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The development of X-ray Free Electron Lasers (XFELs) has opened numerous opportunities to probe atomic structure and ultrafast dynamics of various materials. Single Particle Imaging (SPI) with XFELs enables the investigation of biological…
A major challenge in X-ray computed tomography (CT) is reducing radiation dose while maintaining high quality of reconstructed images. To reduce the radiation dose, one can reduce the number of projection views (sparse-view CT); however, it…
Introduction: Altered neurometabolism is an important pathological mechanism in many neurological diseases and brain cancer, which can be mapped non-invasively by Magnetic Resonance Spectroscopic Imaging (MRSI). Advanced MRSI using…
Scanning Transmission Electron Microscopy (STEM) enables the observation of atomic arrangements at sub-angstrom resolution, allowing for atomically resolved analysis of the physical and chemical properties of materials. However, due to the…
Single Photon Emission Computed Tomography (SPECT) is one of the nuclear medicine imaging modalities used for functional analysis of animal and human organs. Gamma rays emitted from the scanned body are filtered with collimators and…
Ultrafast ultrasound (US) revolutionized biomedical imaging with its capability of acquiring full-view frames at over 1 kHz, unlocking breakthrough modalities such as shear-wave elastography and functional US neuroimaging. Yet, it suffers…
High quality scanning transmission electron microscopy (STEM) data acquisition and analysis has become increasingly important due to the commercial demand for investigating the properties of complex materials such as battery cathodes;…
Ultra low radiation dose in X-ray Computed Tomography (CT) is an important clinical objective in order to minimize the risk of carcinogenesis. Compressed Sensing (CS) enables significant reductions in radiation dose to be achieved by…
Speed-of-sound is a biomechanical property for quantitative tissue differentiation, with great potential as a new ultrasound-based image modality. A conventional ultrasound array transducer can be used together with an acoustic mirror, or…
The development of fast and accurate image reconstruction algorithms is a central aspect of computed tomography. In this paper, we investigate this issue for the sparse data problem in photoacoustic tomography (PAT). We develop a direct and…
In this paper, we present a novel Bayesian approach for estimating spectral and range profiles from single-photon Lidar waveforms associated with single surfaces in the photon-limited regime. In contrast to classical multispectral Lidar…
A central problem in neuroscience is reconstructing neuronal circuits on the synapse level. Due to a wide range of scales in brain architecture such reconstruction requires imaging that is both high-resolution and high-throughput. Existing…
We report the first experimental test of an analytic image reconstruction algorithm for optical tomography with large data sets. Using a continuous-wave optical tomography system with 10^8 source-detector pairs, we demonstrate the…
The random equivalent sampling (RES) is a well-known sampling technique that can be used to capture a high-speed repetitive waveform with low sampling rate. In this paper, the feasibility of spectrum-blind multiband signal reconstruction…
Deep learning has emerged as a technique of choice for rapid feature extraction across imaging disciplines, allowing rapid conversion of the data streams to spatial or spatiotemporal arrays of features of interest. However, applications of…
Scanning transmission electron microscopy (STEM) is an extremely versatile method for studying materials on the atomic scale. Many STEM experiments are supported or validated with electron scattering simulations. However, using the…
The image-based rendering approach using Shearlet Transform (ST) is one of the state-of-the-art Densely-Sampled Light Field (DSLF) reconstruction methods. It reconstructs Epipolar-Plane Images (EPIs) in image domain via an iterative…
Scanning Transmission Electron Microscopy (STEM) coupled with Electron Energy Loss Spectroscopy (EELS) presents a powerful platform for detailed material characterization via rich imaging and spectroscopic data. Modern electron microscopes…
Here we apply hyperspectral bright field imaging to collect computed tomographic images with excellent energy resolution (800 eV), applying it for the first time to map the distribution of stain in a fixed biological sample through its…
Accurate multi-slice reconstruction from limited measurement data is crucial to speed up the acquisition process in medical and scientific imaging. However, it remains challenging due to the ill-posed nature of the problem and the high…