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Recently, deep neural networks have greatly advanced histopathology image segmentation but usually require abundant annotated data. However, due to the gigapixel scale of whole slide images and pathologists' heavy daily workload, obtaining…

Computer Vision and Pattern Recognition · Computer Science 2023-03-13 Wentao Pan , Jiangpeng Yan , Hanbo Chen , Jiawei Yang , Zhe Xu , Xiu Li , Jianhua Yao

In industrial X-ray Computed Tomography (CT), the need for rapid in-line inspection is critical. Sparse-angle tomography plays a significant role in this by reducing the required number of projections, thereby accelerating processing and…

Computer Vision and Pattern Recognition · Computer Science 2025-05-27 Tianyuan Wang , Felix Lucka , Daniël M. Pelt , K. Joost Batenburg , Tristan van Leeuwen

Histopathological examination of surgical biopsies, such as in glioma and glioblastoma resection, is hindered in current clinical practice by the long times required for the laboratory analysis and pathological screening, typically taking…

Progress in high-resolution x-ray microtomography has provided us with a practical approach to determining three-dimensional (3D) structures of opaque samples at micrometer to submicrometer resolution. In this review, we give an…

Biological Physics · Physics 2016-09-09 Ryuta Mizutani , Yoshio Suzuki

Three-dimensional X-ray histology techniques offer a non-invasive alternative to conventional 2D histology, enabling volumetric imaging of biological tissues without the need for physical sectioning or chemical staining. However, the…

Image and Video Processing · Electrical Eng. & Systems 2025-09-12 Sarah C. Irvine , Christian Lucas , Diana Krüger , Bianca Guedert , Julian Moosmann , Berit Zeller-Plumhoff

Computerized tomography (CT) has been used for decades by medical professionals to detect and diagnose injuries and ailments. CT scanners are based on interesting physics, but due to their bulk, cost, and safety, hands on experience with a…

Physics Education · Physics 2021-01-28 Vincent Daley , Owen Paetkau , Mark Paetkau

Analysis of three-dimensional biological samples is critical to understanding tissue function and the mechanisms of disease. Many chronic conditions, like neurodegenerative diseases and cancers, correlate with complex tissue changes that…

Biological Physics · Physics 2019-11-06 Jiaming Guo , Camille Artur , Jason L. Eriksen , David Mayerich

Digital Breast Tomosynthesis is an X-ray imaging technique that allows a volumetric reconstruction of the breast, from a small number of low-dose two-dimensional projections. Although it is already used in clinical setting, enhancing the…

Numerical Analysis · Mathematics 2020-07-21 Elena Morotti , Elena Loli Piccolomini

Imaging of microvasculature is primarily performed with X-ray contrast agents, owing to the wide availability of absorption-contrast laboratory source microCT compared to phase contrast capable devices. Standard commercial contrast agents…

Tissues and Organs · Quantitative Biology 2023-01-18 Willy Kuo , Ngoc An Le , Bernhard Spingler , Georg Schulz , Bert Müller , Vartan Kurtcuoglu

The unprecedented rate at which synchrotron radiation facilities are producing micro-computed (micro-CT) datasets has resulted in an overwhelming amount of data that scientists struggle to browse and interact with in real-time. Thousands of…

Computer Vision and Pattern Recognition · Computer Science 2023-11-28 Nicholas Tan Jerome , Suren Chilingaryan , Thomas van de Kamp , Andreas Kopmann

Conventional histopathology has long been essential for disease diagnosis, relying on visual inspection of tissue sections. Immunohistochemistry aids in detecting specific biomarkers but is limited by its single-marker approach, restricting…

Convolutional Neural Networks (CNN) based image reconstruction methods have been intensely used for X-ray computed tomography (CT) reconstruction applications. Despite great success, good performance of this data-based approach critically…

Computer Vision and Pattern Recognition · Computer Science 2019-01-31 Ziling Wu , Abdulaziz Alorf , Ting Yang , Ling Li , Yunhui Zhu

Digital pathology, augmented by artificial intelligence (AI), holds significant promise for improving the workflow of pathologists. However, challenges such as the labor-intensive annotation of whole slide images (WSIs), high computational…

Image and Video Processing · Electrical Eng. & Systems 2025-04-18 Walid Rehamnia , Alexandra Getmanskaya , Evgeniy Vasilyev , Vadim Turlapov

Ultrasound b-mode imaging is a qualitative approach and diagnostic quality strongly depends on operators' training and experience. Quantitative approaches can provide information about tissue properties; therefore, can be used for…

Image and Video Processing · Electrical Eng. & Systems 2023-11-23 Farnaz Khun Jush , Markus Biele , Peter M. Dueppenbecker , Andreas Maier

Tissue semantic segmentation is one of the key tasks in computational pathology. To avoid the expensive and laborious acquisition of pixel-level annotations, a wide range of studies attempt to adopt the class activation map (CAM), a…

Computer Vision and Pattern Recognition · Computer Science 2024-12-31 Zijie Fang , Yifeng Wang , Peizhang Xie , Zhi Wang , Yongbing Zhang

Marking tumors and organs is a challenging task suffering from both inter- and intra-observer variability. The literature quantifies observer variability by generating consensus among multiple experts when they mark the same image.…

Computer Vision and Pattern Recognition · Computer Science 2017-10-02 H. R. Tizhoosh , G. J. Czarnota

We propose a 3D neural network with specific loss functions for quantitative computed tomography (QCT) noise reduction to compute micro-structural parameters such as tissue mineral density (TMD) and bone volume ratio (BV/TV) with…

Image and Video Processing · Electrical Eng. & Systems 2020-11-11 Felix Thomsen , José M. Fuertes García , Manuel Lucena , Juan Pisula , Rodrigo de Luis García , Jan Broggrefe , Claudio Delrieux

Histopathological analysis has been transformed by serial section-based methods, advancing beyond traditional 2D histology to enable volumetric and microstructural insights in oncology and inflammatory disease diagnostics. This review…

Tissues and Organs · Quantitative Biology 2025-08-05 Zhenfeng Zhuang , Min Cen , Lei Jiang , Qiong Peng , Yihuang Hu , Hong-Yu Zhou , Liansheng Wang

Early and correct diagnosis is a very important aspect of cancer treatment. Detection of tumour in Computed Tomography scan is a tedious and tricky task which requires expert knowledge and a lot of human working hours. As small human error…

Computer Vision and Pattern Recognition · Computer Science 2018-01-08 Devesh Walawalkar

Multi-organ segmentation of 3D medical images is fundamental with meaningful applications in various clinical automation pipelines. Although deep learning has achieved superior performance, the time and memory consumption of segmenting the…

Computer Vision and Pattern Recognition · Computer Science 2025-11-12 Xueqi Guo , Halid Ziya Yerebakan , Yoshihisa Shinagawa , Kritika Iyer , Gerardo Hermosillo Valadez