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In the last year many public health decisions were based on real-time monitoring the spread of the ongoing COVID-19 pandemic. For this one often considers the reproduction number which measures the amount of secondary cases produced by a…

Applications · Statistics 2021-09-01 Jan Pablo Burgard , Stefan Heyder , Thomas Hotz , Tyll Krueger

This paper deals with the problem of estimating variables in nonlinear models for the spread of disease and its application to the COVID-19 epidemic. First unconstrained methods are revisited and they are shown to correspond to the…

Optimization and Control · Mathematics 2020-08-20 Mauricio C. de Oliveira

The basic reproduction number, $R_0$ is an important and widely used concept in the study of infectious diseases. We briefly review the recent trend of calculating the average of various $R_0$ estimates in systematic reviews aimed at…

Populations and Evolution · Quantitative Biology 2021-12-13 Pratyush K. Kollepara , Joel C. Miller

The time varying effective reproduction number is an important parameter for communication and policy decisions during an epidemic. In this paper, we present new statistical methods for estimating the reproduction number based on the…

Methodology · Statistics 2025-10-02 Hans R. Künsch , Fabio Sigrist

Reproduction numbers, like the basic reproduction number $\mathcal{R}_0$, play an important role in the analysis and application of dynamic models, including contagion models and ecological population models. One difficulty in deriving…

Populations and Evolution · Quantitative Biology 2021-05-25 Paul J. Hurtado , Cameron Richards

This is a pedagogical paper on estimating the number of people that can be infected by one infectious person during an epidemic outbreak, known as the reproduction number. Knowing the number is crucial for developing policy responses. There…

Populations and Evolution · Quantitative Biology 2020-06-30 H. Susanto , V. R. Tjahjono , A. Hasan , M. F. Kasim , N. Nuraini , E. R. M. Putri , R. Kusdiantara , H. Kurniawan

Motivated by the question of optimal vaccine allocation strategies in heterogeneous population for epidemic models, we study various properties of the \emph{effective reproduction number}. In the simplest case, given a fixed, non-negative…

Optimization and Control · Mathematics 2022-11-23 Jean-François Delmas , Dylan Dronnier , Pierre-André Zitt

Accurate epidemic forecasting requires models that account for the layered and heterogeneous nature of real social interactions. The basic reproduction number $\mathcal R_0$ calculated from models that assume homogeneous mixing or…

Physics and Society · Physics 2025-10-15 Eric Alejandro Rozan , Mario Ignacio Simoy , Sebastian Bouzat , Marcelo Nestor Kuperman

In epidemiological modelings, the spectral radius of the next generation matrix evaluated at the trivial equilibrium was considered as the basic reproduction number. Also, the global stability of the trivial equilibrium point was determined…

Populations and Evolution · Quantitative Biology 2020-06-15 Hyun Mo Yang

We propose an approximation of nonlinear renewal equations by means of ordinary differential equations. We consider the integrated state, which is absolutely continuous and satisfies a delay differential equation. By applying the…

Numerical Analysis · Mathematics 2021-03-23 Francesca Scarabel , Odo Diekmann , Rossana Vermiglio

The probability of the survival of the population of individuals of both sexes of given mature age, procreation rate and structure stability has been searched in the numerical experiment. The populations with long period of reproduction and…

Condensed Matter · Physics 2007-05-23 Kazimierz Pater

We precisely quantify the impact of statistical error in the quality of a numerical approximation to a random matrix eigendecomposition, and under mild conditions, we use this to introduce an optimal numerical tolerance for residual error…

Spectral methods include a family of algorithms related to the eigenvectors of certain data-generated matrices. In this work, we are interested in studying the geometric landscape of the eigendecomposition problem in various spectral…

Optimization and Control · Mathematics 2022-07-13 Shuang Li , Gongguo Tang , Michael B. Wakin

This work provides a geometric version of the next-generation matrix method for obtaining the basic reproduction number of an epidemiological model. We exhibit a certain correspondence between any system of ODEs and Petri nets. We observe…

Populations and Evolution · Quantitative Biology 2025-08-12 Carlos Segovia

The effective reproduction number, R(t), is a central point in the study of infectious diseases. It establishes in an explicit way the extent of an epidemic spread process in a population. The current estimation methods for the time…

Populations and Evolution · Quantitative Biology 2021-02-26 D. C. P. Jorge , J. F. Oliveira , J. G. V. Miranda , R. F. S. Andrade , S. T. R. Pinho

We consider a family of periodic SEIRS epidemic models with a fairly general incidence rate and it is shown the basic reproduction number determines the global dynamics of the models and it is a threshold parameter for persistence.…

Dynamical Systems · Mathematics 2017-04-05 Eric Ávila-Vales , Erika Rivero-Esquivel , Gerardo García-Almeida

The basic reproduction number of a networked epidemic model, denoted $R_0$, can be computed from a network's topology to quantify epidemic spread. However, disclosure of $R_0$ risks revealing sensitive information about the underlying…

Social and Information Networks · Computer Science 2025-06-23 Bo Chen , Baike She , Calvin Hawkins , Alex Benvenuti , Brandon Fallin , Philip E. Paré , Matthew Hale

Near-real time estimations of the effective reproduction number are among the most important tools to track the progression of a pandemic and to inform policy makers and the general public. However, these estimations rely on reported case…

Physics and Society · Physics 2022-07-25 Eszter Bokányi , Zsolt Vizi , Júlia Koltai , Gergely Röst , Márton Karsai

We study the multi-species replicator model with linear fitness and random fitness matrices of various classes. By means of numerical resolution of the replicator equations, we determine the survival probability of a species in terms of its…

Adaptation and Self-Organizing Systems · Physics 2007-05-23 Sebastian Bouzat , Damian Zanette

The basic reproduction number R0 is a concept which originated in population dynamics, mathematical epidemiology, and ecology and is closely related to the mean number of children in branching processes.We offer below three new…

Populations and Evolution · Quantitative Biology 2023-11-30 Florin Avram , Rim Adenane , Lasko Basnarkov , Matthew Johnston