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An important parameter for COVID-19 is the case fatality rate (CFR). It has been applied to wide applications, including the measure of the severity of the infection, the estimation of the number of infected cases, risk assessment etc.…

Applications · Statistics 2026-02-10 Donghui Yan , Aiyou Chen , Buqing Yang

To make informative public policy decisions in battling the ongoing COVID-19 pandemic, it is important to know the disease prevalence in a population. There are two intertwined difficulties in estimating this prevalence based on testing…

Methodology · Statistics 2020-12-01 Bryan Cai , John P. A. Ioannidis , Eran Bendavid , Lu Tian

Countries officially record the number of COVID-19 cases based on medical tests of a subset of the population with unknown participation bias. For prevalence estimation, the official information is typically discarded and, instead, small…

Methodology · Statistics 2020-12-25 Stéphane Guerrier , Christoph Kuzmics , Maria-Pia Victoria-Feser

Following the emergence of a novel coronavirus (SARS-CoV-2) and its spread outside of China, Europe has experienced large epidemics. In response, many European countries have implemented unprecedented non-pharmaceutical interventions…

Knowing the true effect size of clinical interventions in randomised clinical trials is key to informing the public health policies. Vaccine efficacy is defined in terms of the relative risk or the ratio of two disease risks. However, only…

Methodology · Statistics 2021-02-03 Yasin Memari

In this short technical report we model, within the Bayesian framework, the rate of positive tests reported by the the State of Indiana, accounting also for the substantial variability (and overdispeartion) in the daily count of the tests…

Methodology · Statistics 2020-07-14 Ben Boukai , Jiayue Wang

In the initial wave of the COVID-19 pandemic we observed great discrepancies in both infection and mortality rates between countries. Besides the biological and epidemiological factors, a multitude of social and economic criteria also…

Physics and Society · Physics 2022-01-14 Viktor Stojkoski , Zoran Utkovski , Petar Jolakoski , Dragan Tevdovski , Ljupco Kocarev

In this paper, we estimate the seroprevalence against COVID-19 by country and derive the seroprevalence over the world. To estimate seroprevalence, we use serological surveys (also called the serosurveys) conducted within each country. When…

Applications · Statistics 2022-02-01 Kwangmin Lee , Seongmin Kim , Seongil Jo , Jaeyong Lee

An epidemic disease caused by a new coronavirus has spread in Northern Italy with a strong contagion rate. We implement an SEIR model to compute the infected population and number of casualties of this epidemic. The example may ideally…

Populations and Evolution · Quantitative Biology 2020-05-12 Jose' M. Carcione , Juan E. Santos , Claudio Bagaini , Jing Ba

Epidemiological forecasts are beset by uncertainties about the underlying epidemiological processes, and the surveillance process through which data are acquired. We present a Bayesian inference methodology that quantifies these…

Obtaining up to date information on the number of UK COVID-19 regional infections is hampered by the reporting lag in positive test results for people with COVID-19 symptoms. In the UK, for "Pillar 2" swab tests for those showing symptoms,…

The role of epidemiological models is crucial for informing public health officials during a public health emergency, such as the COVID-19 pandemic. However, traditional epidemiological models fail to capture the time-varying effects of…

Methodology · Statistics 2022-06-17 Adam Spannaus , Theodore Papamarkou , Samantha Erwin , J. Blair Christian

Large scale virological testing of SARS-Cov2 is implemented since May 2020 in France. We assume that the positivity of asymptomatic people not being contact cases (ANBC) is representative of the positivity of the whole French population,…

Populations and Evolution · Quantitative Biology 2020-11-03 Guillaume Malpuech , Anne Tournadre , Francois Berry , Laurent Gerbaud

We provide a probabilistic SIRD model for the COVID-19 pandemic in Italy, where we allow the infection, recovery and death rates to be random. In particular, the underlying random factor is driven by a fractional Brownian motion. Our model…

Populations and Evolution · Quantitative Biology 2020-08-04 Elisa Alòs , Maria Elvira Mancino , Raúl Merino , Simona Sanfelici

Accurate estimation of disease prevalence is essential for guiding public health strategies. Imperfect diagnostic tests can cause misclassification errors-false positives (FP) and false negatives (FN)-that may skew estimates if unaddressed.…

We introduce a new probabilistic model to estimate the real spread of the novel SARS-CoV-2 virus along regions or countries. Our model simulates the behavior of each individual in a population according to a probabilistic model through an…

Populations and Evolution · Quantitative Biology 2020-05-05 Marcos Matabuena , Carlos Meijide-García , Pablo Rodríguez-Mier , Víctor Leborán

Objective: To estimate the number of deaths in Peru due to COVID-19. Design: With a priori information obtained from the daily number of deaths due to CODIV-19 in China and data from the Peruvian authorities, we constructed a predictive…

Applications · Statistics 2020-04-08 Cristian Bayes , Victor Sal y Rosas , Luis Valdivieso

We used Bayesian model inversion to estimate epidemic parameters from the reported case and death rates from seven countries using data from late January 2020 to April 5th 2020. Two distinct generative model types were employed: first a…

A deterministic model with testing of infected individuals has been proposed to investigate the potential consequences of the impact of testing strategy. The model exhibits global dynamics concerning the disease-free and a unique endemic…

Populations and Evolution · Quantitative Biology 2023-05-24 Sarita Bugalia , Jai Prakash Tripathi

While COVID-19 has resulted in a significant increase in global mortality rates, the impact of the pandemic on mortality from other causes remains uncertain. To gain insight into the broader effects of COVID-19 on various causes of death,…

Applications · Statistics 2024-09-05 Wei Zhang , Antonietta Mira , Ernst C. Wit