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Automatic detection and segmentation of cells and nuclei in microscopy images is important for many biological applications. Recent successful learning-based approaches include per-pixel cell segmentation with subsequent pixel grouping, or…

Computer Vision and Pattern Recognition · Computer Science 2018-11-09 Uwe Schmidt , Martin Weigert , Coleman Broaddus , Gene Myers

Medical image segmentation typically necessitates a large and precisely annotated dataset. However, obtaining pixel-wise annotation is a labor-intensive task that requires significant effort from domain experts, making it challenging to…

Computer Vision and Pattern Recognition · Computer Science 2023-08-01 Heng Cai , Lei Qi , Qian Yu , Yinghuan Shi , Yang Gao

Semantic segmentation of neuronal structures in 3D high-resolution fluorescence microscopy imaging of the human brain cortex can take advantage of bidimensional CNNs, which yield good results in neuron localization but lead to inaccurate…

Image and Video Processing · Electrical Eng. & Systems 2020-09-03 Filippo Maria Castelli , Matteo Roffilli , Giacomo Mazzamuto , Irene Costantini , Ludovico Silvestri , Francesco Saverio Pavone

Most of the current state-of-the-art methods for tumor segmentation are based on machine learning models trained on manually segmented images. This type of training data is particularly costly, as manual delineation of tumors is not only…

Computer Vision and Pattern Recognition · Computer Science 2019-08-21 Pawel Mlynarski , Hervé Delingette , Antonio Criminisi , Nicholas Ayache

Modeling the 3D structures of cells and tissues is crucial in biology. Sequential cross-sectional images from electron microscopy provide high-resolution intracellular structure information. The segmentation of complex cell structures…

Quantitative Methods · Quantitative Biology 2025-02-14 Jin Kousaka , Atsuko H. Iwane , Yuichi Togashi

Robust and accurate nuclei centroid detection is important for the understanding of biological structures in fluorescence microscopy images. Existing automated nuclei localization methods face three main challenges: (1) Most of object…

Image and Video Processing · Electrical Eng. & Systems 2021-11-05 Liming Wu , Shuo Han , Alain Chen , Paul Salama , Kenneth W. Dunn , Edward J. Delp

For many biological image segmentation tasks, including topological knowledge, such as the nesting of classes, can greatly improve results. However, most `out-of-the-box' CNN models are still blind to such prior information. In this paper,…

Computer Vision and Pattern Recognition · Computer Science 2018-08-22 Marie Piraud , Anjany Sekuboyina , Bjoern H. Menze

Since labeling medical image data is a costly and labor-intensive process, active learning has gained much popularity in the medical image segmentation domain in recent years. A variety of active learning strategies have been proposed in…

Computer Vision and Pattern Recognition · Computer Science 2022-07-05 Josafat-Mattias Burmeister , Marcel Fernandez Rosas , Johannes Hagemann , Jonas Kordt , Jasper Blum , Simon Shabo , Benjamin Bergner , Christoph Lippert

Deep learning-based segmentation techniques have shown remarkable performance in brain segmentation, yet their success hinges on the availability of extensive labeled training data. Acquiring such vast datasets, however, poses a significant…

Computer Vision and Pattern Recognition · Computer Science 2024-07-18 Jihoon Cho , Suhyun Ahn , Beomju Kim , Hyungjoon Bae , Xiaofeng Liu , Fangxu Xing , Kyungeun Lee , Georges Elfakhri , Van Wedeen , Jonghye Woo , Jinah Park

In the cancer diagnosis pipeline, digital pathology plays an instrumental role in the identification, staging, and grading of malignant areas on biopsy tissue specimens. High resolution histology images are subject to high variance in…

Image and Video Processing · Electrical Eng. & Systems 2023-08-17 Vasileios Magoulianitis , Catherine A. Alexander , C. -C. Jay Kuo

Deep convolutional neural networks (CNNs) are state-of-the-art for semantic image segmentation, but typically require many labeled training samples. Obtaining 3D segmentations of medical images for supervised training is difficult and labor…

Computer Vision and Pattern Recognition · Computer Science 2019-07-29 Zhenlin Xu , Marc Niethammer

AI-assisted surgeries have drawn the attention of the medical image research community due to their real-world impact on improving surgery success rates. For image-guided surgeries, such as Cochlear Implants (CIs), accurate object…

Image and Video Processing · Electrical Eng. & Systems 2023-02-17 Yike Zhang , Jack Noble

The throughput of electron microscopes has increased significantly in recent years, enabling detailed analysis of cell morphology and ultrastructure. Analysis of neural circuits at single-synapse resolution remains the flagship target of…

Computer Vision and Pattern Recognition · Computer Science 2019-08-07 Constantin Pape , Alex Matskevych , Adrian Wolny , Julian Hennies , Giula Mizzon , Marion Louveaux , Jacob Musser , Alexis Maizel , Detlev Arendt , Anna Kreshuk

Medical image segmentation has significantly benefitted thanks to deep learning architectures. Furthermore, semi-supervised learning (SSL) has recently been a growing trend for improving a model's overall performance by leveraging abundant…

Image and Video Processing · Electrical Eng. & Systems 2021-10-05 S. M. Kamrul Hasan , Cristian A. Linte

Segmentation and classification of cell nuclei in histopathology images using deep neural networks (DNNs) can save pathologists' time for diagnosing various diseases, including cancers, by automating cell counting and morphometric…

Computer Vision and Pattern Recognition · Computer Science 2023-10-06 Amruta Parulekar , Utkarsh Kanwat , Ravi Kant Gupta , Medha Chippa , Thomas Jacob , Tripti Bameta , Swapnil Rane , Amit Sethi

In recent years, computer vision has transformed fields such as medical imaging, object recognition, and geospatial analytics. One of the fundamental tasks in computer vision is semantic image segmentation, which is vital for precise object…

Computer Vision and Pattern Recognition · Computer Science 2023-11-09 Dinar Sharafutdinov , Stanislav Kuskov , Saian Protasov , Alexey Voropaev

Introduction: The present study on the development and evaluation of an automated brain tumor segmentation technique based on deep learning using the 3D U-Net model. Objectives: The objective is to leverage state-of-the-art convolutional…

Image and Video Processing · Electrical Eng. & Systems 2024-04-10 Suman Sourabh , Murugappan Valliappan , Narayana Darapaneni , Anwesh R P

Cell detection and segmentation is fundamental for all downstream analysis of digital pathology images. However, obtaining the pixel-level ground truth for single cell segmentation is extremely labor intensive. To overcome this challenge,…

Computer Vision and Pattern Recognition · Computer Science 2019-10-29 Alireza Chamanzar , Yao Nie

Medical image segmentation has been significantly advanced by deep learning (DL) techniques, though the data scarcity inherent in medical applications poses a great challenge to DL-based segmentation methods. Self-supervised learning offers…

Computer Vision and Pattern Recognition · Computer Science 2024-02-13 Binyan Hu , A. K. Qin

Accurate detection and segmentation of cell nuclei in volumetric (3D) fluorescence microscopy datasets is an important step in many biomedical research projects. Although many automated methods for these tasks exist, they often struggle for…

Computer Vision and Pattern Recognition · Computer Science 2020-06-16 Martin Weigert , Uwe Schmidt , Robert Haase , Ko Sugawara , Gene Myers