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Big science initiatives are trying to reconstruct and model the brain by attempting to simulate brain tissue at larger scales and with increasingly more biological detail than previously thought possible. The exponential growth of parallel…

Performance · Computer Science 2020-06-25 Francesco Cremonesi , Georg Hager , Gerhard Wellein , Felix Schürmann

The interaction of condensed phase systems with external electric fields is crucial in myriad processes in nature and technology ranging from the field-directed motion of cells (galvanotaxis), to energy storage and conversion systems…

Chemical Physics · Physics 2024-09-25 Kit Joll , Philipp Schienbein , Kevin M. Rosso , Jochen Blumberger

ExaScale systems will be a key driver for simulations that are essential for advance of science and economic growth. We aim to present a new concept of microprocessor for floating-point computations useful for being a basic building block…

Hardware Architecture · Computer Science 2019-02-19 Elisardo Antelo

The transition from standard generative AI to \emph{reasoning-centric architectures}, exemplified by models capable of extensive Chain-of-Thought~(CoT) processing, marks a fundamental paradigm shift in system requirements. Unlike…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-05-20 Moiz Arif , Avinash Maurya , Sudharshan Vazhkudai , Bogdan Nicolae

Non-orthogonal multiple access (NOMA) is an interesting technology that enables massive connectivity as required in future 5G and 6G networks. While purely linear processing already achieves good performance in NOMA systems, in certain…

Signal Processing · Electrical Eng. & Systems 2022-06-14 Daniel Schäufele , Guillermo Marcus , Nikolaus Binder , Matthias Mehlhose , Alexander Keller , Sławomir Stańczak

Recently, hybrid architectures using accelerators like GPGPUs or the Cell processor have gained much interest in the HPC community. The RapidMind Multi-Core Development Platform is a programming environment that allows generating code which…

Performance · Computer Science 2010-02-19 Iris Christadler , Volker Weinberg

Computational chemistry allows researchers to experiment in sillico: by running a computer simulations of a biological or chemical processes of interest. Molecular dynamics with molecular mechanics model of interactions simulates N-body…

Distributed, Parallel, and Cluster Computing · Computer Science 2014-03-03 Jana Pazúriková

Massive off-chip accesses in GPUs are the main performance bottleneck, and we divided these accesses into three types: (1) Write, (2) Data-Read, and (3) Read-Only. Besides, We find that many writes are duplicate, and the duplication can be…

Hardware Architecture · Computer Science 2024-08-20 Wei Zhao , Dan Feng , Wei Tong , Xueliang Wei , Bing Wu

Emerging multimodal LLMs (MLLMs) exhibit strong cross-modality perception and reasoning capabilities and hold great potential for various applications at edge. However, MLLMs typically consist of a compute-intensive modality encoder and a…

Hardware Architecture · Computer Science 2025-05-19 Kangbo Bai , Le Ye , Ru Huang , Tianyu Jia

GROMACS is a de-facto standard for classical Molecular Dynamics (MD). The rise of AI-driven interatomic potentials that pursue near-quantum accuracy at MD throughput now poses a significant challenge: embedding neural-network inference into…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-04-09 Luca Pennati , Andong Hu , Ivy Peng , Lukas Müllender , Stefano Markidis

Electrocardiogram (ECG) interpretation is essential for diagnosing a wide range of cardiac abnormalities. While deep learning has shown strong potential for automating ECG classification, many existing models rely on large, computationally…

In this paper, we develop an in-memory analog computing (IMAC) architecture realizing both synaptic behavior and activation functions within non-volatile memory arrays. Spin-orbit torque magnetoresistive random-access memory (SOT-MRAM)…

Hardware Architecture · Computer Science 2021-09-15 Mohammed Elbtity , Abhishek Singh , Brendan Reidy , Xiaochen Guo , Ramtin Zand

The rapid evolution of Large Language Models (LLMs) towards long-context reasoning and sparse architectures has pushed memory requirements far beyond the capacity of individual device HBM. While emerging supernode architectures offer…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-02-04 Fangxin Liu , Qinghua Zhang , Hanjing Shen , Zhibo Liang , Li Jiang , Haibing Guan , Chong Bao , Xuefeng Jin

Convolutional neural networks have recently achieved significant breakthroughs in various image classification tasks. However, they are computationally expensive,which can make their feasible mplementation on embedded and low-power devices…

Machine Learning · Computer Science 2018-08-02 Mir Khan , Heikki Huttunen , Jani Boutellier

RUMD is a general purpose, high-performance molecular dynamics (MD) simulation package running on graphical processing units (GPU's). RUMD addresses the challenge of utilizing the many-core nature of modern GPU hardware when simulating…

The discoveries in this paper show that Intelligence Processing Units (IPUs) offer a viable accelerator alternative to GPUs for machine learning (ML) applications within the fields of materials science and battery research. We investigate…

Machine Learning · Computer Science 2024-04-23 Hieu Le , Zhenhua He , Mai Le , Dhruva K. Chakravorty , Lisa M. Perez , Akhil Chilumuru , Yan Yao , Jiefu Chen

We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for…

Other Condensed Matter · Physics 2008-09-10 J. A. van Meel , A. Arnold , D. Frenkel , S. F. Portegies Zwart , R. G. Belleman

Non-volatile memory (NVM) has the potential to disrupt the boundary between memory and storage, including the abstractions that manage this boundary. Researchers comparing the speed, durability, and abstractions of hybrid systems with DRAM,…

Programming Languages · Computer Science 2018-08-02 Shoaib Akram , Jennifer B. Sartor , Kathryn S. McKinley , Lieven Eeckhout

Molecular dynamics (MD) is a powerful tool for exploring the behavior of atomistic systems, but its reliance on sequential numerical integration limits simulation efficiency. We present a novel neural network architecture, MDtrajNet, and a…

Chemical Physics · Physics 2026-03-17 Fuchun Ge , Yuxinxin Chen , Pavlo O. Dral

Molecular dynamics (MD) simulation is a powerful computational tool to study the behavior of macromolecular systems. But many simulations of this field are limited in spatial or temporal scale by the available computational resource. In…

Computational Physics · Physics 2010-01-22 Ji Xu , Ying Ren , Wei Ge , Xiang Yu , Xiaozhen Yang , Jinghai Li