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Lymphoma diagnosis, particularly distinguishing between subtypes, is critical for effective treatment but remains challenging due to the subtle morphological differences in histopathological images. This study presents a novel hybrid deep…

Image and Video Processing · Electrical Eng. & Systems 2024-10-10 Salah A. Aly , Ali Bakhiet , Mazen Balat

Nuclei segmentation is a fundamental task that is critical for various computational pathology applications including nuclei morphology analysis, cell type classification, and cancer grading. Conventional vision-based methods for nuclei…

Computer Vision and Pattern Recognition · Computer Science 2018-10-23 Faisal Mahmood , Daniel Borders , Richard Chen , Gregory N. McKay , Kevan J. Salimian , Alexander Baras , Nicholas J. Durr

Manual annotation of pathology slides for cancer diagnosis is laborious and repetitive. Therefore, much effort has been devoted to develop computer vision solutions. Our approach, (FLASH), is based on a Deep Convolutional Neural Network…

Computer Vision and Pattern Recognition · Computer Science 2020-04-21 Gabriel Tjio , Xulei Yang , Jia Mei Hong , Sum Thai Wong , Vanessa Ding , Andre Choo , Yi Su

There exists unexplained diverse variation within the predefined colon cancer stages using only features either from genomics or histopathological whole slide images as prognostic factors. Unraveling this variation will bring about improved…

Quantitative Methods · Quantitative Biology 2022-12-15 Olalekan Ogundipe , Zeyneb Kurt , Wai Lok Woo

Skin cancer is the most common cancer worldwide, with melanoma being the deadliest form. Dermoscopy is a skin imaging modality that has shown an improvement in the diagnosis of skin cancer compared to visual examination without support. We…

Image and Video Processing · Electrical Eng. & Systems 2021-01-12 Josef Steppan , Sten Hanke

Contrastive learning has gained popularity due to its robustness with good feature representation performance. However, cosine distance, the commonly used similarity metric in contrastive learning, is not well suited to represent the…

Computer Vision and Pattern Recognition · Computer Science 2023-06-27 Jing Wei Tan , Won-Ki Jeong

Cancer detection and classification from gigapixel whole slide images of stained tissue specimens has recently experienced enormous progress in computational histopathology. The limitation of available pixel-wise annotated scans shifted the…

Computer Vision and Pattern Recognition · Computer Science 2023-03-30 Mehdi Naouar , Gabriel Kalweit , Ignacio Mastroleo , Philipp Poxleitner , Marc Metzger , Joschka Boedecker , Maria Kalweit

Oral cancer incidence is rapidly increasing worldwide. The most important determinant factor in cancer survival is early diagnosis. To facilitate large scale screening, we propose a fully automated pipeline for oral cancer detection on…

Image and Video Processing · Electrical Eng. & Systems 2020-09-14 Jiahao Lu , Nataša Sladoje , Christina Runow Stark , Eva Darai Ramqvist , Jan-Michaél Hirsch , Joakim Lindblad

The task of multimodal cancer detection is to determine the locations and categories of lesions by using different imaging techniques, which is one of the key research methods for cancer diagnosis. Recently, deep learning-based object…

Image and Video Processing · Electrical Eng. & Systems 2023-12-06 Yan Tian , Zhaocheng Xu , Yujun Ma , Weiping Ding , Ruili Wang , Zhihong Gao , Guohua Cheng , Linyang He , Xuran Zhao

The density of mitotic figures within tumor tissue is known to be highly correlated with tumor proliferation and thus is an important marker in tumor grading. Recognition of mitotic figures by pathologists is known to be subject to a strong…

This paper explores the application of Human-in-the-Loop (HITL) strategies in training machine learning models in the medical domain. In this case a doctor-in-the-loop approach is proposed to leverage human expertise in dealing with large…

Computer Vision and Pattern Recognition · Computer Science 2024-04-01 David Vázquez-Lema , Eduardo Mosqueira-Rey , Elena Hernández-Pereira , Carlos Fernández-Lozano , Fernando Seara-Romera , Jorge Pombo-Otero

This study focuses on automatic skin cancer detection using a Meta-learning approach for dermoscopic images. The aim of this study is to explore the benefits of the generalization of the knowledge extracted from non-medical data in the…

Computer Vision and Pattern Recognition · Computer Science 2021-04-23 Sara I. Garcia

We have tested recently published foundation models for histopathology for image retrieval. We report macro average of F1 score for top-1 retrieval, majority of top-3 retrievals, and majority of top-5 retrievals. We perform zero-shot…

Image and Video Processing · Electrical Eng. & Systems 2024-09-13 Saghir Alfasly , Ghazal Alabtah , Sobhan Hemati , Krishna Rani Kalari , H. R. Tizhoosh

Automatic segmentation of tumor lesions is a critical initial processing step for quantitative PET/CT analysis. However, numerous tumor lesion with different shapes, sizes, and uptake intensity may be distributed in different anatomical…

Image and Video Processing · Electrical Eng. & Systems 2022-09-07 Shaonan Zhong , Junyang Mo , Zhantao Liu

The process of digitising histology slides involves multiple factors that can affect a whole slide image's (WSI) final appearance, including the staining protocol, scanner, and tissue type. This variability constitutes a domain shift and…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Manahil Raza , Saad Bashir , Talha Qaiser , Nasir Rajpoot

In recent years, deep learning has successfully been applied to automate a wide variety of tasks in diagnostic histopathology. However, fast and reliable localization of small-scale regions-of-interest (ROI) has remained a key challenge, as…

Image and Video Processing · Electrical Eng. & Systems 2022-01-06 Jon Braatz , Pranav Rajpurkar , Stephanie Zhang , Andrew Y. Ng , Jeanne Shen

One issue with computer based histopathology image analysis is that the size of the raw image is usually very large. Taking the raw image as input to the deep learning model would be computationally expensive while resizing the raw image to…

Computer Vision and Pattern Recognition · Computer Science 2019-03-01 Bolei Xu , Jingxin Liu , Xianxu Hou , Bozhi Liu , Jon Garibaldi , Ian O. Ellis , Andy Green , Linlin Shen , Guoping Qiu

Recently, deep learning has started to play an essential role in healthcare applications, including image search in digital pathology. Despite the recent progress in computer vision, significant issues remain for image searching in…

Image and Video Processing · Electrical Eng. & Systems 2023-04-19 Pooria Mazaheri , Azam Asilian Bidgoli , Shahryar Rahnamayan , H. R. Tizhoosh

Deep learning has achieved remarkable success in medical image analysis, yet its performance remains highly sensitive to the heterogeneity of clinical data. Differences in imaging hardware, staining protocols, and acquisition conditions…

Image and Video Processing · Electrical Eng. & Systems 2026-03-18 Callen MacPhee , Yiming Zhou , Koichiro Kishima , Bahram Jalali

Visual microscopic study of diseased tissue by pathologists has been the cornerstone for cancer diagnosis and prognostication for more than a century. Recently, deep learning methods have made significant advances in the analysis and…

Image and Video Processing · Electrical Eng. & Systems 2022-09-30 Puria Azadi Moghadam , Sanne Van Dalen , Karina C. Martin , Jochen Lennerz , Stephen Yip , Hossein Farahani , Ali Bashashati