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Effective transperineal ultrasound image guidance in prostate external beam radiotherapy requires consistent alignment between probe and prostate at each session during patient set-up. Probe placement and ultrasound image inter-pretation…

Computer Vision and Pattern Recognition · Computer Science 2020-10-07 Alexander Grimwood , Helen McNair , Yipeng Hu , Ester Bonmati , Dean Barratt , Emma Harris

The specific absorbed fractions (SAF) for self- and cross-irradiation are effective tools for the internal dose estimation of inhalation and ingestion intakes of radionuclides. A set of SAFs of photon and electron were calculated using the…

Medical Physics · Physics 2014-10-31 Wen Wang , Meng-yun Cheng , Peng-cheng Long , Li-qin Hu

Objective: To develop and validate an independent Monet Carlo dose calculation engine to support for software verification of treatment planning systems and quality assurance workflow. Method: GATE Monte Carlo toolkit was employed to…

Medical Physics · Physics 2021-07-27 A. Asadi , A. Akhavanallaf , S. A. Hosseini , N. vosoughi , H. Zaidi

Purpose: Prior AI-based dose prediction studies in photon and proton therapy often neglect underlying physics, limiting their generalizability to handle outlier clinical cases, especially for pencil beam scanning proton therapy (PBSPT). Our…

With the increasing complexity of external beam therapy, so-called "end-to-end" tests are intended to cover all steps from therapy planning to follow-up to fulfill the high demands on quality assurance. As magnetic resonance imaging (MRI)…

This study investigates the sensitivity and specificity of the MapCHECK phantom housed in MapPHAN to errors in conformal arc Stereotactic Ablative Body Radiotherapy (SABR). A specific focus is applied to Organ At Risk (OAR) dosimetry.…

Medical Physics · Physics 2025-08-22 Nathan I. N. Henry , Christopher M. Thompson , Steven Marsh , Jack D. Aylward

In this paper, we investigate protection strategies of sensitive body anatomy against the irradiation to the cancerous moving tumors in intensity modulated radiation therapy. Inspired by optimization techniques developed in statistical…

Medical Physics · Physics 2009-07-29 Ramin M. Abolfath , Lech Papiez

This paper deals with the classic radiotherapy dose fractionation problem for cancer tumors concerning the following goals: a) To maximize the effect of radiation on the tumor, restricting the effect produced to the organs at risk (healing…

Optimization and Control · Mathematics 2021-02-17 Luis Alberto Fernández , Lucía Fernández

Purpose: To develop a Monte Carlo (MC) therapeutic dose calculation toolkit of a recently released ring gantry linac in Geant4 (Version 10.7) for secondary dose validation of radiotherapy plan. Methods: For the Halcyon (Varian Medical…

Medical Physics · Physics 2022-10-04 Ruirui Liu , Zhen Ji , Xiandong Zhao , Tianyu Zhao , Abhishek Sethi , Daren Sawkey , Bin Cai

Purpose: Highlight the distinctions, both in terms of concept and numerical values, of the various definitions that can be established for the dose rate in PBS proton therapy. Methods: In an in silico study, five definitions of the dose…

Medical Physics · Physics 2023-07-17 Sylvain Deffet , Valentin Hamaide , Edmond Sterpin

Quantitative Magnetic Resonance Imaging (qMRI) provides researchers insight into pathological and physiological alterations of living tissue, with the help of which researchers hope to predict (local) therapeutic efficacy early and…

Applications · Statistics 2008-07-30 Xiaoxi Zhang , Timothy D. Johnson , Roderick J. A. Little , Yue Cao

Autonomous robotic systems hold potential for improving renal tumor resection accuracy and patient outcomes. We present a fluorescence-guided robotic system capable of planning and executing incision paths around exophytic renal tumors with…

Pharmacological challenge imaging has mapped, but rarely quantified, the sensitivity of a biological system to a given drug. We describe a novel method called rapid quantitative pharmacodynamic imaging. This method combines…

Quantitative Methods · Quantitative Biology 2014-05-28 Kevin J. Black , Jonathan M. Koller , Brad D. Miller

Modeling the absorbed dose during X-ray imaging is essential for optimizing radiation exposure. Monte Carlo simulations (MCS) are the gold standard for precise 3D dose estimation but require significant computation time. Deep learning…

Medical Physics · Physics 2025-02-14 Maxime Rousselot , Jing Zhang , Didier Benoit , Chi-Hieu Pham , Julien Bert

In this report simulations of 192Ir source located inside a phantom designed for measuring the absorbed dose and radioactive source position are presented. Monte Carlo simulations were performed and results were compared with a theoretical…

Medical Physics · Physics 2018-11-27 Samuel Chiquita

For the in vivo range verification in proton therapy, it has been tried to measure the spatial distribution of the prompt gammas generated by the proton-induced interactions with the close relationship with the proton dose distribution.…

Medical Physics · Physics 2015-03-13 Wook-Geun Shin , Chul Hee Min , Jae-Ik Shin , Jong Hwi Jeong , Se Byeong Lee

Monte Carlo (MC) simulations provide gold-standard accuracy for carbon ion therapy dose calculations but are computationally intensive. Analytical pencil beam algorithms offer speed but reduced accuracy in heterogeneous tissues. We…

We propose to develop deep learning models that can predict Pareto optimal dose distributions by using any given set of beam angles, along with patient anatomy, as input to train the deep neural networks. We implement and compare two deep…

Medical Physics · Physics 2021-01-27 Gyanendra Bohara , Azar Sadeghnejad Barkousaraie , Steve Jiang , Dan Nguyen

Monte Carlo simulation with PENELOPE (v.~2003) is applied to calculate Leksell Gamma Knife$^{\circledR}$ dose distributions for heterogeneous phantoms. The usual spherical water phantom is modified with a spherical bone shell simulating the…

Medical Physics · Physics 2009-11-11 Feras M. O. Al-Dweri , E. Leticia Rojas , Antonio M. Lallena

CD16 is a MATLAB-based dosimetry system designed for rapid estimation of organ doses for x-ray guided cardiac catheterization procedures. CD16 is principally designed for epidemiological studies in which dose estimates are required for…

Medical Physics · Physics 2018-07-17 Richard W Harbron , Mark S Pearce , Claire-Louise Chapple
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