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Modeling biological networks serves as both a major goal and an effective tool of systems biology in studying mechanisms that orchestrate the activities of gene products in cells. Biological networks are context specific and dynamic in…

Molecular Networks · Quantitative Biology 2014-02-20 Ye Tian , Bai Zhang , Eric P. Hoffman , Robert Clarke , Zhen Zhang , Ie-Ming Shih , Jianhua Xuan , David M. Herrington , Yue Wang

We demonstrate a meaningful prospective power analysis for an (admittedly idealized) illustrative connectome inference task. Modeling neurons as vertices and synapses as edges in a simple random graph model, we optimize the trade-off…

Neurons and Cognition · Quantitative Biology 2011-10-13 Carey E. Priebe , Joshua T. Vogelstein , Davi Bock

Adaptive experimentation under unknown network interference requires solving two coupled problems: (i) learning the underlying dynamics of interference among units and (ii) using these dynamics to inform treatment allocation in order to…

Machine Learning · Statistics 2026-05-13 Aidan Gleich , Eric Laber , Alexander Volfovsky

Using results from neurobiology on perceptual decision making and value-based decision making, the problem of decision making between lotteries is reformulated in an abstract space where uncertain prospects are mapped to corresponding…

Neurons and Cognition · Quantitative Biology 2020-01-03 Adnan Rebei

Deciphering the underpinnings of the dynamical processes leading to information transmission, processing, and storing in the brain is a crucial challenge in neuroscience. An inspiring but speculative theoretical idea is that such dynamics…

Statistical Mechanics · Physics 2023-07-21 Guillermo B. Morales , Serena Di Santo , Miguel A. Muñoz

The specific connectivity of a neuronal network is reflected in the dynamics of the signals recorded on its nodes. The analysis of how the activity in one node predicts the behaviour of another gives the directionality in their…

Quantitative Methods · Quantitative Biology 2019-11-21 Víctor J. López-Madrona , Fernanda Matias , Claudio Mirasso , Santiago Canals , Ernesto Pereda

The graph identification problem consists of discovering the interactions among nodes in a network given their state/feature trajectories. This problem is challenging because the behavior of a node is coupled to all the other nodes by the…

Systems and Control · Electrical Eng. & Systems 2023-10-24 Eduardo Sebastian , Thai Duong , Nikolay Atanasov , Eduardo Montijano , Carlos Sagues

Neural network systems describe complex mappings that can be very difficult to understand. In this paper, we study the inverse problem of determining the input images that get mapped to specific neural network classes. Ultimately, we expect…

Computer Vision and Pattern Recognition · Computer Science 2026-03-25 Rebecca Pattichis , Sebastian Janampa , Constantinos S. Pattichis , Marios S. Pattichis

Understanding and interacting with everyday physical scenes requires rich knowledge about the structure of the world, represented either implicitly in a value or policy function, or explicitly in a transition model. Here we introduce a new…

Understanding how animals learn is a central challenge in neuroscience, with growing relevance to the development of animal- or human-aligned artificial intelligence. However, existing approaches tend to assume fixed parametric forms for…

Machine Learning · Computer Science 2026-02-06 Yuhan Helena Liu , Victor Geadah , Jonathan Pillow

Neuronal responses are conspicuously variable. We focus on one particular aspect of that variability: the precision of action potential timing. We show that for common models of noisy spike generation, elementary considerations imply that…

Disordered Systems and Neural Networks · Physics 2009-10-31 Guillermo A. Cecchi , Mariano Sigman , Jose-Manuel Alonso , Luis Martinez , Dante R. Chialvo , Marcelo O. Magnasco

Networks of neurons in some brain areas are flexible enough to encode new memories quickly. Using a standard firing rate model of recurrent networks, we develop a theory of flexible memory networks. Our main results characterize networks…

Neurons and Cognition · Quantitative Biology 2015-02-25 Carina Curto , Anda Degeratu , Vladimir Itskov

Inferring topological and geometrical information from data can offer an alternative perspective on machine learning problems. Methods from topological data analysis, e.g., persistent homology, enable us to obtain such information,…

Computer Vision and Pattern Recognition · Computer Science 2018-02-19 Christoph Hofer , Roland Kwitt , Marc Niethammer , Andreas Uhl

We study pairwise Ising models for describing the statistics of multi-neuron spike trains, using data from a simulated cortical network. We explore efficient ways of finding the optimal couplings in these models and examine their…

Quantitative Methods · Quantitative Biology 2009-05-21 Yasser Roudi , Joanna Tyrcha , John Hertz

Finding interdependency relations between (possibly multivariate) time series provides valuable knowledge about the processes that generate the signals. Information theory sets a natural framework for non-parametric measures of several…

Information Theory · Computer Science 2016-02-09 German Gomez-Herrero , Wei Wu , Kalle Rutanen , Miguel C. Soriano , Gordon Pipa , Raul Vicente

The brain's structural and functional systems, protein-protein interaction, and gene networks are examples of biological systems that share some features of complex networks, such as highly connected nodes, modularity, and small-world…

A method for nonlinear topology identification is proposed, based on the assumption that a collection of time series are generated in two steps: i) a vector autoregressive process in a latent space, and ii) a nonlinear, component-wise,…

Signal Processing · Electrical Eng. & Systems 2021-07-02 Luis Miguel Lopez-Ramos , Kevin Roy , Baltasar Beferull-Lozano

The topology of interactions in network dynamical systems fundamentally underlies their function. Accelerating technological progress creates massively available data about collective nonlinear dynamics in physical, biological, and…

Physics and Society · Physics 2018-03-28 Jose Casadiego , Mor Nitzan , Sarah Hallerberg , Marc Timme

An important problem in network analysis is predicting a node attribute using both network covariates, such as graph embedding coordinates or local subgraph counts, and conventional node covariates, such as demographic characteristics.…

Methodology · Statistics 2023-02-24 Robert Lunde , Elizaveta Levina , Ji Zhu

Many mathematical models of interacting agents assume that individual interactions scale down in proportion to the network size, ensuring that the combined input received from the network does not diverge. In theoretical neuroscience,…

Analysis of PDEs · Mathematics 2025-11-10 Cristobal Quininao , Jonathan Touboul