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As the COVID19 spreads across the world, prevention measures are becoming the essential weapons to combat the pandemic in the period of crisis. The lockdown measure is the most controversial one as it imposes an overwhelming impact on our…

Physics and Society · Physics 2021-02-12 Yuting Fu , Haitao Xiang , Hanqing Jin , Ning Wang

The current COVID-19 pandemic and subsequent lockdowns have highlighted the close and delicate relationship between a country's public health and economic health. Macroeconomic models that use preexisting epidemic models to calculate the…

Physics and Society · Physics 2020-07-01 Erhan Bayraktar , Asaf Cohen , April Nellis

This article considers the optimal control of the SIR model with both transmission and treatment uncertainty. It follows the model presented in Gatto and Schellhorn (2021). We make four significant improvements on the latter paper. First,…

Optimization and Control · Mathematics 2021-05-20 Yujia Ding , Henry Schellhorn

We present a new mathematical model to explicitly capture the effects that the three restriction measures: the lockdown date and duration, social distancing and masks, and, schools and border closing, have in controlling the spread of…

Populations and Evolution · Quantitative Biology 2020-08-25 Liam Dowling Jones , Malik Magdon-Ismail , Laura Mersini-Houghton , Steven Meshnick

The death toll for Covid-19 may be reduced by dividing the population into two classes, the vulnerable and the fit, with different lockdown regimes. Instead of one reproduction number there now are four parameters. These make it possible to…

Populations and Evolution · Quantitative Biology 2020-10-05 Guus Balkema

We consider an SEIR epidemic model on a network also allowing random contacts, where recovered individuals could either recover naturally or be diagnosed. Upon diagnosis, manual contact tracing is triggered such that each infected network…

Physics and Society · Physics 2024-06-06 Dongni Zhang , Tom Britton

Testing is a crucial control mechanism in the beginning phase of an epidemic when the vaccines are not yet available. It enables the public health authority to detect and isolate the infected cases from the population, thereby limiting the…

Despite many studies on the transmission mechanism of the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it remains still challenging to efficiently reduce mortality. In this work, we apply a two-population…

Physics and Society · Physics 2021-09-14 Long Ma , Maksim Kitsak , Piet Van Mieghem

This paper studies the distribution function of the time of extinction of a subcritical epidemic, when a large enough proportion of the population has been immunized and/or the infectivity of the infectious individuals has been reduced, so…

Probability · Mathematics 2023-04-05 Anicet Mougabe-Peurkor , Ibrahima Drame , Modeste N'zi , Etienne Pardoux

This paper studies algorithmic strategies to effectively reduce the number of infections in susceptible-infected-recovered (SIR) epidemic models. We consider a Markov chain SIR model and its two instantiations in the deterministic SIR…

Optimization and Control · Mathematics 2020-11-24 Yuhao Yi , Liren Shan , Philip E. Paré , Karl H. Johansson

Mathematical models are instrumental to forecast the spread of pathogens and to evaluate the effectiveness of non-pharmaceutical measures. A plethora of optimal strategies has been recently developed to minimize either the infected peak…

Dynamical Systems · Mathematics 2021-11-11 J. Sereno , A. L. Anderson , A. Ferramosca , E. A. Hernandez-Vargas , A. H. Gonzalez

This paper studies if and to which extent COVID-19 epidemics can be controlled by authorities taking decisions on public health measures on the basis of daily reports of swab test results, active cases and total cases. A suitably simplified…

Physics and Society · Physics 2020-07-22 Francesco Casella

In times of outbreaks, an essential requirement for better monitoring is the evaluation of the number of undiagnosed infected individuals. An accurate estimate of this fraction is crucial for the assessment of the situation and the…

Populations and Evolution · Quantitative Biology 2021-03-17 Akiva B. Melka , Yoram Louzoun

Multiple-type branching processes that model the spread of infectious diseases are investigated. In these stochastic processes, the disease goes through multiple stages before it eventually disappears. We mostly focus on the critical…

Populations and Evolution · Quantitative Biology 2015-06-04 Tibor Antal , P. L. Krapivsky

Many disease models focus on characterizing the underlying transmission mechanism but make simple, possibly naive assumptions about how infections are reported. In this note, we use a simple deterministic Susceptible-Infected-Removed (SIR)…

Populations and Evolution · Quantitative Biology 2019-11-28 Sang Woo Park , Benjamin M. Bolker

The severe acute respiratory syndrome COVID-19 has been in the center of the ongoing global health crisis in 2020. The high prevalence of mild cases facilitates sub-notification outside hospital environments and the number of those who are…

Populations and Evolution · Quantitative Biology 2021-05-26 Gilberto Nakamura , Basil Grammaticos , Christophe Deroulers , Mathilde Badoual

During a pandemic, there are conflicting demands arising from public health and economic cost. Lockdowns are a common way of containing infections, but they adversely affect the economy. We study the question of how to minimise the economic…

Populations and Evolution · Quantitative Biology 2021-04-28 Joseph Samuel , Supurna Sinha

We study a susceptible-infected-recovered (SIR) epidemic model on a network of $n$ interacting subpopulations. We analyze the transient and asymptotic behavior of the infection dynamics in each node of the network. In contrast to the…

Dynamical Systems · Mathematics 2024-03-18 Martina Alutto , Leonardo Cianfanelli , Giacomo Como , Fabio Fagnani

Sample pooling consists in combining samples from multiple individuals into a single pool that is then tested using a unique test-kit. A positive test means that at least one individual within the pool is infected. Here, we propose an…

Quantitative Methods · Quantitative Biology 2021-03-18 Vincent Brault , Bastien Mallein , Jean-Francois Rupprecht

In this paper, we investigate the problem of mitigating epidemics by applying an event-triggered control strategy. We consider a susceptible-infected-removed-susceptible (SIRS) model, which builds upon the foundational SIR model by…

Systems and Control · Electrical Eng. & Systems 2023-10-17 Lichen Ding , Kazumune Hashimoto , Shigemasa Takai