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In this paper, we consider the problem of parametric empirical Bayes estimation of an i.i.d. prior in high-dimensional Bayesian linear regression, with random design. We obtain the asymptotic distribution of the variational Empirical Bayes…

Statistics Theory · Mathematics 2026-02-25 Seunghyun Lee , Nabarun Deb

Ordinary differential equations (ODEs) are used to model dynamic systems appearing in engineering, physics, biomedical sciences and many other fields. These equations contain unknown parameters, say $\bm\theta$ of physical significance…

Statistics Theory · Mathematics 2014-11-05 Prithwish Bhaumik , Subhashis Ghosal

This paper proposes an effective treatment of hyperparameters in the Bayesian inference of a scalar field from indirect observations. Obtaining the joint posterior distribution of the field and its hyperparameters is challenging. The…

Numerical Analysis · Mathematics 2025-01-20 Nadège Polette , Olivier Le Maître , Pierre Sochala , Alexandrine Gesret

Experiments that pursue detection of signals from the Epoch of Reionization (EoR) are relying on spectral smoothness of source spectra at low frequencies. This article empirically explores the effect of foreground spectra on EoR experiments…

A conventional method to determine beam parameters is using the profile measurements and converting them into the values of twiss parameters and beam emittance at a specified position. The beam information can be used to improve transverse…

Accelerator Physics · Physics 2015-07-14 Ji-Ho Jang , Hyo Jae Jang , Dong-O Jeon

To support and guide an extensive experimental research into systems biology of signaling pathways, increasingly more mechanistic models are being developed with hopes of gaining further insight into biological processes. In order to…

Quantitative Methods · Quantitative Biology 2009-05-28 Tina Toni , Michael P. H. Stumpf

Parameter estimation is one of the most important tasks in statistics, and is key to helping people understand the distribution behind a sample of observations. Traditionally parameter estimation is done either by closed-form solutions…

Machine Learning · Computer Science 2024-03-04 Xiaoxin Yin , David S. Yin

Inferring the parameters of a stochastic model based on experimental observations is central to the scientific method. A particularly challenging setting is when the model is strongly indeterminate, i.e. when distinct sets of parameters…

Machine Learning · Statistics 2021-11-10 Pedro L. C. Rodrigues , Thomas Moreau , Gilles Louppe , Alexandre Gramfort

We extend 21CMMC, a Monte Carlo Markov Chain sampler of 3D reionisation simulations, to perform parameter estimation directly on 3D light-cones of the cosmic 21cm signal. This brings theoretical analysis closer to the tomographic 21-cm…

Cosmology and Nongalactic Astrophysics · Physics 2018-04-11 Bradley Greig , Andrei Mesinger

Ordinary differential equation models have become a standard tool for the mechanistic description of biochemical processes. If parameters are inferred from experimental data, such mechanistic models can provide accurate predictions about…

Quantitative Methods · Quantitative Biology 2018-10-12 Fabian Fröhlich , Carolin Loos , Jan Hasenauer

Direct detection of the Epoch of Reionization (EoR) via the red-shifted 21-cm line will have unprecedented implications on the study of structure formation in the infant Universe. To fulfill this promise, current and future 21-cm…

Cosmology and Nongalactic Astrophysics · Physics 2017-12-27 Abhik Ghosh , Florent Mertens , Leon V. E. Koopmans

Observation of redshifted 21-cm signals from neutral hydrogen holds the key to understanding the structure formation and its evolution during the reionization and post-reionization era. Apart from the presence of orders of magnitude larger…

Instrumentation and Methods for Astrophysics · Physics 2022-03-02 Jais Kumar , Prasun Dutta , Samir Choudhuri , Nirupam Roy

We consider the so-called unfolding problem in experimental high energy physics, where the goal is to estimate the true spectrum of elementary particles given observations distorted by measurement error due to the limited resolution of a…

Applications · Statistics 2014-02-03 Mikael Kuusela , Victor M. Panaretos

Histogram-based empirical Bayes methods developed for analyzing data for large numbers of genes, SNPs, or other biological features tend to have large biases when applied to data with a smaller number of features such as genes with…

Methodology · Statistics 2013-10-10 Marta Padilla , David R. Bickel

The redshifted 21-cm signal from the Cosmic Dawn and Epoch of Reionization carries invaluable information about the cosmology and astrophysics of the early Universe. Analyzing data from a sky-averaged 21-cm signal experiment requires…

Cosmology and Nongalactic Astrophysics · Physics 2025-06-16 Anchal Saxena , P. Daniel Meerburg , Christoph Weniger , Eloy de Lera Acedo , Will Handley

Random effects model can account for the lack of fitting a regression model and increase precision of estimating area-level means. However, in case that the synthetic mean provides accurate estimates, the prior distribution may inflate an…

Methodology · Statistics 2016-12-05 Shonosuke Sugasawa , Tatsuya Kubokawa , Kota Ogasawara

Markov Chain Monte Carlo (MCMC) techniques are now widely used for cosmological parameter estimation. Chains are generated to sample the posterior probability distribution obtained following the Bayesian approach. An important issue is how…

We study a spectral initialization method that serves a key role in recent work on estimating signals in nonconvex settings. Previous analysis of this method focuses on the phase retrieval problem and provides only performance bounds. In…

Information Theory · Computer Science 2019-07-23 Yue M. Lu , Gen Li

An outstanding question in X-ray single particle imaging experiments has been the feasibility of imaging sub 10-nm-sized biomolecules under realistic experimental conditions where very few photons are expected to be measured in a single…