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Large genomic datasets are now created through numerous activities, including recreational genealogical investigations, biomedical research, and clinical care. At the same time, genomic data has become valuable for reuse beyond their…

Cryptography and Security · Computer Science 2021-12-28 Rajagopal Venkatesaramani , Zhiyu Wan , Bradley A. Malin , Yevgeniy Vorobeychik

DNA sequencing is becoming increasingly commonplace, both in medical and direct-to-consumer settings. To promote discovery, collected genomic data is often de-identified and shared, either in public repositories, such as OpenSNP, or with…

Machine Learning · Computer Science 2022-12-21 Rajagopal Venkatesaramani , Bradley A. Malin , Yevgeniy Vorobeychik

Genome sequencing technology has advanced at a rapid pace and it is now possible to generate highly-detailed genotypes inexpensively. The collection and analysis of such data has the potential to support various applications, including…

Cryptography and Security · Computer Science 2015-06-18 Muhammad Naveed , Erman Ayday , Ellen W. Clayton , Jacques Fellay , Carl A. Gunter , Jean-Pierre Hubaux , Bradley A. Malin , XiaoFeng Wang

The collection and sharing of genomic data are becoming increasingly commonplace in research, clinical, and direct-to-consumer settings. The computational protocols typically adopted to protect individual privacy include sharing summary…

Cryptography and Security · Computer Science 2023-02-06 Rajagopal Venkatesaramani , Zhiyu Wan , Bradley A. Malin , Yevgeniy Vorobeychik

Rapid advances in human genomics are enabling researchers to gain a better understanding of the role of the genome in our health and well-being, stimulating hope for more effective and cost efficient healthcare. However, this also prompts a…

Cryptography and Security · Computer Science 2018-08-20 Alexandros Mittos , Bradley Malin , Emiliano De Cristofaro

With the randomization approach, sensitive data items of records are randomized to protect privacy of individuals while allowing the distribution information to be reconstructed for data analysis. In this paper, we distinguish between…

Databases · Computer Science 2012-02-16 Ke Wang , Chao Han , Ada Waichee Fu

As genomic research has grown increasingly popular in recent years, dataset sharing has remained limited due to privacy concerns. This limitation hinders the reproducibility and validation of research outcomes, both of which are essential…

Cryptography and Security · Computer Science 2025-04-02 Yuzhou Jiang , Tianxi Ji , Erman Ayday

This study investigates embedding reconstruction attacks in large language models (LLMs) applied to genomic sequences, with a specific focus on how fine-tuning affects vulnerability to these attacks. Building upon Pan et al.'s seminal work…

Machine Learning · Computer Science 2025-11-12 Reem Al-Saidi , Erman Ayday , Ziad Kobti

The cost of DNA sequencing has resulted in a surge of genetic data being utilised to improve scientific research, clinical procedures, and healthcare delivery in recent years. Since the human genome can uniquely identify an individual, this…

Cryptography and Security · Computer Science 2022-02-11 Sara Jafarbeiki , Raj Gaire , Amin Sakzad , Shabnam Kasra Kermanshahi , Ron Steinfeld

In deep neural networks for facial recognition, feature vectors are numerical representations that capture the unique features of a given face. While it is known that a version of the original face can be recovered via "feature…

Cryptography and Security · Computer Science 2022-02-14 Emily Wenger , Francesca Falzon , Josephine Passananti , Haitao Zheng , Ben Y. Zhao

Generative models are subject to overfitting and thus may potentially leak sensitive information from the training data. In this work. we investigate the privacy risks that can potentially arise from the use of generative adversarial…

Cryptography and Security · Computer Science 2024-04-02 Abdallah Alshantti , Adil Rasheed , Frank Westad

Genomic foundation models trained on DNA sequences have demonstrated remarkable capabilities across diverse biological tasks, from variant effect prediction to genome design. These models are typically trained on massive, publicly sourced…

Genomics · Quantitative Biology 2026-03-31 Charalampos Koilakos , Ioannis Mouratidis , Ilias Georgakopoulos-Soares

The ability to share social network data at the level of individual connections is beneficial to science: not only for reproducing results, but also for researchers who may wish to use it for purposes not foreseen by the data releaser.…

Social and Information Networks · Computer Science 2020-09-22 Daniele Romanini , Sune Lehmann , Mikko Kivelä

Current techniques in sequencing a genome allow a service provider (e.g. a sequencing company) to have full access to the genome information, and thus the privacy of individuals regarding their lifetime secret is violated. In this paper, we…

Genomics · Quantitative Biology 2018-11-28 Ali Gholami , Mohammad Ali Maddah-Ali , Seyed Abolfazl Motahari

The data revolution holds significant promise for the health sector. Vast amounts of data collected from individuals will be transformed into knowledge, AI models, predictive systems, and best practices. One area of health that stands to…

Cryptography and Security · Computer Science 2024-07-15 Zahra Rahmani , Nahal Shahini , Nadav Gat , Zebin Yun , Yuzhou Jiang , Ofir Farchy , Yaniv Harel , Vipin Chaudhary , Mahmood Sharif , Erman Ayday

Portable genome sequencing technology is revolutionizing genomic research by providing a faster, more flexible method of sequencing DNA and RNA [1, 2]. The unprecedented shift from bulky stand-alone benchtop equipment confined in a…

Cryptography and Security · Computer Science 2024-07-18 Carson Stillman , Jonathan E. Bravo , Christina Boucher , Sara Rampazzi

Novel technologies in genomics allow creating data in exascale dimension with relatively minor effort of human and laboratory and thus monetary resources compared to capabilities only a decade ago. While the availability of this data…

Distributed, Parallel, and Cluster Computing · Computer Science 2015-11-10 Sandra Gesing , Thomas Richard Connor , Ian Taylor

Networks are important storage data structures now used to store personal information of individuals around the globe. With the advent of personal genome sequencing, networks are going to be used to store personal genomic sequencing of…

Social and Information Networks · Computer Science 2017-08-22 Komal Batool , Muaz A. Niazi

Federated learning has been proposed as a privacy-preserving machine learning framework that enables multiple clients to collaborate without sharing raw data. However, client privacy protection is not guaranteed by design in this framework.…

Cryptography and Security · Computer Science 2022-10-17 Kai Yue , Richeng Jin , Chau-Wai Wong , Dror Baron , Huaiyu Dai

We linked names and contact information to publicly available profiles in the Personal Genome Project. These profiles contain medical and genomic information, including details about medications, procedures and diseases, and demographic…

Computers and Society · Computer Science 2013-04-30 Latanya Sweeney , Akua Abu , Julia Winn
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