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Likelihood-free inference is concerned with the estimation of the parameters of a non-differentiable stochastic simulator that best reproduce real observations. In the absence of a likelihood function, most of the existing inference methods…

Machine Learning · Statistics 2019-01-03 Arthur Pesah , Antoine Wehenkel , Gilles Louppe

Multivariate linear regressions are widely used statistical tools in many applications to model the associations between multiple related responses and a set of predictors. To infer such associations, it is often of interest to test the…

Statistics Theory · Mathematics 2019-10-07 Yinqiu He , Tiefeng Jiang , Jiyang Wen , Gongjun Xu

The arrival of AI techniques in computations, with the potential for hallucinations and non-robustness, has made trustworthiness of algorithms a focal point. However, trustworthiness of the many classical approaches are not well understood.…

Optimization and Control · Mathematics 2023-12-19 Alexander Bastounis , Felipe Cucker , Anders C. Hansen

In many fields of science, generalized likelihood ratio tests are established tools for statistical inference. At the same time, it has become increasingly common that a simulator (or generative model) is used to describe complex processes…

Applications · Statistics 2016-03-21 Kyle Cranmer , Juan Pavez , Gilles Louppe

The design of optimal test statistics is a key task in frequentist statistics and for a number of scenarios optimal test statistics such as the profile-likelihood ratio are known. By turning this argument around we can find the profile…

Methodology · Statistics 2022-03-25 Lukas Heinrich

Assuming we have iid observations from two unknown probability density functions (pdfs), $p$ and $q$, the likelihood-ratio estimation (LRE) is an elegant approach to compare the two pdfs only by relying on the available data. In this paper,…

Machine Learning · Statistics 2024-02-02 Alejandro de la Concha , Nicolas Vayatis , Argyris Kalogeratos

Likelihood-free inference (LFI) has been successfully applied to state-space models, where the likelihood of observations is not available but synthetic observations generated by a black-box simulator can be used for inference instead.…

Machine Learning · Computer Science 2023-02-21 Alexander Aushev , Thong Tran , Henri Pesonen , Andrew Howes , Samuel Kaski

This paper studies the identification, estimation, and hypothesis testing problem in complete and incomplete economic models with testable assumptions. Testable assumptions ($A$) give strong and interpretable empirical content to the models…

Econometrics · Economics 2022-03-11 Moyu Liao

Likelihood-free methods are useful for parameter estimation of complex models with intractable likelihood functions for which it is easy to simulate data. Such models are prevalent in many disciplines including genetics, biology, ecology…

Methodology · Statistics 2022-03-29 Christopher Drovandi , David T Frazier

We consider the use of machine learning for hypothesis testing with an emphasis on target detection. Classical model-based solutions rely on comparing likelihoods. These are sensitive to imperfect models and are often computationally…

Machine Learning · Computer Science 2022-06-14 Tzvi Diskin , Uri Okun , Ami Wiesel

Mechanistic dynamic models of biochemical networks such as Ordinary Differential Equations (ODEs) contain unknown parameters like the reaction rate constants and the initial concentrations of the compounds. The large number of parameters as…

Data Analysis, Statistics and Probability · Physics 2017-08-14 Clemens Kreutz , Andreas Raue , Jens Timmer

In a linear regression model of fixed dimension $p \leq n$, we construct confidence regions for the unknown parameter vector based on the Lasso estimator that uniformly and exactly hold the prescribed in finite samples as well as in an…

Statistics Theory · Mathematics 2018-10-08 Karl Ewald , Ulrike Schneider

Every student in statistics or data science learns early on that when the sample size largely exceeds the number of variables, fitting a logistic model produces estimates that are approximately unbiased. Every student also learns that there…

Statistics Theory · Mathematics 2022-06-08 Pragya Sur , Emmanuel J. Candes

Limit distributions of likelihood ratio statistics are well-known to be discontinuous in the presence of nuisance parameters at the boundary of the parameter space, which lead to size distortions when standard critical values are used for…

Econometrics · Economics 2025-07-29 Giuseppe Cavaliere , Adam McCloskey , Rasmus S. Pedersen , Anders Rahbek

The area under a receiver operating characteristic curve (AUC) is a useful tool to assess the performance of continuous-scale diagnostic tests on binary classification. In this article, we propose an empirical likelihood (EL) method to…

Methodology · Statistics 2022-05-05 Chul Moon , Xinlei Wang , Johan Lim

The construction of confidence intervals for the mean of a bounded random variable is a classical problem in statistics with numerous applications in machine learning and virtually all scientific fields. In particular, obtaining the…

Machine Learning · Computer Science 2025-11-12 Václav Voráček , Francesco Orabona

This paper introduces a first implementation of a novel likelihood-ratio-based approach for constructing confidence intervals for neural networks. Our method, called DeepLR, offers several qualitative advantages: most notably, the ability…

Machine Learning · Statistics 2023-08-07 Laurens Sluijterman , Eric Cator , Tom Heskes

This study aims to evaluate the performance of power in the likelihood ratio test for changepoint detection by bootstrap sampling, and proposes a hypothesis test based on bootstrapped confidence interval lengths. Assuming i.i.d normally…

Methodology · Statistics 2020-11-10 Ryan Chen , Javier Cabrera

Level set estimation (LSE), the problem of identifying the set of input points where a function takes value above (or below) a given threshold, is important in practical applications. When the function is expensive-to-evaluate and…

Machine Learning · Statistics 2024-12-02 Yu Inatsu , Shion Takeno , Kentaro Kutsukake , Ichiro Takeuchi

Approximate Bayesian computing is a powerful likelihood-free method that has grown increasingly popular since early applications in population genetics. However, complications arise in the theoretical justification for Bayesian inference…

Computation · Statistics 2018-12-03 Suzanne Thornton , Wentao Li , Min-ge Xie