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With the advent of high-throughput wet lab technologies the amount of protein interaction data available publicly has increased substantially, in turn spurring a plethora of computational methods for in silico knowledge discovery from this…

Molecular Networks · Quantitative Biology 2015-05-06 Sriganesh Srihari , Hon Wai Leong

Compendium Manager is a command-line tool written in Python to automate the provisioning, launch, and evaluation of bioinformatics pipelines. Although workflow management tools such as Snakemake and Nextflow enable users to automate the…

Genomics · Quantitative Biology 2025-05-19 Richard J. Abdill , Ran Blekhman

In this paper, we propose a new mixed-integer linear programming (MILP) model ontology and a novel constraint typology of MILP formulations. MILP is a commonly used mathematical programming technique for modelling and solving real-life…

Artificial Intelligence · Computer Science 2021-03-02 Bahadorreza Ofoghi , Vicky Mak , John Yearwood

Recently, the topic of table pre-training has attracted considerable research interest. However, how to employ table pre-training to boost the performance of tabular prediction remains an open challenge. In this paper, we propose TapTap,…

Machine Learning · Computer Science 2023-05-18 Tianping Zhang , Shaowen Wang , Shuicheng Yan , Jian Li , Qian Liu

Large language models have recently surpassed specialized systems on code generation, yet their effectiveness on other code-analysis tasks remains less clear. At the same time, multi-task learning offers a way to unify diverse objectives…

Software Engineering · Computer Science 2026-03-12 Amal Akli , Maxime Cordy , Mike Papadakis , Yves Le Traon

In today's data-rich environment, recommender systems play a crucial role in decision support systems. They provide to users personalized recommendations and explanations about these recommendations. Embedding-based models, despite their…

Information Retrieval · Computer Science 2024-01-10 Ngoc Luyen Le , Marie-Hélène Abel , Philippe Gouspillou

Math Word Problems (MWP) aims to automatically solve mathematical questions given in texts. Previous studies tend to design complex models to capture additional information in the original text so as to enable the model to gain more…

Computation and Language · Computer Science 2026-01-12 Jing Xiong , Chengming Li , Min Yang , Xiping Hu , Bin Hu

Physical models of biological systems can become difficult to interpret when they have a large number of parameters. But the models themselves actually depend on (i.e. are sensitive to) only a subset of those parameters. Rigorously…

Biological Physics · Physics 2018-11-27 Chieh-Ting Hsu , Gary J. Brouhard , Paul François

Ordinary differential equation models have become a standard tool for the mechanistic description of biochemical processes. If parameters are inferred from experimental data, such mechanistic models can provide accurate predictions about…

Quantitative Methods · Quantitative Biology 2018-10-12 Fabian Fröhlich , Carolin Loos , Jan Hasenauer

Scientific research metadata is vital to ensure the validity, reusability, and cost-effectiveness of research efforts. The MEDFORD metadata language was previously introduced to simplify the process of writing and maintaining metadata for…

This study investigates the current landscape and future directions of protein foundation model research. While recent advancements have transformed protein science and engineering, the field lacks a comprehensive benchmark for fair…

Biomolecules · Quantitative Biology 2025-06-19 Zhangyang Gao , Hao Wang , Cheng Tan , Chenrui Xu , Mengdi Liu , Bozhen Hu , Linlin Chao , Xiaoming Zhang , Stan Z. Li

Behavioral Profile (BP) annotation is difficult to automate because it requires simultaneous coding across multiple linguistic dimensions. We treat BP annotation as a bundle of annotation skills rather than a single task and evaluate…

Computation and Language · Computer Science 2026-04-17 Yufeng Wu

Many machine learning tasks can benefit from external knowledge. Large knowledge graphs store such knowledge, and embedding methods can be used to distill it into ready-to-use vector representations for downstream applications. For this…

Machine Learning · Computer Science 2026-03-18 Félix Lefebvre , Gaël Varoquaux

While fine-tuning pretrained models has become common practice, these models often underperform outside their specific domains. Recently developed model merging techniques enable the direct integration of multiple models, each fine-tuned…

Computer Vision and Pattern Recognition · Computer Science 2024-10-04 Guodong Du , Junlin Lee , Jing Li , Runhua Jiang , Yifei Guo , Shuyang Yu , Hanting Liu , Sim Kuan Goh , Ho-Kin Tang , Daojing He , Min Zhang

Embedding models play a crucial role in representing and retrieving information across various NLP applications. Recent advances in large language models (LLMs) have further enhanced the performance of embedding models. While these models…

Computation and Language · Computer Science 2025-09-15 Yixuan Tang , Yi Yang

We introduce a new method for estimating the support size of an unknown distribution which provably matches the performance bounds of the state-of-the-art techniques in the area and outperforms them in practice. In particular, we present…

Machine Learning · Statistics 2019-10-22 I , Chien , Olgica Milenkovic

We describe a binding schema markup language (BSML) for describing data interchange between scientific codes. Such a facility is an important constituent of scientific problem solving environments (PSEs). BSML is designed to integrate with…

Computational Engineering, Finance, and Science · Computer Science 2007-05-23 Alex Verstak , Naren Ramakrishnan , Layne T. Watson , Jian He , Clifford A. Shaffer , Kyung Kyoon Bae , Jing Jiang , William H. Tranter , Theodore S. Rappaport

Automated generation of executable Business Process Model and Notation (BPMN) models from natural-language specifications is increasingly enabled by large language models. However, ambiguous or underspecified text can yield structurally…

Software Engineering · Computer Science 2026-04-14 Ion Matei , Praveen Kumar Menaka Sekar , Maksym Zhenirovskyy , Hon Yung Wong , Sayuri Kohmura , Shinji Hotta , Akihiro Inomata

Solutions to the Algorithm Selection Problem (ASP) in machine learning face the challenge of high computational costs associated with evaluating various algorithms' performances on a given dataset. To mitigate this cost, the meta-learning…

Machine Learning · Computer Science 2025-09-12 Cynthia Moreira Maia , Lucas B. V. de Amorim , George D. C. Cavalcanti , Rafael M. O. Cruz

Computational engineering generates knowledge through the analysis and interpretation of research data, which is produced by computer simulation. Supercomputers produce huge amounts of research data. To address a research question, a lot of…

Information Retrieval · Computer Science 2020-07-15 Björn Schembera , Dorothea Iglezakis