Related papers: A New Approach to Modeling the Microdosimetry of P…
Purpose: Recent studies suggest ultra-high dose rate (FLASH) irradiation can spare normal tissues from radiotoxicity, while efficiently controlling the tumor, and this is known as the FLASH effect. This study performed theoretical analyses…
In proton therapy both the energy, which determines the range, and the distal slope, which reflects the rate at which the protons decelerate, are of import if we are to ensure accurate dose deposition and maximum tissue sparing. This…
Motivation: Microarray experiments result in large scale data sets that require extensive mining and refining to extract useful information. We have been developing an efficient novel algorithm for nonmetric multidimensional scaling (nMDS)…
Measurements of differential cross sections for inclusive very forward jet production in proton-lead collisions as a function of jet energy are presented. The data were collected with the CMS experiment at the LHC in the laboratory…
The proton radioactivity half-lives of spherical proton emitters are investigated theoretically. The potential barriers preventing the emission of protons are determined in the quasimolecular shape path within a generalized liquid drop…
The dose distribution of a pencil beam in water consists of a core, a halo, an aura and (possibly) spray. The core is due to primary protons which suffer multiple Coulomb scattering (MCS) and slow down by multiple collisions with atomic…
Background and purpose: To investigate the possible contribution of indirect damage and damage saturation to tumour control obtained with SBRT/SRS treatments for early-stage NSCLC and brain metastases. Methods and Materials: We have…
Using the 'drift-diffusion-Langevin' equation, we have recently shown that finite-frequency shot noise in diffusive mesoscopic conductors is very sensitive to the ratio $\gamma \equiv L/\lee$ between the sample length $L$ and the…
Translating machine learning algorithms into clinical applications requires addressing challenges related to interpretability, such as accounting for the effect of confounding variables (or metadata). Confounding variables affect the…
A method is reported for a simple, yet reliable, calculation of electron inelastic mean free paths in condensed phase insulating and conducting materials, from the very low energies of hot electrons up to the high energies characteristic of…
Objective: To develop and validate an independent Monet Carlo dose calculation engine to support for software verification of treatment planning systems and quality assurance workflow. Method: GATE Monte Carlo toolkit was employed to…
Radiation damage is considered to be the major problem that still prevents imaging an individual biological molecule for structural analysis. So far, all known mapping techniques using sufficient short wave-length radiation, be it X-rays or…
Objective: Proton therapy offers an advantageous dose distribution compared to the photon therapy, since it deposits most of the energy at the end of range, namely the Bragg peak (BP). Protoacoustic technique was developed to in vivo…
Accurate dose calculation is vitally important for proton therapy. Pencil beam (PB) model-based dose calculation is fast but inaccurate due to the approximation when dealing with inhomogeneities. Monte Carlo (MC) dose calculation is the…
Background: FLASH radiation therapy (FLASH-RT) uses ultra-high dose rates to induce the FLASH effect, enhancing normal tissue sparing. In proton Bragg peak FLASH-RT, this effect is confined to high-dose regions near the target at deep…
Purpose: Cone-beam CT (CBCT) projection images provide anatomical data in real-time over several respiratory cycles, forming a comprehensive picture of tumor movement. We developed and validated a method which uses these projections to…
In carbon-ion radiotherapy, single-beam delivery each day in alternate directions has been commonly practiced for operational efficiency, taking advantage of the Bragg peak and the relative biological effectiveness (RBE) for uniform dose…
A standard dose of radioactive tracer must be delivered into the patients body to obtain high-quality Positron Emission Tomography (PET) images for diagnostic purposes, which raises the risk of radiation harm. A reduced tracer dose, on the…
In this paper we consider a physical system in which two DNA molecules braid about each other. The distance between the two molecular ends, on either side of the braid, is held at a distance much larger than supercoiling radius of the…
Target trial emulation (TTE) enables causal questions to be studied with observational data when randomized controlled trials (RCTs) are infeasible. Yet treatment-effect methods often address causal estimation, missingness, and temporal…