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Estimating causal quantities traditionally relies on bespoke estimators tailored to specific assumptions. Recently proposed Causal Foundation Models (CFMs) promise a more unified approach by amortising causal discovery and inference in a…

Granger causality has been employed to investigate causality relations between components of stationary multiple time series. We generalize this concept by developing statistical inference for local Granger causality for multivariate…

Methodology · Statistics 2025-08-12 Yan Liu , Masanobu Taniguchi , Hernando Ombao

Human brains exhibit highly organized multiscale neurophysiological dynamics. Understanding those dynamic changes and the neuronal networks involved is critical for understanding how the brain functions in health and disease. Functional…

Neurons and Cognition · Quantitative Biology 2024-09-09 Manuel Morante , Kristian Frølich , Naveed ur Rehman

Learning domain-invariant semantic representations is crucial for achieving domain generalization (DG), where a model is required to perform well on unseen target domains. One critical challenge is that standard training often results in…

Computer Vision and Pattern Recognition · Computer Science 2024-03-14 Liang Chen , Yong Zhang , Yibing Song , Zhen Zhang , Lingqiao Liu

We exploit altered patterns in brain functional connectivity as features for automatic discriminative analysis of neuropsychiatric patients. Deep learning methods have been introduced to functional network classification only very recently…

Machine Learning · Computer Science 2020-04-27 Chun-Ren Phang , Chee-Ming Ting , Fuad Noman , Hernando Ombao

Understanding causal relationships in time series is fundamental to many domains, including neuroscience, economics, and behavioral science. Granger causality is one of the well-known techniques for inferring causality in time series.…

Artificial Intelligence · Computer Science 2025-08-04 Chakattrai Sookkongwaree , Tattep Lakmuang , Chainarong Amornbunchornvej

To make effective decisions, it is important to have a thorough understanding of the causal relationships among actions, environments, and outcomes. This review aims to surface three crucial aspects of decision-making through a causal lens:…

Machine Learning · Statistics 2026-04-22 Lin Ge , Hengrui Cai , Runzhe Wan , Yang Xu , Rui Song

Understanding the dynamics of functional brain connectivity patterns using noninvasive neuroimaging techniques is an important focus in human neuroscience. Vector autoregressive (VAR) processes and Granger causality analysis (GCA) have been…

Applications · Statistics 2022-09-16 Jingjing Fan , Kevin Sitek , Bharath Chandrasekaran , Abhra Sarkar

Diagnosis of major depressive disorder (MDD) primarily relies on the patient's self-reported symptoms and a clinical evaluation. Effective connectivity (EC) from resting-state functional magnetic resonance imaging (rs-fMRI) analysis can…

Neurons and Cognition · Quantitative Biology 2024-01-01 Peishan Dai , Yun Shi , Tong Xiong , Xiaoyan Zhou , Shenghui Liao , Zhongchao Huang , Xiaoping Yi , Bihong T. Chen

Causal networks are useful in a wide variety of applications, from medical diagnosis to root-cause analysis in manufacturing. In practice, however, causal networks are often incomplete with missing causal relations. This paper presents a…

Artificial Intelligence · Computer Science 2024-07-15 Utkarshani Jaimini , Cory Henson , Amit P. Sheth

Complex dynamical systems are prevalent in many scientific disciplines. In the analysis of such systems two aspects are of particular interest: 1) the temporal patterns along which they evolve and 2) the underlying causal mechanisms.…

Methodology · Statistics 2022-05-31 Nicolas-Domenic Reiter , Andreas Gerhardus , Jakob Runge

Brain development during adolescence is marked by substantial changes in brain structure and function, leading to a stable network topology in adulthood. However, most prior work has examined the data through the lens of brain areas…

Quantitative Methods · Quantitative Biology 2016-12-26 Shi Gu , Muzhi Yang , John D. Medaglia , Ruben C. Gur , Raquel E. Gur , Theodore D. Satterthwaite , Danielle S. Bassett

Graph Neural Networks (GNNs) have emerged as powerful representation learning tools for capturing complex dependencies within diverse graph-structured data. Despite their success in a wide range of graph mining tasks, GNNs have raised…

Machine Learning · Computer Science 2024-06-19 Wenzhao Jiang , Hao Liu , Hui Xiong

Objective: In recent years, the functional connectivity of the human brain has been studied with graph theoretical tools. One such approach is community detection which is fundamental for uncovering the localized networks. Existing methods…

Signal Processing · Electrical Eng. & Systems 2022-09-27 Abdullah Karaaslanli , Meiby Ortiz-Bouza , Tamanna T. K. Munia , Selin Aviyente

The relationship between brain structure and function has been probed using a variety of approaches, but how the underlying structural connectivity of the human brain drives behavior is far from understood. To investigate the effect of…

Neurons and Cognition · Quantitative Biology 2018-11-15 Kanika Bansal , John D. Medaglia , Danielle S. Bassett , Jean M. Vettel , Sarah F. Muldoon

Functional connectivity is a key approach to investigate oscillatory activities of the brain that provides important insights on the underlying dynamic of neuronal interactions and that is mostly applied for brain activity analysis.…

Neurons and Cognition · Quantitative Biology 2022-02-17 Marie-Constance Corsi , Sylvain Chevallier , Fabrizio De Vico Fallani , Florian Yger

Examining task-free functional connectivity (FC) in the human brain offers insights on how spontaneous integration and segregation of information relate to human cognition, and how this organization may be altered in different conditions,…

Functional variability in both gray matter (GM) and white matter (WM) is closely associated with human brain cognitive and developmental processes, and is commonly assessed using functional connectivity (FC). However, as a correlation-based…

Neurons and Cognition · Quantitative Biology 2025-10-09 Xinle Chang , Yang Yang , Yueran Li , Zhengcen Li , Haijin Zeng , Jingyong Su

Estimating causal interactions in the brain from functional magnetic resonance imaging (fMRI) data remains a challenging task. Multiple studies have demonstrated that all current approaches to determine direction of connectivity perform…

Neurons and Cognition · Quantitative Biology 2019-05-31 Natalia Bielczyk , Alberto Llera , Jan Buitelaar , Jeffrey Glennon , Christian Beckmann

Machine learning algorithms are designed to capture complex relationships between features. In this context, the high dimensionality of data often results in poor model performance, with the risk of overfitting. Feature selection, the…

Machine Learning · Computer Science 2023-10-18 Paolo Bonetti , Alberto Maria Metelli , Marcello Restelli