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Topological Data Analysis (TDA) has recently gained significant attention in the field of financial prediction. However, the choice of point cloud construction methods, topological feature representations, and classification models has a…

Machine Learning · Computer Science 2024-11-22 Dazhi Huang , Pengcheng Xu , Xiaocheng Huang , Jiayi Chen

In this paper, we evaluate the contribution of different handwriting modalities to the diagnosis of Parkinson's disease. We analyse on-surface movement, in-air movement and pressure exerted on the tablet surface. Especially in-air movement…

Signal Processing · Electrical Eng. & Systems 2022-03-23 Peter Drotár , Jiří Mekyska , Zdeněk Smékal , Irena Rektorová , Lucia Masarová , Marcos Faundez-Zanuy

We introduce a very general approach to the analysis of signals from their noisy measurements from the perspective of Topological Data Analysis (TDA). While TDA has emerged as a powerful analytical tool for data with pronounced topological…

Signal Processing · Electrical Eng. & Systems 2025-07-29 Juan Manuel Miramont , Kin Aun Tan , Soumendu Sundar Mukherjee , Rémi Bardenet , Subhroshekhar Ghosh

Emerging brain network studies suggest that interactions between various distributed neuronal populations may be characterized by an organized complex topological structure. Many brain diseases are associated with altered topological…

Neurons and Cognition · Quantitative Biology 2016-03-24 Shuo Chen , F. DuBois Bowman , Yishi Xing

Parkinson's Disease (PD) is the second most common neurodegenerative disease in humans. PD is characterized by the gradual loss of dopaminergic neurons in the Substantia Nigra (SN). Counting the number of dopaminergic neurons in the SN is…

Computer Vision and Pattern Recognition · Computer Science 2023-10-16 Fatemeh Haghighi , Soumitra Ghosh , Hai Ngu , Sarah Chu , Han Lin , Mohsen Hejrati , Baris Bingol , Somaye Hashemifar

In this paper we evaluate the suitability of handwriting patterns as potential biomarkers to model Parkinson disease (PD). Although the study of PD is attracting the interest of many researchers around the world, databases to evaluate…

Computer Vision and Pattern Recognition · Computer Science 2019-03-21 R. Castrillon , A. Acien , J. R. Orozco-Arroyave , A. Morales , J. F. Vargas , R. Vera-Rodrıguez , J. Fierrez , J. Ortega-Garcia , A. Villegas

This paper presents an innovative and generic deep learning approach to monitor heart conditions from ECG signals.We focus our attention on both the detection and classification of abnormal heartbeats, known as arrhythmia. We strongly…

Machine Learning · Computer Science 2019-06-14 Meryll Dindin , Yuhei Umeda , Frederic Chazal

Parkinson's Disease (PD) medication management presents unique challenges due to heterogeneous disease progression and treatment response. Neurologists must balance symptom control with optimal dopaminergic dosing based on functional…

Machine Learning · Computer Science 2025-08-15 Ricardo Diaz-Rincon , Muxuan Liang , Adolfo Ramirez-Zamora , Benjamin Shickel

Topological Data Analysis (TDA) has emerged as a powerful tool for extracting meaningful features from complex data structures, driving significant advancements in fields such as neuroscience, biology, machine learning, and financial…

Machine Learning · Computer Science 2025-04-02 ZiXin Lin , Nur Fariha Syaqina Zulkepli

Topological data analysis (TDA) has emerged as one of the most promising techniques to reconstruct the unknown shapes of high-dimensional spaces from observed data samples. TDA, thus, yields key shape descriptors in the form of persistent…

Machine Learning · Statistics 2017-11-15 Wei Guo , Krithika Manohar , Steven L. Brunton , Ashis G. Banerjee

Parkinson's disease (PD) is a common neurodegenerative disorder that severely diminishes patients' quality of life. Its global prevalence has increased markedly in recent decades. Current diagnostic workflows are complex and heavily reliant…

Computer Vision and Pattern Recognition · Computer Science 2026-03-12 Shuai Shao , Yan Wang , Shu Jiang , Shiyuan Zhao , Di Yang , Jiangtao Wang , Yutong Bai , Jianguo Zhang

Under the banner of `Big Data', the detection and classification of structure in extremely large, high dimensional, data sets, is, one of the central statistical challenges of our times. Among the most intriguing approaches to this…

Methodology · Statistics 2022-06-08 Robert J. Adler , Sarit Agami , Pratyush Pranav

In the past few years, there are several researches on Parkinson's disease (PD) recognition using single-photon emission computed tomography (SPECT) images with deep learning (DL) approach. However, the DL model's complexity usually results…

Image and Video Processing · Electrical Eng. & Systems 2021-05-05 Theerasarn Pianpanit , Sermkiat Lolak , Phattarapong Sawangjai , Thapanun Sudhawiyangkul , Theerawit Wilaiprasitporn

Parkinson's disease (PD), the second most prevalent neurodegenerative disorder worldwide, frequently presents with early-stage speech impairments. Recent advancements in Artificial Intelligence (AI), particularly deep learning (DL), have…

Sound · Computer Science 2024-09-25 Lisanne van Gelderen , Cristian Tejedor-García

In this paper, we introduce a novel approach for diagnosis of Parkinson's Disease (PD) based on deep Echo State Networks (ESNs). The identification of PD is performed by analyzing the whole time-series collected from a tablet device during…

Machine Learning · Computer Science 2018-02-20 Claudio Gallicchio , Alessio Micheli , Luca Pedrelli

This paper deals with a complex acoustic analysis of phonation in patients with Parkinson's disease (PD) with a special focus on estimation of disease progress that is described by 7 different clinical scales ,e. g. Unified Parkinson's…

Falls are detrimental to people with Parkinson's Disease (PD) because of the potentially severe consequences to the patients' quality of life. While many studies have attempted to predict falls/non-falls, this study aimed to determine…

Applications · Statistics 2019-10-07 Sarini Abdullah , James McGree , Nicole White , Kerrie Mengersen , Graham Kerr

Modelling the progression of Degenerative Diseases (DD) is essential for detection, prevention, and treatment, yet it remains challenging due to the heterogeneity in disease trajectories among individuals. Factors such as demographics,…

Optimization and Control · Mathematics 2024-12-19 Alessandro Viani , Boris A Gutman , Emile d'Angremont , Marco Lorenzi

In this study, we executed a genomic analysis with the objective of selecting a set of genes (possibly small) that would help in the detection and classification of samples from patients affected by Parkinson Disease. We performed a…

Machine Learning · Computer Science 2016-02-24 Giancarlo Crocetti , Michael Coakley , Phil Dressner , Wanda Kellum , Tamba Lamin

Understanding how the spatial structure of blood vessel networks relates to their function in healthy and abnormal biological tissues could improve diagnosis and treatment for diseases such as cancer. New imaging techniques can generate…

Quantitative Methods · Quantitative Biology 2019-07-23 Helen M Byrne , Heather A Harrington , Ruth Muschel , Gesine Reinert , Bernadette J Stolz , Ulrike Tillmann