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In placebo-controlled randomized trials, the post-randomization use of concomitant medications may be higher in the placebo arm than in the treatment arm. This may dilute the full benefits of the randomized drug as estimated by the…

In mobile health interventions aimed at behavior change and maintenance, treatments are provided in real time to manage current or impending high risk situations or promote healthy behaviors in near real time. Currently there is great…

Methodology · Statistics 2016-08-18 Audrey Boruvka , Daniel Almirall , Katie Witkiewitz , Susan A. Murphy

Stepped wedge cluster randomized trials (SWCRTs) often face challenges with potential confounding by time trends. Traditional frequentist methods can fail to provide adequate coverage of the intervention's true effect using confidence…

Methodology · Statistics 2024-02-02 Danni Wu , Hyung G. Park , Corita R. Grudzen , Keith S. Goldfeld

Causal mediation analysis aims to estimate the natural direct and indirect effects under clearly specified assumptions. Traditional mediation analysis based on Ordinary Least Squares (OLS) relies on the absence of unmeasured causes of the…

Methodology · Statistics 2017-07-07 Cedric E. Ginestet , Richard Emsley , Sabine Landau

Many epidemiological questions concern potential interventions to alter the pathways presumed to mediate an association. For example, we consider a study that investigates the benefit of interventions in young adulthood for ameliorating the…

Methodology · Statistics 2020-07-14 Margarita Moreno-Betancur , Paul Moran , Denise Becker , George C Patton , John B Carlin

Randomized controlled trials (RCTs) face inherent limitations, such as ethical or resource constraints, which lead to a limited number of study participants. To address these limitations, recent research endeavors have sought to incorporate…

Methodology · Statistics 2025-02-20 Peijin Wang , Hwanhee Hong , Kyungeun Jeon , Laine Elliott Thomas

The paper reviews methods that seek to draw causal inference from observational data and demonstrates how they can be applied to empirical problems in engineering research. It presents a framework for causal identification based on the…

Applications · Statistics 2022-11-28 Daniel J Graham

Avoiding collisions with vulnerable road users (VRUs) using sensor-based early recognition of critical situations is one of the manifold opportunities provided by the current development in the field of intelligent vehicles. As especially…

Computer Vision and Pattern Recognition · Computer Science 2018-03-12 Michael Goldhammer , Sebastian Köhler , Stefan Zernetsch , Konrad Doll , Bernhard Sick , Klaus Dietmayer

Current clinical decision support systems (CDSSs) typically base their predictions on correlation, not causation. In recent years, causal machine learning (ML) has emerged as a promising way to improve decision-making with CDSSs by offering…

Human-Computer Interaction · Computer Science 2026-04-17 Domenique Zipperling , Lukas Schmidt , Benedikt Hahn , Niklas Kühl , Steven Kimbrough

Due to the recent advancements in wearables and sensing technology, health scientists are increasingly developing mobile health (mHealth) interventions. In mHealth interventions, mobile devices are used to deliver treatment to individuals…

Machine Learning · Computer Science 2020-07-24 Peng Liao , Predrag Klasnja , Susan Murphy

High-dimensional limit theorems have been shown useful to derive tuning rules for finding the optimal scaling in random-walk Metropolis algorithms. The assumptions under which weak convergence results are proved are however restrictive: the…

Methodology · Statistics 2022-02-16 Sebastian M Schmon , Philippe Gagnon

Researchers are frequently interested in understanding the causal effect of treatment interventions. However, in some cases, the treatment of interest--readily available in a randomized controlled trial (RCT)--is either not directly…

Methodology · Statistics 2025-09-29 Lan Wen , Aaron L Sarvet

Recently, causal inference under interference has gained increasing attention in the literature. In this paper, we focus on randomized designs for estimating the total treatment effect (TTE), defined as the average difference in potential…

Methodology · Statistics 2024-08-29 Changhao Shi , Haoyu Yang , Yichen Qin , Yang Li

Causal excursion effect (CEE) characterizes the effect of an intervention under policies that deviate from the experimental policy. It is widely used to study the effect of time-varying interventions that have the potential to be frequently…

Methodology · Statistics 2024-06-14 Zhaoxi Cheng , Lauren Bell , Tianchen Qian

Sequential, multiple assignment randomized trials (SMARTs), which assist in the optimization of adaptive interventions, are growing in popularity in education and behavioral sciences. This is unsurprising, as adaptive interventions reflect…

Methodology · Statistics 2023-09-26 Timothy Lycurgus , Amy Kilbourne , Daniel Almirall

We consider how increasingly available observational data can be used to improve the design of randomized controlled trials (RCTs). We seek to design a prospective RCT, with the intent of using an Empirical Bayes estimator to shrink the…

Methodology · Statistics 2022-04-15 Evan T. R. Rosenman , Luke Miratrix

Traditional disaster analysis and modelling tools for assessing the severity of a disaster are predictive in nature. Based on the past observational data, these tools prescribe how the current input state (e.g., environmental conditions,…

Machine Learning · Computer Science 2025-09-16 Saketh Vishnubhatla , Alimohammad Beigi , Rui Heng Foo , Umang Goel , Ujun Jeong , Bohan Jiang , Adrienne Raglin , Huan Liu

A data-driven framework is proposed for online estimation of quadrotor motor efficiency via residual minimization. The problem is formulated as a constrained nonlinear optimization that minimizes trajectory residuals between measured flight…

Systems and Control · Electrical Eng. & Systems 2026-03-09 Sheng-Wen Cheng , Teng-Hu Cheng

Online experiments such as Randomised Controlled Trials (RCTs) or A/B-tests are the bread and butter of modern platforms on the web. They are conducted continuously to allow platforms to estimate the causal effect of replacing system…

Machine Learning · Computer Science 2023-04-24 Olivier Jeunen

Deep neural networks are increasingly utilized in mobility prediction tasks, yet their intricate internal workings pose challenges for interpretability, especially in comprehending how various aspects of mobility behavior affect…

Physics and Society · Physics 2024-08-02 Ye Hong , Yanan Xin , Simon Dirmeier , Fernando Perez-Cruz , Martin Raubal