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Monitoring key elements of disease dynamics (e.g., prevalence, case counts) is of great importance in infectious disease prevention and control, as emphasized during the COVID-19 pandemic. To facilitate this effort, we propose a new…

Methodology · Statistics 2024-10-10 Lin Ge , Yuzi Zhang , Lance A. Waller , Robert H. Lyles

Group testing is a technique which avoids individually testing $n$ samples for a rare disease and instead tests $n < p$ pools, where a pool consists of a mixture of small, equal portions of a subset of the $p$ samples. Group testing saves…

Statistics Theory · Mathematics 2023-08-29 Richeek Das , Aaron Jerry Ninan , Adithya Bhaskar , Ajit Rajwade

Surveillance of diseases in a pandemic is an important part of public health policy. Diagnostic testing at the individual level is often infeasible due to resource constraints. To circumvent these constraints, group testing can be applied.…

Computation · Statistics 2026-04-01 Michael Balzer , Kainat Khowaja , Christiane Fuchs

Structure-based Deep Fusion models were recently shown to outperform several physics- and machine learning-based protein-ligand binding affinity prediction methods. As part of a multi-institutional COVID-19 pandemic response, over 500…

Mina and Andersen, authors of the Perspectives in Science: COVID-19 Testing: One Size Does Not Fit All have referred to results and adopted conclusions from recently published governmental report Pavelka et al. "The effectiveness of…

Populations and Evolution · Quantitative Biology 2021-01-05 Jozef Černák

Group testing has recently attracted significant attention from the research community due to its applications in diagnostic virology. An instance of the group testing problem includes a ground set of individuals which includes a small…

Information Theory · Computer Science 2022-02-25 Esmaeil Karimi , Anoosheh Heidarzadeh , Krishna R. Narayanan , Alex Sprintson

The group testing problem asks for efficient pooling schemes and algorithms that allow to screen moderately large numbers of samples for rare infections. The goal is to accurately identify the infected samples while conducting the least…

Artificial Intelligence · Computer Science 2021-05-19 AminCoja-Oghlan , Max Hahn-Klimroth , Philipp Loick , Manuel Penschuck

The current COVID-19 pandemic is a serious threat to humanity that directly affects the lungs. Automatic identification of COVID-19 is a challenge for health care officials. The standard gold method for diagnosing COVID-19 is Reverse…

Image and Video Processing · Electrical Eng. & Systems 2022-08-09 Briskline Kiruba S , Petchiammal A , D. Murugan

Pooled testing is widely used for screening for viral or bacterial infections with low prevalence when individual testing is not cost-efficient. Pooled testing with qualitative assays that give binary results has been well-studied. However,…

Methodology · Statistics 2020-11-03 Tao Liu , Joseph W Hogan , Wanning Su , Yizhen Xu , Michael J Daniels , Kantor Rami

Based on the well known SIR model, this paper develops a model for predicting the number of necessary testings of asymptomatic persons in order to push Reff below 1, thus suppressing an outbreak. The model considers R0, time for obtaining a…

Populations and Evolution · Quantitative Biology 2020-05-01 Helmut Hlavacs

Timely and rapid diagnoses are core to informing on optimum interventions that curb the spread of COVID-19. The use of medical images such as chest X-rays and CTs has been advocated to supplement the Reverse-Transcription Polymerase Chain…

Image and Video Processing · Electrical Eng. & Systems 2023-05-31 Ogechukwu Ukwandu , Hanan Hindy , Elochukwu Ukwandu

In this paper, we consider the problem of designing optimal pooling matrix for group testing (for example, for COVID-19 virus testing) with the constraint that no more than $r>0$ samples can be pooled together, which we call "dilution…

Quantitative Methods · Quantitative Biology 2020-08-06 Jirong Yi , Myung Cho , Xiaodong Wu , Raghu Mudumbai , Weiyu Xu

Recent advancements in large language models (LLMs) integrating explicit reasoning, such as OpenAI's o3-mini, DeepSeek-R1, and QWQ-32B, enable smaller models to solve complex tasks by generating intermediate reasoning steps prior to…

Machine Learning · Computer Science 2025-03-25 Jaeyeon Lee , Guantong Qi , Matthew Brady Neeley , Zhandong Liu , Hyun-Hwan Jeong

A major public health issue is the growing resistance of bacteria to antibiotics. An important part of the needed response is the discovery and development of new antimicrobial strategies. These require the screening of potential new drugs,…

Applications · Statistics 2026-02-19 Byran Smucker , Benjamin Brennan , Emily Rego , Meng Wu , Zhihong Lin , Brian Ahmer , Blake Peterson

Testing is an important part of tackling the COVID-19 pandemic. Availability of testing is a bottleneck due to constrained resources and effective prioritization of individuals is necessary. Here, we discuss the impact of different…

Machine Learning · Computer Science 2020-07-30 Hagit Grushka-Cohen , Raphael Cohen , Bracha Shapira , Jacob Moran-Gilad , Lior Rokach

We provide a predictive analysis of the spread of COVID-19, also known as SARS-CoV-2, using the dataset made publicly available online by the Johns Hopkins University. Our main objective is to provide predictions of the number of infected…

Machine Learning · Computer Science 2020-05-26 Alireza M. Javid , Xinyue Liang , Arun Venkitaraman , Saikat Chatterjee

Pooled and individual disease testing are common methods for determining the population prevalences of diseases. Recently, researchers have used Monte Carlo Markov Chain methods to estimate population prevalence from the combined streams of…

Methodology · Statistics 2023-08-23 Matthew Ritch , Charles Copley

Group testing is a method of identifying infected patients by performing tests on a pool of specimens collected from patients. For the case in which the test returns a false result with finite probability, we propose Bayesian inference and…

Machine Learning · Statistics 2020-07-15 Ayaka Sakata

We consider the optimal strategy for laboratory testing of biological samples when we wish to know the results for each sample rather than the average prevalence of positive samples. If the proportion of positive samples is low considerable…

Quantitative Methods · Quantitative Biology 2010-07-29 Brian G. Williams

Recent epidemiological data report that worldwide more than 53 million people have been infected by SARS-CoV-2, resulting in 1.3 million deaths. The disease has been spreading very rapidly and few months after the identification of the…