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Multi-valued networks provide a simple yet expressive qualitative state based modelling approach for biological systems. In this paper we develop an abstraction theory for asynchronous multi-valued network models that allows the state space…

Distributed, Parallel, and Cluster Computing · Computer Science 2011-08-18 L. Jason Steggles

The Abstraction and Reasoning Corpus (ARC-AGI) presents a formidable challenge for AI systems. Despite the typically low performance on ARC, the deep learning paradigm remains the most effective known strategy for generating skillful…

Artificial Intelligence · Computer Science 2025-11-03 Jack Cole , Mohamed Osman

Chemical reactions occur in energy, environmental, biological, and many other natural systems, and the inference of the reaction networks is essential to understand and design the chemical processes in engineering and life sciences. Yet,…

Molecular Networks · Quantitative Biology 2021-01-22 Weiqi Ji , Sili Deng

We study the problem of finite-horizon probabilistic invariance for discrete-time Markov processes over general (uncountable) state spaces. We compute discrete-time, finite-state Markov chains as formal abstractions of general Markov…

Systems and Control · Computer Science 2015-07-03 Sadegh Esmaeil Zadeh Soudjani , Alessandro Abate , Rupak Majumdar

Across many disciplines, chemical reaction networks (CRNs) are an established population model defined as a system of coupled nonlinear ordinary differential equations. In many applications, for example, in systems biology and epidemiology,…

Systems and Control · Electrical Eng. & Systems 2023-01-23 Kim G. Larsen , Daniele Toller , Mirco Tribastone , Max Tschaikowski , Andrea Vandin

Abstraction (in its various forms) is a powerful established technique in model-checking; still, when unbounded data-structures are concerned, it cannot always cope with divergence phenomena in a satisfactory way. Acceleration is an…

Logic in Computer Science · Computer Science 2013-10-04 Francesco Alberti , Silvio Ghilardi , Natasha Sharygina

Formal methods have enabled breakthroughs in many fields, such as in hardware verification, machine learning and biological systems. The key object of interest in systems biology, synthetic biology, and molecular programming is chemical…

Emerging Technologies · Computer Science 2020-08-11 Marko Vasic , David Soloveichik , Sarfraz Khurshid

Neural abstractions have been recently introduced as formal approximations of complex, nonlinear dynamical models. They comprise a neural ODE and a certified upper bound on the error between the abstract neural network and the concrete…

Logic in Computer Science · Computer Science 2023-10-03 Alec Edwards , Mirco Giacobbe , Alessandro Abate

Computational techniques are required for narrowing down the vast space of possibilities to plausible prebiotic scenarios, since precise information on the molecular composition, the dominant reaction chemistry, and the conditions for that…

Molecular Networks · Quantitative Biology 2018-02-07 Jakob L. Andersen , Christoph Flamm , Daniel Merkle , Peter F. Stadler

Embedding computation in biochemical environments incompatible with traditional electronics is expected to have wide-ranging impact in synthetic biology, medicine, nanofabrication and other fields. Natural biochemical systems are typically…

Machine Learning · Computer Science 2022-06-15 Marko Vasic , Cameron Chalk , Austin Luchsinger , Sarfraz Khurshid , David Soloveichik

Designing controllers to satisfy temporal requirements has proven to be challenging for dynamical systems that are affected by uncertainty. This is mainly due to the states evolving in a continuous uncountable space, the stochastic…

Systems and Control · Electrical Eng. & Systems 2024-07-08 Birgit C. van Huijgevoort , Ruohan Wang , Sadegh Soudjani , Sofie Haesaert

Abstraction is crucial for effective sequential decision making in domains with large state spaces. In this work, we propose an information bottleneck method for learning approximate bisimulations, a type of state abstraction. We use a deep…

Machine Learning · Computer Science 2021-01-12 Ondrej Biza , Robert Platt , Jan-Willem van de Meent , Lawson L. S. Wong

The Chemical Reaction Network (CRN) is a well-studied model that describes the interaction of molecules in well-mixed solutions. In 2014, Qian and Winfree [22] proposed the abstract surface chemical reaction network model (sCRN), which…

Computational Complexity · Computer Science 2024-06-14 Yi-Xuan Lee , Ho-Lin Chen

Chemical Reaction Neural Networks (CRNNs) have emerged as an interpretable machine learning framework for discovering reaction kinetics directly from data, while strictly adhering to the Arrhenius and mass action laws. However, standard…

Chemical Physics · Physics 2026-05-15 Benjamin C. Koenig , Sili Deng

Inferring chemical reaction networks (CRN) from concentration time series is a challenge encouragedby the growing availability of quantitative temporal data at the cellular level. This motivates thedesign of algorithms to infer the…

Quantitative Methods · Quantitative Biology 2023-02-09 Julien Martinelli , Jeremy Grignard , Sylvain Soliman , Annabelle Ballesta , François Fages

Multi-valued network models are an important qualitative modelling approach used widely by the biological community. In this paper we consider developing an abstraction theory for multi-valued network models that allows the state space of a…

Computational Engineering, Finance, and Science · Computer Science 2010-11-03 Richard Banks , L. Jason Steggles

Learning abstractions directly from data is a core challenge in robotics. Humans naturally operate at an abstract level, reasoning over high-level subgoals while delegating execution to low-level motor skills -- an ability that enables…

Robotics · Computer Science 2026-03-23 Abhiroop Ajith , Constantinos Chamzas

Analysis of Markov Decision Processes (MDP) is often hindered by state space explosion. Abstraction is a well-established technique in model checking to mitigate this issue. This paper presents a novel lazy abstraction method for MDP…

Logic in Computer Science · Computer Science 2024-06-04 Dániel Szekeres , Kristóf Marussy , István Majzik

The abstract visual reasoning ability in human intelligence benefits discovering underlying rules in the novel environment. Raven's Progressive Matrix (RPM) is a classic test to realize such ability in machine intelligence by selecting from…

Artificial Intelligence · Computer Science 2023-07-18 Fan Shi , Bin Li , Xiangyang Xue

Automated machine learning (AutoML) streamlines the creation of ML models. While most methods select the "best" model based on predictive quality, it's crucial to acknowledge other aspects, such as interpretability and resource consumption.…

Machine Learning · Computer Science 2023-12-21 Raphael Fischer , Amal Saadallah