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The COVID-19 infection fatality rate (IFR) is the proportion of individuals infected with SARS-CoV-2 who subsequently die. As COVID-19 disproportionately affects older individuals, age-specific IFR estimates are imperative to facilitate…

The Infection Fatality Rate (IFR) of COVID-19 is difficult to estimate because the number of infections is unknown and there is a lag between each infection and the potentially subsequent death. We introduce a new approach for estimating…

Computers and Society · Computer Science 2021-09-29 Naveen Pai , Sean Zhang , Mor Harchol-Balter

Understanding how widely COVID-19 has spread is critical for examining the pandemic's progression. Despite efforts to carefully monitor the pandemic, the number of confirmed cases may underestimate the total number of infections. We…

Populations and Evolution · Quantitative Biology 2020-05-27 Christina Bohk-Ewald , Christian Dudel , Mikko Myrskylä

The infection fatality rate (IFR) of COVID-19 is one of the measures of disease impact that can be of importance for policy making. Here we show that many of the studies on which these estimates are based are scientifically flawed for…

Populations and Evolution · Quantitative Biology 2020-12-24 Chen Shen , Derrick Van Gennep , Alexander F. Siegenfeld , Yaneer Bar-Yam

The relative case fatality rates (CFRs) between groups and countries are key measures of relative risk that guide policy decisions regarding scarce medical resource allocation during the ongoing COVID-19 pandemic. In the middle of an active…

Quantitative Methods · Quantitative Biology 2022-12-08 Anastasios Nikolas Angelopoulos , Reese Pathak , Rohit Varma , Michael I. Jordan

SARS-CoV-2 has disrupted the life of billions of people around the world since the first outbreak was officially declared in China at the beginning of 2020. Yet, important questions such as how deadly it is or its degree of spread within…

Populations and Evolution · Quantitative Biology 2021-03-01 Beatriz Seoane

The determination of the infection fatality rate (IFR) for the novel SARS-CoV-2 coronavirus is a key aim for many of the field studies that are currently being undertaken in response to the pandemic. The IFR together with the basic…

There are many hard-to-reconcile numbers circulating concerning Covid-19. Using reports from random testing, the fatality ratio per infection is evaluated and used to extract further information on the actual fraction of infections and the…

Populations and Evolution · Quantitative Biology 2020-05-25 Allen Caldwell , Vasyl Hafych , Oliver SChulz , Lolian Shtembari

I propose novel partial identification bounds on infection prevalence from information on test rate and test yield. The approach utilizes user-specified bounds on (i) test accuracy and (ii) the extent to which tests are targeted, formalized…

Econometrics · Economics 2024-07-03 Jörg Stoye

We propose a partial identification method for estimating disease prevalence from serology studies. Our data are results from antibody tests in some population sample, where the test parameters, such as the true/false positive rates, are…

Methodology · Statistics 2020-06-30 Panos Toulis

During an epidemic outbreak of a new disease, the probability of dying once infected is considered an important though difficult task to be computed. Since it is very hard to know the true number of infected people, the focus is placed on…

Methodology · Statistics 2024-03-26 Agustín Alvarez , Marina Fragalá , Marina Valdora

Knowing the infection fatality ratio (IFR) is of crucial importance for evidence-based epidemic management: for immediate planning; for balancing the life years saved against the life years lost due to the consequences of management; and…

Quantitative Methods · Quantitative Biology 2020-08-11 Simon N. Wood , Ernst C. Wit , Matteo Fasiolo , Peter J. Green

In the last months, due to the emergency of Covid-19, questions related to the fact of belonging or not to a particular class of individuals (`infected or not infected'), after being tagged as `positive' or `negative' by a test, have never…

Populations and Evolution · Quantitative Biology 2020-11-23 Giulio D'Agostini , Alfredo Esposito

To strengthen inferences meta analyses are commonly used to summarize information from a set of independent studies. In some cases, though, the data may not satisfy the assumptions underlying the meta analysis. Using three Bayesian methods…

Applications · Statistics 2022-04-07 Dexter Cahoy , Joseph Sedransk

The infection fatality rate (IFR) of the Coronavirus Disease 2019 (COVID-19) is one of the most discussed figures in the context of this pandemic. Using German COVID-19 surveillance data and age-group specific IFR estimates from multiple…

Populations and Evolution · Quantitative Biology 2021-01-22 Christian Staerk , Tobias Wistuba , Andreas Mayr

As a consequence of missing data on tests for infection and imperfect accuracy of tests, reported rates of population infection by the SARS CoV-2 virus are lower than actual rates of infection. Hence, reported rates of severe illness…

Econometrics · Economics 2020-04-27 Charles F. Manski , Francesca Molinari

The first cases of COVID-19 in France were detected on January 24, 2020. The number of screening tests carried out and the methodology used to target the patients tested do not allow for a direct computation of the real number of cases and…

Populations and Evolution · Quantitative Biology 2020-05-15 Lionel Roques , Etienne Klein , Julien Papax , Antoine Sar , Samuel Soubeyrand

I use a very simple deterministic model for the spread of Covid-19 in a large population. Using this to compare the relative decay of the number of deaths per day between different regions in Italy, Spain and England, each applying in…

Populations and Evolution · Quantitative Biology 2020-05-26 Robert S Thorne

There are many sources of data giving information about the number of SARS-CoV-2 infections in the population, but all have major drawbacks, including biases and delayed reporting. For example, the number of confirmed cases largely…

Applications · Statistics 2022-06-08 Nicholas J. Irons , Adrian E. Raftery

The case fatality ratio (CFR) for COVID-19 is difficult to estimate. One difficulty is due to ignoring or overestimating time delay between reporting and death. We claim that all of these cause large errors and artificial time dependence of…

Populations and Evolution · Quantitative Biology 2020-07-02 Phoebus Rosakis , Maria Marketou
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