mark Leake

Advances in microscopy imaging enable researchers to visualize structures at the nanoscale level thereby unraveling intricate details of biological organization. However, challenges such as image noise, photobleaching of fluorophores, and…

Image and Video Processing · Electrical Eng. & Systems 2024-09-19 Pamela Osuna-Vargas , Maren H. Wehrheim , Lucas Zinz , Johanna Rahm , Ashwin Balakrishnan , Alexandra Kaminer , Mike Heilemann , Matthias Kaschube

Single-pixel imaging (SPI) is a novel imaging technique whose working principle is based on the compressive sensing (CS) theory. In SPI, data is obtained through a series of compressive measurements and the corresponding image is…

Image and Video Processing · Electrical Eng. & Systems 2022-07-15 Stephen L. H. Lau , Edwin K. P. Chong