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Gene-gene interactions have long been recognized to be fundamentally important to understand genetic causes of complex disease traits. At present, identifying gene-gene interactions from genome-wide case-control studies is computationally…

Genomics · Quantitative Biology 2010-01-29 Xiang Wan , Can Yang , Qiang Yang , Hong Xue , Xiaodan Fan , Nelson L. S. Tang , Weichuan Yu

Gene finding is the task of identifying the locations of coding sequences within the vast amount of genetic code contained in the genome. With an ever increasing quantity of raw genome sequences, gene finding is an important avenue towards…

Genomics · Quantitative Biology 2025-05-07 Frederikke I. Marin , Dennis Pultz , Wouter Boomsma

To better understand DNA's 3D folding in cell nuclei, researchers developed chromosome capture methods such as Hi-C that measure the contact frequencies between all DNA segment pairs across the genome. As Hi-C data sets often are massive,…

Biological Physics · Physics 2023-11-14 Anton Holmgren , Dolores Bernenko , Ludvig Lizana

Deep neural networks (DNNs) have made tremendous progress in the past ten years and have been applied in various critical applications. However, recent studies have shown that deep neural networks are vulnerable to backdoor attacks. By…

Cryptography and Security · Computer Science 2023-05-19 Xinrui Liu , Yajie Wang , Yu-an Tan , Kefan Qiu , Yuanzhang Li

Significant advancements have recently been made in large language models represented by GPT models. Users frequently have multi-round private conversations with cloud-hosted GPT models for task optimization. Yet, this operational paradigm…

Cryptography and Security · Computer Science 2024-10-08 Junjie Chu , Zeyang Sha , Michael Backes , Yang Zhang

Membership inference attacks (MIA) try to detect if data samples were used to train a neural network model, e.g. to detect copyright abuses. We show that models with higher dimensional input and output are more vulnerable to MIA, and…

Machine Learning · Computer Science 2021-08-19 Avital Shafran , Shmuel Peleg , Yedid Hoshen

Recent advances in synthetic data generation (SDG) have been hailed as a solution to the difficult problem of sharing sensitive data while protecting privacy. SDG aims to learn statistical properties of real data in order to generate…

Machine Learning · Computer Science 2024-05-10 Meenatchi Sundaram Muthu Selva Annamalai , Andrea Gadotti , Luc Rocher

Semantic communication has emerged as a promising paradigm for enhancing communication efficiency in sixth-generation (6G) networks. However, the broadcast nature of wireless channels makes SemCom systems vulnerable to eavesdropping, which…

Information Theory · Computer Science 2025-04-01 Shunpu Tang , Yuhao Chen , Qianqian Yang , Ruichen Zhang , Dusit Niyato , Zhiguo Shi

The rapid growth in digital data forms the basis for a wide range of new services and research, e.g, large-scale medical studies. At the same time, increasingly restrictive privacy concerns and laws are leading to significant overhead in…

Cryptography and Security · Computer Science 2021-09-06 Bernardo A. Huberman , Tad Hogg

Federated learning enables collaborative machine learning while preserving data privacy. However, the rise of federated unlearning, designed to allow clients to erase their data from the global model, introduces new privacy concerns.…

Machine Learning · Computer Science 2025-07-15 Bocheng Ju , Junchao Fan , Jiaqi Liu , Xiaolin Chang

The COVID-19 crisis has demonstrated the potential of cutting-edge genomics research. However, privacy of these sensitive pieces of information is an area of significant concern for genomics researchers. The current security models makes it…

Cryptography and Security · Computer Science 2022-04-15 David Reddick , Justin Presley , F. Alex Feltus , Susmit Shannigrahi

In this paper, we introduce ACE, a consent-embedded searchable encryption scheme. ACE enables dynamic consent management by supporting the physical deletion of associated data at the time of consent revocation. This ensures instant real…

Cryptography and Security · Computer Science 2023-07-25 Sara Jafarbeiki , Amin Sakzad , Ron Steinfeld , Shabnam Kasra Kermanshahi , Chandra Thapa , Yuki Kume

Federated Learning (FL) offers a promising framework for collaboratively training machine learning models across decentralized genomic datasets without direct data sharing. While this approach preserves data locality, it remains susceptible…

Cryptography and Security · Computer Science 2025-05-13 Chetan Pathade , Shubham Patil

Motivation: Molecular interaction networks summarize complex biological processes as graphs, whose structure is informative of biological function at multiple scales. Simultaneously, omics technologies measure the variation or activity of…

Quantitative Methods · Quantitative Biology 2020-12-24 Ramin Hasibi , Tom Michoel

Biometric-based authentication systems are getting broadly adopted in many areas. However, these systems do not allow participating users to influence the way their data is used. Furthermore, the data may leak and can be misused without the…

Computer Vision and Pattern Recognition · Computer Science 2025-09-25 Lubos Mjachky , Ivan Homoliak

\ac{fl} proposed a distributed \ac{ml} framework where every distributed worker owns a complete copy of global model and their own data. The training is occurred locally, which assures no direct transmission of training data. However, the…

Cryptography and Security · Computer Science 2021-11-08 Jia Qian , Hiba Nassar , Lars Kai Hansen

Low-cost, high-throughput DNA and RNA sequencing (HTS) data is the backbone of the life sciences. Genome sequencing is now becoming a part of Predictive, Preventive, Personalized, and Participatory (termed 'P4') medicine. All genomic data…

Text-to-image generation models have recently attracted unprecedented attention as they unlatch imaginative applications in all areas of life. However, developing such models requires huge amounts of data that might contain…

Cryptography and Security · Computer Science 2022-10-04 Yixin Wu , Ning Yu , Zheng Li , Michael Backes , Yang Zhang

Regenerating codes are a class of codes for distributed storage networks that provide reliability and availability of data, and also perform efficient node repair. Another important aspect of a distributed storage network is its security.…

Information Theory · Computer Science 2015-03-19 Nihar B. Shah , K. V. Rashmi , P. Vijay Kumar

This paper presents a portable, privacy-preserving, in-browser platform for the reproducible assessment of mutational signature detection methods from sparse sequencing data generated by targeted gene panels. The platform aims to address…

Genomics · Quantitative Biology 2023-06-05 Aaron Ge , Tongwu Zhang , Clara Bodelon , Montserrat Garcia-Closas , Jonas Almeida , Jeya Balasubramanian
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