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We investigate the convergence of solutions of a recently proposed diffuse interface/phase field model for cell blebbing by means of matched asymptotic expansions. It is a biological phenomenon that increasingly attracts attention by both…

Analysis of PDEs · Mathematics 2023-02-10 Philipp Nöldner , Martin Burger , Harald Garcke

The aim of this paper is to develop suitable models for the phenomenon of cell blebbing, which allow for computational predictions of mechanical effects including the crucial interaction of the cell membrane and the actin cortex. For this…

Cell Behavior · Quantitative Biology 2021-07-15 Philipp Werner , Martin Burger , Florian Frank , Harald Garcke

We propose a robust simulation method for phospholipid membranes. It is based on a mixed three-field formulation that accounts for tangential fluidity (Boussinesq-Scriven law), bending elasticity (Canham-Helfrich model) and inextensibility.…

Numerical Analysis · Mathematics 2018-06-18 Diego S. Rodrigues , Roberto F. Ausas , Fernando Mut , Gustavo C. Buscaglia

Surfactants play an important role in various physiological and biomechanical applications. An example is the respiratory system, where pulmonary surfactants facilitate the breathing and reduce the possibility of airway blocking by lowering…

Soft Condensed Matter · Physics 2019-02-19 Farshad Roohbakhshan , Roger A. Sauer

The scaled boundary finite element method (SBFEM) has recently been employed as an efficient means to model three-dimensional structures, in particular when the geometry is provided as a voxel-based image. To this end, an octree…

Numerical Analysis · Mathematics 2023-10-31 Hauke Gravenkamp , Albert A. Saputra , Sascha Eisenträger

The paper studies a finite element method for computing transport and diffusion along evolving surfaces. The method does not require a parametrization of a surface or an extension of a PDE from a surface into a bulk outer domain. The…

Numerical Analysis · Mathematics 2014-03-04 Joerg Grande , Maxim Olshanskii , Arnold Reusken

This article addresses the research question if and how the finite cell method, an embedded domain finite element method of high order, may be used in the simulation of metal deposition to harvest its computational efficiency. This…

Numerical Analysis · Mathematics 2018-09-26 Ali Özcan , Stefan Kollmannsberger , John N. Jomo , Ernst Rank

The finite element simulation of dynamic wetting phenomena, requiring the computation of flow in a domain confined by intersecting a liquid-fluid free surface and a liquid-solid interface, with the three-phase contact line moving across the…

Computational Physics · Physics 2012-02-20 J. E. Sprittles , Y. D. Shikhmurzaev

In this paper we develop a simple finite element method for simulation of embedded layers of high permeability in a matrix of lower permeability using a basic model of Darcy flow in embedded cracks. The cracks are allowed to cut through the…

Numerical Analysis · Mathematics 2017-09-05 Erik Burman , Peter Hansbo , Mats G. Larson

We explore a new way to handle flux boundary conditions imposed on level sets. The proposed approach is a diffuse interface version of the shifted boundary method (SBM) for continuous Galerkin discretizations of conservation laws in…

Numerical Analysis · Mathematics 2022-05-11 Dmitri Kuzmin , Jan-Phillip Bäcker

A Galerkin finite element method for the membrane elasticity problem on a meshed surface is constructed by using two-dimensional elements extended into three dimensions. The membrane finite element model is established using the intrinsic…

Numerical Analysis · Mathematics 2012-03-16 Peter Hansbo , Mats G. Larson

We present a numerical method to model the dynamics of inextensible biomembranes in a quasi-Newtonian incompressible flow, which better describes hemorheology in the small vasculature. We consider a level set model for the fluid-membrane…

General Mathematics · Mathematics 2023-05-30 Aymen Laadhari , Ahmad Deeb

This study develops a polygonal cell-based smoothed finite element method (CSFEM) for two-dimensional seepage analyses in porous media, covering steady-state, transient, and free-surface problems. Wachspress interpolation on convex…

Numerical Analysis · Mathematics 2026-02-19 Yang Yang , Mingjiao Yan , Zongliang Zhang , Yinpeng Yin , Qiang Liu , You liang Li

This work is devoted to the variational derivation of a reduced model for brittle membranes in finite elasticity. The main mathematical tools we develop for our analysis are: (i) a new density result in $GSBV^{p}$ of functions satisfying a…

Analysis of PDEs · Mathematics 2022-09-23 Stefano Almi , Dario Reggiani , Francesco Solombrino

Blebs are balloon-shaped membrane protrusions that form during many physiological processes. Using computer simulation of a particle-based model for self-assembled lipid bilayers coupled to an elastic meshwork, we investigated the phase…

Biological Physics · Physics 2015-05-30 Eric J. Spangler , Cameron W. Harvey , Joel D. Revalee , P. B. Sunil Kumar , Mohamed Laradji

Several cellular activities, such as directed cell migration, are coordinated by an intricate network of biochemical reactions which lead to a polarised state of the cell, in which cellular symmetry is broken, causing the cell to have a…

Cell Behavior · Quantitative Biology 2018-09-13 Davide Cusseddu , Leah Edelstein-Keshet , John A. Mackenzie , Stéphanie Portet , Anotida Madzvamuse

We construct a cut finite element method for the membrane elasticity problem on an embedded mesh using tangential differential calculus. Both free membranes and membranes coupled to 3D elasticity are considered. The discretization comes…

Numerical Analysis · Mathematics 2016-08-24 Mirza Cenanovic , Peter Hansbo , Mats G. Larson

When modeling scientific and industrial problems, geometries are typically modeled by explicit boundary representations obtained from computer-aided design software. Unfitted (also known as embedded or immersed) finite element methods offer…

Computational Engineering, Finance, and Science · Computer Science 2024-05-24 Pere A. Martorell , Santiago Badia

Membrane computing is a well-established and successful research field which belongs to the more general area of molecular computing. Membrane computing aims at defining parallel and non-deterministic computing models, called membrane…

Distributed, Parallel, and Cluster Computing · Computer Science 2011-08-11 Bogdan Aman

The Intrinsic Surface Finite Element Method (ISFEM) was recently proposed to solve Partial Differential Equations (PDEs) on surfaces. ISFEM proceeds by writing the PDE with respect to a local coordinate system anchored to the surface and…

Numerical Analysis · Mathematics 2024-10-08 Elena Bachini , Mario Putti
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