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The use of Hodgkin-Huxley (HH) equations abounds in the literature, but the identifiability of the HH model parameters has not been broadly considered. Identifiability analysis addresses the question of whether it is possible to estimate…

Neurons and Cognition · Quantitative Biology 2015-11-18 Olivia J. Walch , Marisa C. Eisenberg

In this work, we consider the problem of robust parameter estimation from observational data in the context of linear structural equation models (LSEMs). LSEMs are a popular and well-studied class of models for inferring causality in the…

Machine Learning · Computer Science 2020-07-15 Karthik Abinav Sankararaman , Anand Louis , Navin Goyal

Biological processes are often modeled by ordinary differential equations with unknown parameters. The unknown parameters are usually estimated from experimental data. In some cases, due to the structure of the model, this estimation…

Symbolic Computation · Computer Science 2020-11-17 Hoon Hong , Alexey Ovchinnikov , Gleb Pogudin , Chee Yap

In this note, we propose a novel approach for a class of autonomous dynamical systems that allows, given some observations of the solutions, to identify its parameters and reconstruct the state vector. This approach relies on proving the…

Dynamical Systems · Mathematics 2024-08-22 Alicja B Kubik , Alain Rapaport , Benjamin Ivorra , Ángel M Ramos

This paper investigates parameter learning problems under deficient excitation (DE). The DE condition is a rank-deficient, and therefore, a more general evolution of the well-known persistent excitation condition. Under the DE condition, a…

Systems and Control · Electrical Eng. & Systems 2025-05-29 Ganghui Cao , Shimin Wang , Martin Guay , Jinzhi Wang , Zhisheng Duan , Marios M. Polycarpou

We propose a novel iterative algorithm for estimating a deterministic but unknown parameter vector in the presence of model uncertainties. This iterative algorithm is based on a system model where an overall noise term describes both, the…

Statistics Theory · Mathematics 2017-11-27 Oliver Lang , Michael Lunglmayr , Mario Huemer

We present a new method for statistical verification of quantitative properties over a partially unknown system with actions, utilising a parameterised model (in this work, a parametric Markov decision process) and data collected from…

Machine Learning · Computer Science 2017-07-06 Elizabeth Polgreen , Viraj Wijesuriya , Sofie Haesaert , Alessandro Abate

The observability of a dynamical system is affected by the presence of external inputs, either known (such as control actions) or unknown (disturbances). Inputs of unknown magnitude are especially detrimental for observability, and they…

Systems and Control · Electrical Eng. & Systems 2020-06-02 Nerea Martínez , Alejandro F. Villaverde

Parameter identification problems for partial differential equations are an important subclass of inverse problems. The parameter-to-state map, which maps the parameter of interest to the respective solution of the PDE or state of the…

Numerical Analysis · Mathematics 2020-02-13 Heiko Hoffmann , Anne Wald

Mixture models have been widely used in modeling of continuous observations. For the possibility to estimate the parameters of a mixture model consistently on the basis of observations from the mixture, identifiability is a necessary…

Probability · Mathematics 2014-07-02 ZiQiang Shi , TieRan Zheng , JiQing Han

Identifiability means that iterates generated by optimization algorithms are eventually confined to an identifiable set. This property is computationally useful because minimizing a nonsmooth function near a critical point reduces to…

Optimization and Control · Mathematics 2026-05-05 Hanju Wu , Yue Xie

In this paper, we give an overview of the differential algebra approach to identifiability, and then note a very simple observation about input-output equivalence and identifiability, that describes the identifiability equivalence between…

Quantitative Methods · Quantitative Biology 2019-08-20 Marisa Eisenberg

Computational models are of increasing complexity and their behavior may in particular emerge from the interaction of different parts. Studying such models becomes then more and more difficult and there is a need for methods and tools…

Neural and Evolutionary Computing · Computer Science 2015-07-27 Stéphane Doncieux , Jean Liénard , Benoît Girard , Mohamed Hamdaoui , Joël Chaskalovic

To comprehend complex systems with multiple states, it is imperative to reveal the identity of these states by system outputs. Nevertheless, the mathematical models describing these systems often exhibit nonlinearity so that render the…

Machine Learning · Computer Science 2023-07-04 Guangtao Zhang , Yiting Duan , Guanyu Pan , Qijing Chen , Huiyu Yang , Zhikun Zhang

Spurred by tremendous success in pattern matching and prediction tasks, researchers increasingly resort to machine learning to aid original scientific discovery. Given large amounts of observational data about a system, can we uncover the…

Machine Learning · Computer Science 2025-01-31 Hananeh Aliee , Fabian J. Theis , Niki Kilbertus

Differential-elimination algorithms apply a finite number of differentiations and eliminations to systems of partial differential equations. For systems that are polynomially nonlinear with rational number coefficients, they guarantee the…

Symbolic Computation · Computer Science 2024-10-17 Siyuan Deng , Michelle Hatzel , Gregory Reid , Wenqiang Yang , Wenyuan Wu

A key trait of stochastic optimizers is that multiple runs of the same optimizer in attempting to solve the same problem can produce different results. As a result, their performance is evaluated over several repeats, or runs, on the…

Machine Learning · Computer Science 2026-05-18 Moslem Noori , Elisabetta Valiante , Thomas Van Vaerenbergh , Masoud Mohseni , Ignacio Rozada

Given a small random sample of $n$-bit strings labeled by an unknown Boolean function, which properties of this function can be tested computationally efficiently? We show an equivalence between properties that are efficiently testable from…

Computational Complexity · Computer Science 2026-04-07 Cynthia Dwork , Pranay Tankala

Modern data analysis depends increasingly on estimating models via flexible high-dimensional or nonparametric machine learning methods, where the identification of structural parameters is often challenging and untestable. In linear…

Statistics Theory · Mathematics 2026-01-21 Andrii Babii , Jean-Pierre Florens

We study the problem of Out-of-Distribution (OOD) detection, that is, detecting whether a learning algorithm's output can be trusted at inference time. While a number of tests for OOD detection have been proposed in prior work, a formal…

Machine Learning · Statistics 2023-09-19 Akshayaa Magesh , Venugopal V. Veeravalli , Anirban Roy , Susmit Jha