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High-frequency heart rate variability (HRV) has identified parasympathetic nervous system alterations in autism spectrum disorder (ASD). In a cohort of school-aged children with and without ASD, we test a set of alternative linear and…

Quantitative Methods · Quantitative Biology 2020-04-27 Martin G Frasch , Chao Shen , Hau-Tieng Wu , Alexander Mueller , Emily Neuhaus , Raphael A. Bernier , Dana Kamara , Theodore P. Beauchaine

Current management of bipolar disorder relies on self-reported questionnaires and interviews with clinicians. The development of objective measures of deteriorating mood may also allow for early interventions to take place to avoid…

Signal Processing · Electrical Eng. & Systems 2020-07-08 Oliver Carr , Fernando Andreotti , Kate E. A. Saunders , Niclas Palmius , Guy M. Goodwin , Maarten De Vos

In numerous applications data are observed at random times and an estimated graph of the spectral density may be relevant for characterizing and explaining phenomena. By using a wavelet analysis, one derives a nonparametric estimator of the…

Statistics Theory · Mathematics 2009-11-27 Jean-Marc Bardet , Pierre Bertrand

We analize heartbeat time-series corresponding to several groups of individuals (healthy, heart transplanted, with congestive heart failure (CHF), after myocardial infarction (MI), hypertensive), looking for short- and long-time statistical…

Soft Condensed Matter · Physics 2007-05-23 Paolo Allegrini , Rita Balocchi , Santi Chillemi , Paolo Grigolini , Luigi Palatella , Giacomo Raffaelli

Agitation is one of the neuropsychiatric symptoms with high prevalence in dementia which can negatively impact the Activities of Daily Living (ADL) and the independence of individuals. Detecting agitation episodes can assist in providing…

Continuous monitoring of respiratory activity is desirable in many clinical applications to detect respiratory events. Non-contact monitoring of respiration can be achieved with near- and far-infrared spectrum cameras. However, current…

Signal Processing · Electrical Eng. & Systems 2020-06-02 Gaetano Scebba , Giulia Da Poian , Walter Karlen

This study presents a nonlinear signal processing method for accurate radar-based heartbeat interval estimation by exploiting the periodicity of higher-order harmonics inherent in heartbeat signals. Unlike conventional approaches that…

Signal Processing · Electrical Eng. & Systems 2025-07-29 Kohei Shimomura , Chi-Hsuan Lee , Takuya Sakamoto

$\bullet$ Background : In Heart rate variability analysis, the rate-rate time series suffer often from aperiodic non-stationarity, presence of ectopic beats etc. It would be hard to extract helpful information from the original signals. 10…

Quantitative Methods · Quantitative Biology 2016-05-20 Binbin Xu , Rémi Dubois , Oriol Pont , Hussein Yahia

Circadian rhythms are a process of the sleep-wake cycle that regulates the physical, mental and behavioural changes in all living beings with a period of roughly 24 h. Wearable accelerometers are typically used in livestock applications to…

Quantitative Methods · Quantitative Biology 2022-09-07 Victoria Rhodes , Maureen Maguire , Meghana Shetty , Conor McAloon , Alan F. Smeaton

Dementia is a neurological syndrome marked by cognitive decline. Alzheimer's disease (AD) and Frontotemporal dementia (FTD) are the common forms of dementia, each with distinct progression patterns. EEG, a non-invasive tool for recording…

Signal Processing · Electrical Eng. & Systems 2024-08-21 Shivani Ranjan , Ayush Tripathi , Harshal Shende , Robin Badal , Amit Kumar , Pramod Yadav , Deepak Joshi , Lalan Kumar

People living with dementia (PLwD) often show gradual shifts in how they communicate, becoming less expressive, more repetitive, or drifting off-topic in subtle ways. While caregivers may notice these changes informally, most computational…

Artificial Intelligence · Computer Science 2025-11-21 Joy Lai , Alex Mihailidis

In mixed longitudinal studies, a group of subjects enter the study at different ages (cross-sectional) and are followed for successive years (longitudinal). In the context of such studies, we consider nonparametric covariance estimation…

Methodology · Statistics 2020-12-02 Anru R. Zhang , Kehui Chen

Depression and Attention Deficit Hyperactivity Disorder (ADHD) stand out as the common mental health challenges today. In affective computing, speech signals serve as effective biomarkers for mental disorder assessment. Current research,…

Audio and Speech Processing · Electrical Eng. & Systems 2025-03-05 Shuanglin Li , Siyang Song , Rajesh Nair , Syed Mohsen Naqvi

Despite the widespread diffusion of nonlinear methods for heart rate variability (HRV) analysis, the presence and the extent to which nonlinear dynamics contribute to short-term HRV is still controversial. This work aims at testing the…

Our research focuses on analysing human activities according to a known behaviorist scenario, in case of noisy and high dimensional collected data. The data come from the monitoring of patients with dementia diseases by wearable cameras. We…

This paper estimates the stochastic process of how dementia incidence evolves over time. We proceed in two steps: first, we estimate a time trend for dementia using a multi-state Cox model. The multi-state model addresses problems of both…

Applications · Statistics 2025-09-10 Jérôme R. Simons , Yuntao Chen , Eric Brunner , Eric French

Stroke is known as a major global health problem, and for stroke survivors it is key to monitor the recovery levels. However, traditional stroke rehabilitation assessment methods (such as the popular clinical assessment) can be subjective…

Signal Processing · Electrical Eng. & Systems 2022-12-27 Xi Chen , Yu Guan , Jian Qing Shi , Xiu-Li Du , Janet Eyre

Different measures of heart rate variability and particularly of respiratory sinus arrhythmia are widely used in research and clinical applications. Inspired by the ideas from the theory of coupled oscillators, we use simultaneous…

Detrended fluctuation analysis (DFA), suitable for the analysis of nonstationary time series, has confirmed the existence of persistent long-range correlations in healthy heart rate variability data. In this paper, we present the…

Medical Physics · Physics 2009-11-10 J. C. Echeverria , M. S. Woolfson , J. A. Crowe , B. R. Hayes-Gill , G. D. H. Croaker , H. Vyas

We develop a framework to uncover and analyze dynamical anomalies from massive, nonlinear and non-stationary time series data. The framework consists of three steps: preprocessing of massive data sets to eliminate erroneous data segments,…

Medical Physics · Physics 2016-12-26 Liang Huang , Xuan Ni , William L. Ditto , Mark Spano , Paul R. Carney , Ying-Cheng Lai