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Simulation speed matters for neuroscientific research: this includes not only how quickly the simulated model time of a large-scale spiking neuronal network progresses, but also how long it takes to instantiate the network model in computer…

In recommendation systems, practitioners observed that increase in the number of embedding tables and their sizes often leads to significant improvement in model performances. Given this and the business importance of these models to major…

Machine Learning · Computer Science 2020-10-26 Jie Amy Yang , Jianyu Huang , Jongsoo Park , Ping Tak Peter Tang , Andrew Tulloch

Molecular dynamics simulations are a cornerstone in science, allowing to investigate from the system's thermodynamics to analyse intricate molecular interactions. In general, to create extended molecular trajectories can be a…

Computational Physics · Physics 2022-06-22 Ludwig Winkler , Klaus-Robert Müller , Huziel E. Sauceda

In drug discovery, molecular dynamics (MD) simulation for protein-ligand binding provides a powerful tool for predicting binding affinities, estimating transport properties, and exploring pocket sites. There has been a long history of…

Machine learning models have achieved remarkable success in various real-world applications such as data science, computer vision, and natural language processing. However, model training in machine learning requires large-scale data sets…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-05-02 Xidong Wu , Preston Brazzle , Stephen Cahoon

Efficient simulation of complex plasma dynamics is crucial for advancing fusion energy research. Particle-in-Cell (PIC) Monte Carlo (MC) simulations provide insights into plasma behavior, including turbulence and confinement, which are…

Neural network potentials (NNPs) are rapidly changing the landscape of state-of-the-art molecular dynamics (MD) simulations. To make full use of this development, the community needs flexible, easy-to-use interfaces firmly integrated with…

Computational Physics · Physics 2026-04-24 Lukas Müllender , Berk Hess , Erik Lindahl

Compute in-memory (CIM) is a promising technique that minimizes data transport, the primary performance bottleneck and energy cost of most data intensive applications. This has found wide-spread adoption in accelerating neural networks for…

Signal Processing · Electrical Eng. & Systems 2021-02-16 Brian Crafton , Samuel Spetalnick , Arijit Raychowdhury

Running language models in the browser presents a unique opportunity to build efficient, private, and portable AI applications, but requires contending with constrained memory availability and heterogeneous hardware targets. To realize this…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-05-21 Reese Levine , Rithik Sharma , Nikhil Jain , Abhijit Ramesh , Zheyuan Chen , Neha Abbas , James Contini , Tyler Sorensen

The emergence of large-scale, sparse, multimodal, and agentic AI models has coincided with a shift in hardware toward supernode architectures that integrate hundreds to thousands of accelerators with ultra-low-latency interconnects and…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-03-05 Xin Zhang , Beilei Sun , Teng Su , Qinghua Zhang , Chong Bao , Lei Chen , Xuefeng Jin

The ever-increasing computation complexity of fast-growing Deep Neural Networks (DNNs) has requested new computing paradigms to overcome the memory wall in conventional Von Neumann computing architectures. The emerging Computing-In-Memory…

Hardware Architecture · Computer Science 2021-07-21 Kaining Zhou , Yangshuo He , Rui Xiao , Kejie Huang

High-performance computing, together with a neural network model trained from data generated with first-principles methods, has greatly boosted applications of \textit{ab initio} molecular dynamics in terms of spatial and temporal scales on…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-01-06 Zhuoqiang Guo , Denghui Lu , Yujin Yan , Siyu Hu , Rongrong Liu , Guangming Tan , Ninghui Sun , Wanrun Jiang , Lijun Liu , Yixiao Chen , Linfeng Zhang , Mohan Chen , Han Wang , Weile Jia

Modern graphics processing units (GPUs) provide impressive computing resources, which can be accessed conveniently through the CUDA programming interface. We describe how GPUs can be used to considerably speed up molecular dynamics (MD)…

Computational Physics · Physics 2011-04-08 Peter H. Colberg , Felix Höfling

The complexity of biological systems and processes, spanning molecular to macroscopic scales, necessitates the use of multiscale simulations to get a comprehensive understanding. Quantum mechanics/molecular mechanics (QM/MM) molecular…

Density functionals at the level of the Generalized Gradient Approximation (GGA) and a plane-wave basis set are widely used today to perform ab initio molecular dynamics (AIMD) simulations. Going up in the ladder of accuracy of density…

Computational Physics · Physics 2021-10-18 Sagarmoy Mandal , Ritama Kar , Tobias Kloeffel , Bernd Meyer , Nisanth N. Nair

Machine Learning (ML) functions are becoming ubiquitous in latency- and privacy-sensitive IoT applications, prompting a shift toward near-sensor processing at the extreme edge and the consequent increasing adoption of Parallel Ultra-Low…

Hardware Architecture · Computer Science 2022-11-15 Enrico Tabanelli , Giuseppe Tagliavini , Luca Benini

Deployment of modern TinyML tasks on small battery-constrained IoT devices requires high computational energy efficiency. Analog In-Memory Computing (IMC) using non-volatile memory (NVM) promises major efficiency improvements in deep neural…

Hardware Architecture · Computer Science 2022-01-05 Angelo Garofalo , Gianmarco Ottavi , Francesco Conti , Geethan Karunaratne , Irem Boybat , Luca Benini , Davide Rossi

Ab initio Born-Oppenheimer molecular dynamics (AIMD) is a valuable method for simulating physico-chemical processes of complex systems, including reactive systems, and for training machine learning models and force fields. Speed and…

Diffusion models have recently gained state of the art performance on many image generation tasks. However, most models require significant computational resources to achieve this. This becomes apparent in the application of medical image…

Computer Vision and Pattern Recognition · Computer Science 2025-04-16 Karan Jain , Mohammad Nayeem Teli

With an ever-growing number of parameters defining increasingly complex networks, Deep Learning has led to several breakthroughs surpassing human performance. As a result, data movement for these millions of model parameters causes a…

Neural and Evolutionary Computing · Computer Science 2023-04-12 Christopher Wolters , Brady Taylor , Edward Hanson , Xiaoxuan Yang , Ulf Schlichtmann , Yiran Chen