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Many fundamental biological processes are dependent on cellular migration. Although the mechanical mechanisms of single-cell migration are relatively well understood, those underlying migration of multiple cells adhered to each other in a…

Biological Physics · Physics 2023-07-25 Katsuhiko Sato

We derive a mixture theory-based mathematical model of the degradation of a poroelastic solid immersed in a fluid bath. The evolution of the solid's mechanical and transport properties are also modeled. The inspiration for the model is the…

Biological Physics · Physics 2019-12-16 Priyanka Patki , Francesco Costanzo

The aim of this paper is to further develop mathematical models for bleb formation in cells, including cell-membrane interactions with linker proteins. This leads to nonlinear reaction-diffusion equations on a surface coupled to fluid…

Analysis of PDEs · Mathematics 2019-12-20 Philipp Werner , Martin Burger , Jan-Frederik Pietschmann

A mechanical model and numerical method for structural membranes implied by all isosurfaces of a level-set function in a three-dimensional bulk domain are proposed. The mechanical model covers large displacements in the context of the…

Computational Engineering, Finance, and Science · Computer Science 2023-08-02 Thomas-Peter Fries , Michael W. Kaiser

Mechanochemical processes on surfaces such as the cellular cortex or epithelial sheets, play a key role in determining patterns and shape changes of biological systems. To understand the complex interplay of hydrodynamics and material flows…

Soft Condensed Matter · Physics 2023-05-04 Lucas D. Wittwer , Sebastian Aland

Cellular morphodynamics requires solving systems of coupled partial differential equations on moving bulk and surface domains, where advection-dominant transport, structure preservation, and severe mesh distortions make robust simulation…

Numerical Analysis · Mathematics 2026-01-12 Alessandro Contri , André Massing , Padmini Rangamani

The scaled boundary finite element method (SBFEM) is a relatively recent boundary element method that allows the approximation of solutions to PDEs without the need of a fundamental solution. A theoretical framework for the convergence…

Numerical Analysis · Mathematics 2021-03-23 Fleurianne Bertrand , Daniele Boffi , Gonzalo G. de Diego

In this work we propose an efficient and accurate multi-scale optical simulation algorithm by applying a numerical version of slowly varying envelope approximation in FEM. Specifically, we employ the fast iterative method to quickly compute…

Optics · Physics 2024-12-03 Fan Xiao , Jingwei Wang , Zhongfei Xiong , Yuntian Chen

A novel multi-scale finite element formulation for contact mechanics between nominally smooth but microscopically rough surfaces is herein proposed. The approach integrates the interface finite element method (FEM) for modelling interface…

Computational Engineering, Finance, and Science · Computer Science 2025-04-03 Jacopo Bonari , Maria R. Marulli , Nora Hagmeyer , Matthias Mayr , Alexander Popp , Marco Paggi

We develop a finite element method for a large deformation membrane elasticity problem on meshed surfaces using a tangential differential calculus approach that avoids the use of classical differential geometric methods. The method is also…

Numerical Analysis · Mathematics 2014-10-30 Peter Hansbo , Mats G. Larson , Fredrik Larsson

For the finite element simulation of thin soft biological tissues in dynamics, shell elements, compared to volume elements, can capture the whole tissue thickness at once, and feature larger critical time steps. However, the capabilities of…

Numerical Analysis · Mathematics 2018-01-15 Bahareh Momenan , Michel R. Labrosse

Modeling flow in geosystems with natural fault is a challenging problem due to low permeability of fault compared to its surrounding porous media. One way to predict the behavior of the flow while taking the effects of fault into account is…

Numerical Analysis · Mathematics 2020-09-11 Youguang Chen , George Biros

In this paper, we define new unfitted finite element methods for numerically approximating the solution of surface partial differential equations using bulk finite elements. The key idea is that the $n$-dimensional hypersurface, $\Gamma…

Numerical Analysis · Mathematics 2014-03-21 Klaus Deckelnick , Charles M. Elliott , Thomas Ranner

This paper presents a technique for stress and fracture analysis by using the scaled boundary finite element method (SBFEM) with quadtree mesh of high-order elements. The cells of the quadtree mesh are modelled as scaled boundary polygons…

Numerical Analysis · Mathematics 2026-03-19 Hou Man , Chongmin Song , Sundararajan Natarajan , Ean Tat Ooi , Carolin Birk

This paper presents a general and robust method for the fluid-structure interaction of membranes and shells undergoing large displacement and large added-mass effects by coupling an immersed-boundary method with a shell finite-element…

Fluid Dynamics · Physics 2023-08-15 Marin Lauber , Gabriel D. Weymouth , Georges Limbert

We present a new framework for expressing finite element methods on multiple intersecting meshes: multimesh finite element methods. The framework enables the use of separate meshes to discretize parts of a computational domain that are…

Numerical Analysis · Mathematics 2018-08-28 August Johansson , Benjamin Kehlet , Mats G. Larson , Anders Logg

The paper develops a finite element method for partial differential equations posed on hypersurfaces in $\mathbb{R}^N$, $N=2,3$. The method uses traces of bulk finite element functions on a surface embedded in a volumetric domain. The bulk…

Numerical Analysis · Mathematics 2023-07-19 Alexey Y. Chernyshenko , Maxim A. Olshanskii

Understanding the flow of deformable particles such as liquid drops, synthetic capsules and vesicles, and biological cells confined in a small channel is essential to a wide range of potential chemical and biomedical engineering…

Fluid Dynamics · Physics 2020-11-18 J. M. Lyu , Paul G. Chen , G. Boedec , M. Leonetti , M. Jaeger

We introduce a new paradigm for immersed finite element and isogeometric methods based on interpolating function spaces from an unfitted background mesh into Lagrange finite element spaces defined on a foreground mesh that captures the…

Numerical Analysis · Mathematics 2023-01-25 Jennifer E. Fromm , Nils Wunsch , Ru Xiang , Han Zhao , Kurt Maute , John A. Evans , David Kamensky

The simulation of morphogenetic problems requires the simultaneous and coupled simulation of signalling and tissue dynamics. A cellular resolution of the tissue domain is important to adequately describe the impact of cell-based events,…

Quantitative Methods · Quantitative Biology 2015-03-29 Simon Tanaka , David Sichau , Dagmar Iber