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Many areas of science rely on simulators that implicitly encode intractable likelihood functions of complex systems. Classical statistical methods are poorly suited for these so-called likelihood-free inference (LFI) settings, especially…

Machine Learning · Statistics 2024-11-28 Niccolò Dalmasso , Luca Masserano , David Zhao , Rafael Izbicki , Ann B. Lee

We propose a general method for constructing hypothesis tests and confidence sets that have finite sample guarantees without regularity conditions. We refer to such procedures as "universal." The method is very simple and is based on a…

Statistics Theory · Mathematics 2022-10-21 Larry Wasserman , Aaditya Ramdas , Sivaraman Balakrishnan

Constructing valid confidence sets is a crucial task in statistical inference, yet traditional methods often face challenges when dealing with complex models or limited observed sample sizes. These challenges are frequently encountered in…

Certifiable, adaptive uncertainty estimates for unknown quantities are an essential ingredient of sequential decision-making algorithms. Standard approaches rely on problem-dependent concentration results and are limited to a specific…

Machine Learning · Computer Science 2023-11-09 Nicolas Emmenegger , Mojmír Mutný , Andreas Krause

In many statistical problems, the data distribution is specified through a generative process for which the likelihood function is analytically intractable, yet inference on the associated model parameters remains of primary interest. We…

Methodology · Statistics 2026-04-01 Haoyu Jiang , Yuexi Wang , Yun Yang

Parametric statistical models that are implicitly defined in terms of a stochastic data generating process are used in a wide range of scientific disciplines because they enable accurate modeling. However, learning the parameters from…

Machine Learning · Statistics 2018-10-24 Traiko Dinev , Michael U. Gutmann

The classical likelihood ratio test (LRT) based on the asymptotic chi-squared distribution of the log likelihood is one of the fundamental tools of statistical inference. A recent universal LRT approach based on sample splitting provides…

Methodology · Statistics 2022-11-22 Robin Dunn , Aaditya Ramdas , Sivaraman Balakrishnan , Larry Wasserman

Probabilistic classifiers output confidence scores along with their predictions, and these confidence scores should be calibrated, i.e., they should reflect the reliability of the prediction. Confidence scores that minimize standard metrics…

We present a universal framework for constructing confidence sets based on sequential likelihood mixing. Building upon classical results from sequential analysis, we provide a unifying perspective on several recent lines of work, and…

Machine Learning · Statistics 2025-02-21 Johannes Kirschner , Andreas Krause , Michele Meziu , Mojmir Mutny

Complex scientific models where the likelihood cannot be evaluated present a challenge for statistical inference. Over the past two decades, a wide range of algorithms have been proposed for learning parameters in computationally feasible…

Computation · Statistics 2021-12-16 Aden Forrow , Ruth E. Baker

Confidence estimation infers a probability for whether each model output is correct or not. While predicting such binary correctness is sensible for tasks with exact answers, free-form generation tasks are often more nuanced, with output…

Computation and Language · Computer Science 2026-01-14 Chi-Yang Hsu , Alexander Braylan , Yiheng Su , Matthew Lease , Omar Alonso

As hypothesis generation becomes increasingly automated, a new bottleneck has emerged: hypothesis assessment. Modern systems can surface thousands of statistical relationships-correlations, trends, causal links-but offer little guidance on…

Machine Learning · Computer Science 2025-06-05 Yue Gong , Raul Castro Fernandez

Multi-messenger observations of binary neutron star mergers offer a promising path towards resolution of the Hubble constant ($H_0$) tension, provided their constraints are shown to be free from systematics such as the Malmquist bias. In…

Cosmology and Nongalactic Astrophysics · Physics 2021-11-03 Francesca Gerardi , Stephen M. Feeney , Justin Alsing

An important problem in statistics is the construction of confidence regions for unknown parameters. In most cases, asymptotic distribution theory is used to construct confidence regions, so any coverage probability claims only hold…

Statistics Theory · Mathematics 2014-10-28 Ryan Martin

Increasingly complex generative models are being used across disciplines as they allow for realistic characterization of data, but a common difficulty with them is the prohibitively large computational cost to evaluate the likelihood…

Computation · Statistics 2017-03-06 Michael U. Gutmann , Ritabrata Dutta , Samuel Kaski , Jukka Corander

Bayesian inference is a principled framework for dealing with uncertainty. The practitioner can perform an initial assumption for the physical phenomenon they want to model (prior belief), collect some data and then adjust the initial…

Machine Learning · Computer Science 2020-11-10 Vasileios Gkolemis , Michael Gutmann

Bayesian Likelihood-Free Inference (LFI) approaches allow to obtain posterior distributions for stochastic models with intractable likelihood, by relying on model simulations. In Approximate Bayesian Computation (ABC), a popular LFI method,…

Methodology · Statistics 2022-02-08 Lorenzo Pacchiardi , Ritabrata Dutta

As large language models (LLMs) are increasingly deployed in critical decision-making systems, the lack of reliable methods to measure their uncertainty presents a fundamental trustworthiness risk. We introduce a normalized confidence score…

Machine Learning · Computer Science 2026-03-10 Xie Xiaohu , Liu Xiaohu , Yao Benjamin

We consider the problem of parametric statistical inference when likelihood computations are prohibitively expensive but sampling from the model is possible. Several so-called likelihood-free methods have been developed to perform inference…

Machine Learning · Statistics 2020-09-14 Owen Thomas , Ritabrata Dutta , Jukka Corander , Samuel Kaski , Michael U. Gutmann

High-fidelity simulators that connect theoretical models with observations are indispensable tools in many sciences. When coupled with machine learning, a simulator makes it possible to infer the parameters of a theoretical model directly…

Methodology · Statistics 2023-11-03 Ali Al Kadhim , Harrison B. Prosper , Olivia F. Prosper
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