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Parkinsons Disease (PD) is a neurodegenerative disorder resulting in motor deficits due to advancing degeneration of dopaminergic neurons. PD patients report experiencing tremor, rigidity, visual impairment, bradykinesia, and several…

Computer Vision and Pattern Recognition · Computer Science 2023-04-05 Krish Desai

Understanding the spatiotemporal dynamics of disease progression in relation to transcriptomic profiles provides key insights into complex conditions such as Alzheimer disease. To enable such investigations, STARmap PLUS technology offers…

Applications · Statistics 2026-04-28 Zitian Wu , Susmita Datta , Arkaprava Roy

Recent research has focused on designing neural samplers that amortize the process of sampling from unnormalized densities. However, despite significant advancements, they still fall short of the state-of-the-art MCMC approach, Parallel…

Parkinson's disease (PD) is a neurological disorder requiring early and accurate diagnosis for effective management. Machine learning (ML) has emerged as a powerful tool to enhance PD classification and diagnostic accuracy, particularly by…

Resting-state EEG (rs-EEG) has been demonstrated to aid in Parkinson's disease (PD) diagnosis. In particular, the power spectral density (PSD) of low-frequency bands ({\delta} and {\theta}) and high-frequency bands ({\alpha} and \b{eta})…

Signal Processing · Electrical Eng. & Systems 2023-03-03 Anna Kurbatskaya , Alberto Jaramillo-Jimenez , John Fredy Ochoa-Gomez , Kolbjørn Brønnick , Alvaro Fernandez-Quilez

The detection of Alzheimer's disease (AD) from spontaneous speech has attracted increasing attention while the sparsity of training data remains an important issue. This paper handles the issue by knowledge transfer, specifically from both…

Computation and Language · Computer Science 2024-04-02 Ziyun Cui , Wen Wu , Wei-Qiang Zhang , Ji Wu , Chao Zhang

Speech-based algorithms have gained interest for the management of behavioral health conditions such as depression. We explore a speech-based transfer learning approach that uses a lightweight encoder and that transfers only the encoder…

Audio and Speech Processing · Electrical Eng. & Systems 2024-12-30 Amir Harati , Elizabeth Shriberg , Tomasz Rutowski , Piotr Chlebek , Yang Lu , Ricardo Oliveira

Parkinsons Disease (PD) is a progressive neurological disorder that primarily affects motor functions and can lead to mild cognitive impairment (MCI) and dementia in its advanced stages. With approximately 10 million people diagnosed…

Image and Video Processing · Electrical Eng. & Systems 2025-05-02 Abu Saleh Musa Miah , taro Suzuki , Jungpil Shin

In this paper we propose an efficient deep learning encoder-decoder network for performing Harmonic-Percussive Source Separation (HPSS). It is shown that we are able to greatly reduce the number of model trainable parameters by using a…

Sound · Computer Science 2019-07-31 Carlos Lordelo , Emmanouil Benetos , Simon Dixon , Sven Ahlbäck

Atypical Parkinsonian Disorders (APD), also known as Parkinson-plus syndrome, are a group of neurodegenerative diseases that include progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). In the early stages, overlapping…

Computer Vision and Pattern Recognition · Computer Science 2026-04-16 Mengyu Li , Ingibjörg Kristjánsdóttir , Thilo van Eimeren , Kathrin Giehl , Lotta M. Ellingsen , the ASAP Neuroimaging Initiative

Sparse principal component analysis (PCA) is an important technique for dimensionality reduction of high-dimensional data. However, most existing sparse PCA algorithms are based on non-convex optimization, which provide little guarantee on…

Methodology · Statistics 2019-11-20 Yixuan Qiu , Jing Lei , Kathryn Roeder

In this work we suggest a statistical mechanics approach to the classification of high-dimensional data according to a binary label. We propose an algorithm whose aim is twofold: First it learns a classifier from a relatively small number…

Statistical Mechanics · Physics 2009-07-22 Andrea Pagnani , Francesca Tria , Martin Weigt

Data-driven methods have recently made great progress in the discovery of partial differential equations (PDEs) from spatial-temporal data. However, several challenges remain to be solved, including sparse noisy data, incomplete candidate…

Computational Physics · Physics 2021-09-28 Hao Xu , Dongxiao Zhang , Junsheng Zeng

The most effective dimensionality reduction procedures produce interpretable features from the raw input space while also providing good performance for downstream supervised learning tasks. For many methods, this requires optimizing one or…

Machine Learning · Computer Science 2023-02-22 Leland Barnard , Farwa Ali , Hugo Botha , David T. Jones

Background: Parkinson's disease (PD) is a prevalent long-term neurodegenerative disease. Though the diagnostic criteria of PD are relatively well defined, the current medical imaging diagnostic procedures are expertise-demanding, and thus…

Quantitative Methods · Quantitative Biology 2019-02-27 Jiahang Xu , Fangyang Jiao , Yechong Huang , Xinzhe Luo , Qian Xu , Ling Li , Xueling Liu , Chuantao Zuo , Ping Wu , Xiahai Zhuang

This paper considers a representation learning strategy to model speech signals from patients with Parkinson's disease and cleft lip and palate. In particular, it compares different parametrized representation types such as wideband and…

Audio and Speech Processing · Electrical Eng. & Systems 2022-09-20 Gabriel Figueiredo Miller , Juan Camilo Vásquez-Correa , Juan Rafael Orozco-Arroyave , Elmar Nöth

Parkinson's disease (PD) presents a growing global challenge, affecting over 10 million individuals, with prevalence expected to double by 2040. Early diagnosis remains difficult due to the late emergence of motor symptoms and limitations…

Machine Learning · Computer Science 2025-10-21 Arianna Francesconi , Donato Cappetta , Fabio Rebecchi , Paolo Soda , Valerio Guarrasi , Rosa Sicilia

Recently, progressive learning has shown its capacity to improve speech quality and speech intelligibility when it is combined with deep neural network (DNN) and long short-term memory (LSTM) based monaural speech enhancement algorithms,…

Sound · Computer Science 2020-01-14 Andong Li , Minmin Yuan , Chengshi Zheng , Xiaodong Li

Researchers are exploring novel computational paradigms such as sparse coding and neuromorphic computing to bridge the efficiency gap between the human brain and conventional computers in complex tasks. A key area of focus is neuromorphic…

Audio and Speech Processing · Electrical Eng. & Systems 2025-09-01 Soufiyan Bahadi , Eric Plourde , Jean Rouat

Modern ASR systems are typically trained on large-scale pseudo-labeled, in-the-wild data spanning multiple domains. While such heterogeneous data benefit generalist models designed for broad deployment, they pose challenges for specialist…

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