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We introduce a new diffuse interface model for tumour growth in the presence of a nutrient, in which we take into account mechanical effects and reversible tissue damage. The highly nonlinear PDEs system mainly consists of a Cahn-Hilliard…

Analysis of PDEs · Mathematics 2025-10-09 Giulia Cavalleri

We consider the inverse problem of parameter estimation in a diffuse interface model for tumour growth. The model consists of a fourth-order Cahn-Hilliard system and contains three phenomenological parameters: the tumour proliferation rate,…

Numerical Analysis · Mathematics 2019-05-10 Christian Kahle , Kei Fong Lam , Jonas Latz , Elisabeth Ullmann

In this work, we consider a diffuse interface model for tumour growth in the presence of a nutrient which is consumed by the tumour. The system of equations consists of a Cahn--Hilliard equation with source terms for the tumour cells and a…

Numerical Analysis · Mathematics 2022-05-09 Harald Garcke , Dennis Trautwein

In this work, we analyze a diffuse-interface model for tumor growth, subject to multiplicative white noises, posed on a bounded domain $\mathcal{O} \subset \mathbb{R}^d$, $d=2,3$. The model couples a stochastic incompressible convective…

Analysis of PDEs · Mathematics 2026-05-29 Kalpana Rawat , Kumarasamy Sakthivel

In this paper, a distributed optimal control problem is studied for a diffuse interface model of tumor growth which was proposed in [A. Hawkins-Daruud, K.G. van der Zee, J.T. Oden, Numerical simulation of a thermodynamically consistent…

Analysis of PDEs · Mathematics 2018-09-10 Pierluigi Colli , Gianni Gilardi , Elisabetta Rocca , Jürgen Sprekels

The Cahn-Hilliard equation is a fundamental model for phase separation phenomena. Its rigorous derivation from the nonlocal aggregation equation, motivated by the desire to link interacting particle systems and continuous descriptions, has…

Analysis of PDEs · Mathematics 2024-07-08 Charles Elbar , Jakub Skrzeczkowski

In the present work, we develop a comprehensive and rigorous analytical framework for a non-local phase-field model that describes tumour growth dynamics. The model is derived by coupling a non-local Cahn-Hilliard equation with a parabolic…

Analysis of PDEs · Mathematics 2025-03-14 Maurizio Grasselli , Luca Melzi , Andrea Signori

We study a nonlocal Cahn-Hilliard model for a multicomponent mixture with cross-diffusion effects and degenerate mobility. The nonlocality is described by means of a symmetric singular kernel. We define a notion of weak solution adapted to…

Analysis of PDEs · Mathematics 2026-05-22 Elisa Davoli , Greta Marino , Jan-Frederik Pietschmann

We consider the problem of the long time dynamics for a diffuse interface model for tumor growth. The model describes the growth of a tumor surrounded by host tissues in the presence of a nutrient and consists in a Cahn-Hilliard-type…

Analysis of PDEs · Mathematics 2018-10-30 Alain Miranville , Elisabetta Rocca , Giulio Schimperna

In this paper we consider two diffuse interface models for tumor growth coupling a Cahn-Hilliard type equation for the tumor phase parameter to a reaction-diffusion type equation for the nutrient. The models are distinguished by the…

Analysis of PDEs · Mathematics 2024-07-31 Filippo Riva , Elisabetta Rocca

We study a bulk-surface Cahn--Hilliard model with non-degenerate mobility and singular potentials in two dimensions. Following the ideas of the recent work by Conti, Galimberti, Gatti, and Giorgini [Calc. Var. Partial Differential…

Analysis of PDEs · Mathematics 2026-03-05 Jonas Stange

In this paper, we study an initial boundary value problem of the Cahn-Hilliard-Darcy system with a non-autonomous mass source term $S$ that models tumor growth. We first prove the existence of global weak solutions as well as the existence…

Analysis of PDEs · Mathematics 2023-07-28 Jie Jiang , Hao Wu , Songmu Zheng

We study a moving boundary problem describing the growth of nonnecrotic tumors in different regimes of vascularisation. This model consists of two decoupled Dirichlet problem, one for the rate at which nutrient is added to the tumor domain…

Analysis of PDEs · Mathematics 2010-03-05 Joachim Escher , Anca-Voichita Matioc

We investigate the Cahn-Hilliard equation with nonlinear diffusion and non-degenerate mobility modeling phase separation phenomena in complex systems (e.g., crystals and polymers). Previous results in the literature on this model relied on…

Analysis of PDEs · Mathematics 2025-10-10 Monica Conti , Stefania Gatti , Andrea Giorgini , Giulio Schimperna

We study a stochastic phase-field model for tumor growth dynamics coupling a stochastic Cahn-Hilliard equation for the tumor phase parameter with a stochastic reaction-diffusion equation governing the nutrient proportion. We prove strong…

Analysis of PDEs · Mathematics 2021-01-19 Carlo Orrieri , Elisabetta Rocca , Luca Scarpa

We study a Cahn-Hilliard-Darcy system with mass sources, which can be considered as a basic, though simplified, diffuse interface model for the evolution of tumor growth. This system is equipped with an impermeability condition for the…

Optimization and Control · Mathematics 2024-08-20 Marco Abatangelo , Cecilia Cavaterra , Maurizio Grasselli , Hao Wu

We consider a local Cahn-Hilliard-type model for tumor growth as well as a nonlocal model where, compared to the local system, the Laplacian in the equation for the chemical potential is replaced by a nonlocal operator. The latter is…

Analysis of PDEs · Mathematics 2024-02-22 Christoph Hurm , Maximilian Moser

We analyze a phase field model for tumor growth consisting of a Cahn-Hilliard-Brinkman system, ruling the evolution of the tumor mass, coupled with an advection-reaction-diffusion equation for a chemical species acting as a nutrient. The…

Analysis of PDEs · Mathematics 2023-07-26 Pierluigi Colli , Gianni Gilardi , Andrea Signori , Jürgen Sprekels

We study the Cahn-Hilliard equation with non-degenerate concentration-dependent mobility and logarithmic potential in two dimensions. We show that any weak solution is unique, exhibits propagation of uniform-in-time regularity, and…

Analysis of PDEs · Mathematics 2025-03-25 Monica Conti , Pietro Galimberti , Stefania Gatti , Andrea Giorgini

Local well-posedness is established for a highly nonlocal nonlinear diffusion-adhesion system for bounded initial values with small support. Macroscopic systems of this kind were previously obtained by the authors through upscaling in [32]…

Analysis of PDEs · Mathematics 2025-05-16 Mabel Lizzy Rajendran , Anna Zhigun